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L N Fontalin

Publications and source records attributed to L N Fontalin.

80 records · Page 5Linked to original sources
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[Nonspecific non-reactivity in mice induced by joint administration of Newcastle disease virus and cyclophosphamide].

The immunomodulating effect of Newcastle disease virus (NDV) was investigated in vitro and in vivo in mice. NDV was shown to induce a mitogenic effect in splenocytes in vitro. Combined injections of NDV and CP resulted in nonspecific suppression of immunoreactivity in mice. The antibody production and development of delayed type hypersensitivity to sheep erythrocytes were markedly reduced. Injections of NDV alone slightly increased the reactions. The NDV + CP injections led also to a reduction of immune response to thymus-independent antigen, LPS. Thus, the combined injections of NDV and CP led to nonspecific suppression of T and B cell immunity in mice. The mechanisms of this form of anergy require further study.

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[Characteristics of immune reactions to the influenza virus in mice with a slow influenzal infection].

It had previously been shown that intrauterine infection of mice with influenza virus resulted in growth retardation and significant immunosuppression to various nonspecific agents and influenza virus. The present study demonstrated that such mice also had lower production of specific antibody and reduced capacity to form the delayed hypersensitivity to influenza virus. Despite the lack of specific immune response, such mice had high levels of response to influenza virus in adoptive transfer. The reasons for which lymphocytes of mice with slow influenza infection fail to manifest their immunological potentials in situ require further study.

Animals↗