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L N Zimina

Publications and source records attributed to L N Zimina.

18 recordsLinked to original sources
PubMed1990

[Evaluation of the clinical significance of determining the level of plasma fibronectin in acute poisoning].

Changes in plasma fibronectin (FN) levels in acute toxic conditions have been studied in 24 patients. A significant reduction of FN concentration was found within the first days of the disease; further changes in the FN levels are related to the disease outcome and have a prognostic value. An inverse correlation was found between the FN concentration and other blood biochemical parameters (LDH, creatinine, and urea). Developed renal insufficiency in the presence of hypofibronectinemia suggests a poor prognosis of the disease.

Acute Disease↗
PubMed1989

[Treatment of open injuries in the victims of the earthquake in Armenian SSR].

The results of treatment of 36 patients injured during the earthquake in Armenia are analyzed. The patients had severe traumas: open injuries to the limbs, complicated by nephro- and hepatopathies. The periods of the limb crushing with fragments of ruined buildings varied from 3 hours to 3 days. The treatment modalities included conservative and operative detoxication (hemoperfusion, hemodiafiltration, hemofiltration, prolonged endolymphatic infusions of drugs), active surgical strategy, rehabilitation of patients. Seven amputations, 7 reamputations, and 21 necrectomies were performed in 36 patients by vital indications; no lethal outcomes were recorded. Restorative skin plasty was performed in 14 patients with 19 limb stumps, with good functional outcomes. The patients were directed to the Central Research Institute of Prosthetics to be supplied with prostheses. Only in 3 patients with the upper limb crushing the development of stable ischemic contractures could not be prevented.

Amputation Stumps↗
PubMed1988

[Drug-induced hepato- and nephropathy].

Upon clinical and pathological analyses of the evidence obtained on drug-related lethal nephropathies (51 cases) and hepatopathies (14 cases) as well as at puncture biopsies of the livers affected by chemotherapeutic agents it was determined that the commonest variants of the disturbances were tubular nephropathies, tubular-interstitial nephritis, papillary renal necrosis, symmetric cortical renal necrosis, fulminant hepatopathies with diffuse massive necrosis of hepatocytes. For biopsies, cholestatic drug-induced hepatopathies were found most frequently. As a rule, the patients received polychemotherapy with psychotropic, cardiovascular and antidiabetic drugs, nonsteroids, antibiotics, sulfanilamides, consumed contrast diagnostic media. The attention is drawn to considerable diagnostic difficulties faced in drug-induced damage to the organs which can be diminished by comparisons between clinical and morphological findings.

Adolescent↗
PubMed1985

[Pathological anatomy of the myorenal syndrome in the light of current methods of treatment].

Clinical and morphologic analysis of material from 39 patients who died from the myorenal syndrome is given. It is shown that during last 10 years the mortality rate from this syndrome is markedly reduced from 55 to 14% due to new active methods of detoxication. The main morphologic manifestations of the syndrome remain the skeletal muscles necrosis and hemoglobinuric nephrosis leading to acute renal failure. The author describes morphologic, histochemical and electron microscopic features of these lesions. It is noted also that progress in the treatment changed the whole structure of mortality, and the role of new complications, mainly septicemia, was increased. The sources of septicemia are both skin and muscles lesions and catheters and shunts used in modern methods of treatment.

Acute Kidney Injury↗
PubMed1980

[Morphological changes in the kidneys after carbon tetrachloride poisoning].

Structural alterations in the kidneys of 40 patients deceased from carbon tetrachloride (CCl4) poisoning were examined. All the patients had died with severe acute hepatic and renal failure. The authors found that it was consecutively developing hydropic and protein dystrophy of both proximal and distal tubules which accounted for acute renal failure. Changes in the glomeruli of the type of membranous glomerulopathy were also found. In the authors' opinion, the main cause of these alterations of the kidneys was presumably severe hepatic insufficiency with metabolic and immune disturbances.

Adult↗
PubMed1977

[Morphologic changes in the liver and kidney in ethylene glycol poisoning].

The liver and kidneys of 48 persons who had died of poisoning with ethyleneglycol were investigated at periods from 4 hours to 32 days following the poisoning. In 44 deceased who had died 2--32 days after the poising of acute renal and hepato-renal insufficiency there were revealed lesions characteristic of this intoxication. The structural basis of glycolic nephrosis and hepatosis was hydropic dystrophy of the nephrothelium of proximal and distal tubules and of hepatocytes of the centers of the liver lobules with outcome into colliquative necrosis through ballon dystrophy. Specific lesions of thekidney and liver may be accounted for by a high osmotic activity of ethyleneglycol and products of its metabolism; these were captured by the renal and hepatic epithelium in the process of reabsorption and pinocytosis increasing drastically the osmotic concentration of the intracellular liquid, which was accompanied by rapid inflow of water into the cell and its hydropic dystrophy.

Acute Kidney Injury↗
PubMed1976

[Acute renal insufficiency in exogenous poisoning (problems of classification and pathogenesis)].

Acute renal insufficiency (ARI) -- one of the most frequent manifestations of many exogenous intoxications. On the ground of a morphological investigation of 625 kidneys in poisoning with various poisons, the authors have come to the conclusion that the acute nephrotic syndrome is the basis of ARI in a "toxic" kidney". A morphological classification of the nephrotic syndrome is given: necrotic nephrosis hydropic nephrosis (glycolic nephrosis), cortical necrosis of the kidney, excretory nephrosis, acute lipid nephrosis. Morphological characteristics of the nephrotic syndrome forms referred to above are presented. Lesions of the kidney in exogenous intoxications are caused first of all by the direct toxic action of a poison. Toxic shock is an important factor in the development of ARI.

Acetates↗
PubMed1975

[Morphological changes in the kidney in acetic acid poisoning].

The kidneys of 118 patients who had perished because of vinegar acid poisoning were studied morphologically in periods from 2 hours to 26 days. Comparisons of morphological findings and clinical patterns and different methods of treatment of this kind of intoxication were made. Lesions of the kidneys in vinegar acid poisoning were similar to those in acute hemoglobinuric nephrosis. A characteristic morphological feature of acute renal insufficiency was ruptures of distal tubules. Some peculiar features of the morphology of the kidneys in acute renal insufficiency associated with treatment methods (stimulation of osmotic diuresis, hemodialysis and peritoneal dialyses) were revealed. It was established that early intensive complex therapy changed essentially the morphological picture of acute hemoglobinuric nephrosis and could prevent irreversible lesions--ruptures of distal tubules.

Acetates↗
PubMed1973

[Breast sarcoma].

Explore the source record for details and available documents.

Adenofibroma↗
PubMedDate not supplied

[The clinico-morphological toxicodynamics of organophosphate insecticide poisonings].

The article deals with investigation of dynamics of clinical morphological pattern in acute poisoning with organophosphorous insecticides. For this purpose all specific and non-specific effects of this chemical disease are classified according to the moment of their occurrence after poison exposure. Morphological equivalent of specific clinical manifestations at different stages of thanatogenesis of this poisoning was determined. It was shown that intensity of pathological process or specific density of toxic effects per time-unit is a very important criterium for assessment of severity and prognosis of poisoning.

Acute Disease↗