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Biomedical subjects

L Nagy

Publications and source records attributed to L Nagy.

At least 181 records · Page 10Linked to original sources
PubMed1987

Examination of the iron, copper and zinc contents in the daily menu of teen-agers.

The Fe, Cu- and Zn contents of the daily menu of teen-agers were examined over two years with 124 samples taken. The samples were homogenized, subsequently dried at 104 degrees C finally incinerated at 480 degrees C. The ash was dissolved by heating with 3 N HCl. Determination of the three micro-elements was carried out by atomic absorption spectrophotometry. It was found that the daily intake of the micro-elements investigated is much below the value proposed by FAO/WHO, however, somewhat higher than the calculated Hungarian data. According to measurements, the average daily micro-element intake is 10.77 +/- 4.42 mg for iron; 1.23 +/- 0.65 mg for copper and 9.44 +/- 2.39 mg for zinc. With enumeration of iron, copper and zinc sources, dietary recommendations are given in order to increase the average values.

Adolescent↗
PubMed1986

Effects of indomethacin, prostaglandins E2 and I2 on the tone of human isolated femoral arteries.

Strips of endothelium-denuded femoral arteries from operated patients were set up for isometric recording. Indomethacin (IND, 3 mumol 1(-1] enhanced basal tension of the arteries from 0.13 +/- 0.04 to 0.86 +/- 0.12 mN (P less than 0.001; n = 16) and potentiated the contractile responses of the strips to noradrenaline (NA); EC50 for NA was 1.5 +/- 0.3 mumol 1(-1) (n = 6) in the absence, and 0.4 +/- 0.07 mumol 1(-1) (n = 6) in the presence of IND (P less than 0.01). PGI2 produced dose-related relaxation in IND-treated vessels, its IC50 being 15.0 +/- 1.3 nmol 1(-1). Low concentrations of PGE2 (0.85-8.5 nmol 1(-1] reduced whereas its higher concentrations (28-85 nmol 1(-1] increased smooth muscle tone in the presence of IND. These results indicate that human femoral arteries--unlike femoral arteries of some laboratory animals--are highly sensitive to cyclooxygenase inhibition as well as to PGI2 and PGE2.

Adult↗
PubMed1986

Biochemical background of the development of gastric mucosal damage in pylorus-ligated plus aspirin-treated rats.

Gastric mucosal damage was produced in rats after pyloric ligation by intragastric administration of 200 mg/kg aspirin diluted in 2 ml 150 mmol/l HCl. The animals in the control group received 2 ml saline solution, or submitted to pyloric ligation only. The animals were killed 4 h after the pyloric ligation, when the number and severity of gastric lesions (ulcers), and the gastric fundic mucosal level of adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), cyclic adenosine monophosphate (cAMP) and lactate, were noted and measured. The adenylate pool (ATP + ADP + AMP) and the energy charge (ATP + 0.5ADP). (ATP + ADP + AMP)-1 were calculated. It was found that: the gastric H+ output decreased significantly in the pylorus-ligated plus aspirin-treated animals; the number and severity of gastric lesions increased significantly in the pylorus-ligated aspirin-treated animals; the extent of ATP transformation into the ADP decreased significantly in the pylorus-ligated aspirin-treated animals; the extent of ATP transformation into the cAMP decreased significantly during the aspirin treatment; the values of adenylate pool and of "energy charge" remained unchanged in the different groups of animals. It is concluded that: the decreased H+ output in the pylorus-ligated plus aspirin-treated group can be obtained by the decreased extent of ATP transformation into the ADP by membrane ATPase, and the biochemical changes in the gastric mucosa indicate a decreased energy turnover.

Absorption↗
PubMed1986

Effect of indomethacin on glucose absorption and insulin release in patients with impaired glucose tolerance.

Determinations of the levels of blood glucose and of serum insulin-like activity were made in 12 patients with impaired glucose absorption treated with indomethacin 4 x 25 mg for a day. By comparing the results with untreated control patients, it was found that the peak blood level of glucose, and the serum level of insulin-like activity, could be significantly decreased by this oral administration of indomethacin. The decrease of blood level of glucose appeared 0.5 h before the decrease of insulin-like activity in these patients with impaired glucose tolerance.

Administration, Oral↗
PubMed1986

The interrelationships between the lipid peroxidation, superoxide dismutase activity, development of gastric H+ secretion and gastric mucosal damage produced by intragastric administration of aspirin in pylorus-ligated rats.

