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Biomedical subjects

L Naftalin

Publications and source records attributed to L Naftalin.

At least 19 recordsLinked to original sources
PubMed1994

The possible roles of hormones and enzymes in the production of the acute attack in Menière's disease.

Clinically, the earlier acute vertiginous attacks in Menière's disease and the later deafness appear to constitute a continuum. It is therefore possible that effective treatment of the cause of the acute attacks might prevent the later auditory symptoms. This paper describes biochemical events preceding the acute attacks, and then points to a common factor in the acute and chronic states. If true, this occurrence supports use of intravenous calcium gluconate to abort or cut short an acute attack. Because of the complexities of the situation, it is probable that not every Menière's disease patient will respond to this treatment and a controlled widespread trial is necessary.

Acute Disease↗
PubMed1992

Mechanoelectrical transduction, ion movement and water stasis in uromodulin.

Mechanical movement of a column of the urinary glycoprotein uromodulin modulates an applied voltage. This change is a property of the glycoprotein and its interaction with the walls of the container and is related to its capacitance. The voltage modulation is not accompanied by changes in rotationally restricted water as has been reported for hyaluronic acid. Diffusion experiments with tritiated water also support the hypothesis that uromodulin acts as a water barrier, but allows ion movement.

Electrochemistry↗
PubMed1981

Energy transduction in the cochlea.

Reasons are presented for considering that the properties of the travelling wave as described by von Békésy are inadequate by themselves to explain phenomena at the threshold of hearing as regards energetics and speed of acoustic transmission. The degree of "tuning" of the basilar membrane is also insufficient. Alternative propositions based on the physico-chemical properties and macromolecular physics of the tectorial membrane are offered. These proposals have both an experimental and theoretical basis. The final section indicates how several unresolved problems of cochlear function might be approached from this fresh standpoint.

Acoustics↗
PubMed1980

Case report of ?hormonal vertigo.

A case-history of episodic vertigo, extending over 25 years, is reported. This case was twice investigated from the neurological standpoint without a definite conclusion being reached. Eventually a hormonal-electrolyte disturbance was postulated and, to some extent, established by prolonged observation and treatment.

Adult↗
PubMed1980

Frequency analysis in the cochlea and the traveling wave of von Békésy.

Certain experimental data are difficult to reconcile with von Békésy's traveling-wave concept as operative at low energy inputs; i.e., at threshold or near-threshold of hearing. These data, ranging from energy-input values to anatomical and psychoacoustic observations, indicate the possibility of alternative or additional modes of molecular transduction. One such mode is proposed, based on experimental evidence.

Animals↗
PubMed1977

The peripheral hearing mechanism: new biophysical concepts for transduction of the acoustic signal to an electrochemical event.

A theory of peripheral function in hearing is proposed. It accounts for temporal discrimination among simultaneously received wave and pulse signals, cochlear analysis of acoustic input, and transduction of acoustic energy into biochemical energy by means of resonance and ion-shuttling involving the tectorial membrane and hair-cell complex. The postulated mechanism is such that it can accommodate the enormous range of intensity accessible to the mammalian ear. Synthesized by the theory are numerous empirical observations and experimental results reported by a broad gamut of disciplines but hitherto not unified. Additional support derives from the characteristics of an artificial "cochlea" and an electret (protein) microphone or "ion exchange microphone" with implications for enzyme conformational change.

Acoustic Stimulation↗