Biomedical subjects
Publications and source records attributed to L Newman.
The testes of five monkeys (Macaca radiata) were examined histologically for evidence of damage, following in utero fractionated X-irradiation. Radiation-induced damage was found in the testes of animals beginning at total exposures of 170 r, when compared to controls.
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Explore the source record for details and available documents.
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We present a case of a 4-month-old female infant with a maxillary melanotic neuroectodermal tumor of infancy (MNTI) and review the pooled data from previous publications on this entity. The literature to date comprises 378 reported cases from 1918 to the present, from which data on the presence or absence of metastatic disease was available in 311, and on the presence or absence of local recurrence in 165. These pooled data suggest a local recurrence rate of 36% with metastasis occurring in 7% of cases. At present, the optimal management includes complete surgical excision with clear margins, but there are no reliable histopathological or molecular features to predict the biological behavior in individual cases.
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Broiler chicks were administered vaccines against Newcastle disease and infectious bronchitis (both Arkansas and Massachusetts strains) at 2 weeks of age as either primary or secondary vaccinations. The vaccine was administered as a spray at 2 weeks of age to chicks that had received Newcastle disease vaccine alone, bronchitis vaccine alone, both vaccines in combination, or no vaccine at day 1 in the hatchery. The Newcastle disease hemagglutination-inhibition response was significantly lower in chicks receiving Newcastle disease vaccine as a secondary vaccine at 2 weeks than in those receiving the vaccine as a primary vaccination at that age. In contrast, the bronchitis hemagglutination-inhibition response was significantly higher in chicks receiving bronchitis vaccine as a secondary vaccination at 2 weeks than in those receiving the vaccine as a primary vaccination at that age.
Many inhaled agents in the workplace can induce immunologic responses. Given the current state of clinical immunology, this article focuses on how to detect the body's response to those inhaled agents that behave as antigens. First the types of immunologic mechanisms that are activated in occupational lung disease are discussed, and the tests that reflect those states of immunologic activation. The second part of the article reviews major classes of occupational lung diseases and the immunologic tools that are available in making specific diagnoses.