Gastric mucosal damage of pylorus-ligated rats was induced by the intragastric administration of aspirin at 200 mg/kg at the time of ligation. The animals were sacrificed at 0, 1, 2, 3, and 4 h after the treatment. The gastric lesions (ulcers) were counted and their severities were calculated, and the volume of gastric secretion and the H+ output were measured. The extent of lipid peroxidation was assessed by measuring the malondialdehyde (MDA) in the gastric mucosa, simultaneously with measurement of the activity of superoxide dismutase (SOD). It was found in these pylorus-ligated rats that: the number of visible gastric lesions was significantly higher 1 h after aspirin administration than at other times; the severity of gastric lesions increased significantly at the 3rd and 4th hour after administration of aspirin; the volume of gastric secretory responses increased gradually after administration of aspirin and to a higher extent than the H+ output; the H+ output was significantly less after aspirin administration than that after pylorus ligation only; the gastric mucosal SOD activity significantly increased 1 h after administration of aspirin, decreasing significantly and gradually thereafter; the tissue level of MDA remained unchanged 1 h after aspirin administration, decreasing significantly thereafter.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1986

Evidence of the gastric cytoprotective effects of vitamin A, atropine and cimetidine on the development of gastric mucosal damage produced by administration of indomethacin in healthy subjects.

Certain compounds such as prostaglandins, atropine, cimetidine and carotenes are able to prevent the development of gastric mucosal damage produced in experimental animals or in man by intragastric administration of necrotizing agents such as indomethacin without significantly inhibiting gastric acid secretion. The clinical background of this gastric cytoprotection and its importance for man is not yet known, although the beneficial effects of these compounds have been demonstrated in human therapy. In the present study, carried out in 66 healthy human subjects, it was found that vitamin A at a dose of 100,000 IU i.m., atropine at 0.125 mg i.m., and cimetidine at 12.5 mg i.m., which doses do not inhibit the gastric basal secretion nor the maximal secretory response to pentagastrin stimulation, each prevented the gastric microbleeding produced by the oral application of indomethacin. It is concluded that this gastric cytoprotection, characteristic of prostaglandins but extending to atropine, cimetidine and vitamin A, holds good in man as well as experimental animals. Thus the potential clinical significance of gastric cytoprotection induced by these compounds may be considerable.

Atropine↗
PubMed1985

Occupational exposure to organophosphorus insecticides and synthetic pyrethroid.

Dermal and respiratory exposure to pirimiphosmethyl, dimethoate and permethrin were determined for applicators and operators in greenhouse tomato spraying operations. Dermal exposure is several times higher than the degree of respiratory exposure. Dermal exposure in terms of different parts of the body shows significant differences. For applicators the exposure of hands, arms and legs is the greatest, and the operators are the most exposed on their hands and to a small extent on legs. This fact should be taken into account when providing the workers with suitable protective clothing. The carefully selected technology of spraying also has great significance in decreasing the degree of exposure. Because of the chronic toxicity of dimethoate, all possible methods should be taken to reduce exposure.

Agricultural Workers' Diseases↗
PubMed1985

Effect of Zaditen on serum neutrophil chemotactic activity in exercise-induced asthma.

Zaditen has a partial blocking effect in exercise-induced asthma, but the mechanism of this effect is unknown. In our study we investigated the effect of Zaditen on one of the mediators released by mast cells. We measured the serum neutrophil chemotactic activity - by using a modified Boyden chamber assay - after 2 week's treatment with Zaditen or placebo. The airway parameters (SGaw) were recorded with a wholebody plethysmograph. Our studies on 10 patients show that Zaditen has a protective effect on the release of the neutrophil chemotactic factor during an exercise challenge test. A direct effect of Zaditen on the mast cell degranulation process is postulated.

Adult↗
PubMed1985

Some aspects of the critical evaluation of peptic ulcer therapy in patients.

The disease peptic ulcer in patients does not present a uniform clinical entity. Hence, the therapeutic approaches to peptic ulcers are significantly different. Independently from the therapeutically given drugs, some common problems can be found in the methods of critical evaluation of the peptic ulcer therapy in patients. This paper deals with goals, the possible ways to evaluate critically the efficacy of peptic ulcer therapy and the problems in patients in relation to both evaluation of clinical pharmacology and as well as to everyday medical practice.

Anti-Ulcer Agents↗