Search PubMed⌕ Search

Biomedical subjects

L Munan

Publications and source records attributed to L Munan.

At least 37 records · Page 2Linked to original sources
PubMed1978

An epidemiologic study of breast cancer.

A case-control study has been conducted in four areas of Canada in which 400 cases of breast cancer matched by age and marital status with neighborhood controls were administered medical and dietary questionnaires. The study is suggestive of an increased risk of breast cancer in post-menopausal women with younger age at menarche and an increased risk with delay of age at natural menopause. No protective effect of early age at first pregnancy was demonstrated in either pre- or post-menopausal women. An increased frequency of pregnancies of four months duration or less was found in cases compared to controls and a greater frequency in pre-menopausal cases compared to controls of a history of irregular menstrual periods. In pre-menopausal women no association has been found between increased height and weight as risk factors for breast cancer. For post-menopausal women, however, a weak association with increased height has been found, while a strong association with increased weight both at the time of menopause and the 12 months preceding diagnosis has ben confirmed.

Adolescent↗
PubMed1977

Enzymatic activity patterns in probability population samples. Serum lactate dehydrogenase.

Sex- and age-specific serum lactate dehydrogenase values provided by a natural population of 2,378 individuals selected by a multistage area cluster probability sampling scheme are given. The activity of this enzyme has definite sex and age associations over the age range studied (larger than or equal to 10 years). In both sexes, it is characterized by elevations in preadolescents, by a sharp decrease in adolescent groups, and by a gradual increase in adult and senescent groups, which, however, does not bring it back to earlier levels. Males have higher mean serum lactate dehydrogenase activities than females in most age groups until about 50 years of age. Unusually high activities have been found in this study, compared with those found in two other widely separated areas in North America using the same assay procedures.

Adolescent↗
PubMed1977

Haematologic profile of natural populations: red cell parameters.

Age-sex specific reference values and frequency distribution of erythrocyte parameters were derived from a representative sample of a natural population consisting of 1094 men and 1284 women between 10 and 96 years of age. Some differences have been found between previously reported reference values and those presented here, the importance of which lies not so much in their magnitude as in the fact that the latter are based upon a probability sample of a natural population unselected as to disease and are presented as percentile distributions by age and sex rather than as the more frequently used normal distribution. These results are intended for use as reference data both for clinical and for population estimates of haematological parameters.

Adolescent↗
PubMed1977

Serum urate levels between ages 10 and 14: changes in sex trends.

Urate levels were assayed in sera of 292 subjects between 10 and 14 years of age identified through a probability sample of a natural population. The sex trends in serum urate concentrations characteristic of childhood were seen to continue into early adolescence, with girls maintaining slightly higher means. Between 10 and 14 years there was first an overlap of male and female values followed by a reversal of trends, with much higher means in boys. Serum urate concentrations peaked in girls at age 11 and gradually stabilized at lower levels. Boys, on the other hand, showed little age variation in serum urate at 10 and 11 years but by age 12 showed sharp upward trends which continued throughout adolescence. Since age and body weight are known to be important covariates of serum urate, boys were matched to girls of the same age and body weight. Significant sex differences in urate levels persisted (after matching) only for 14-year-old adolescents and thus at this age could not be ascribed to weight differentials. The study highlights a peripubertal phenomenon whose mechanism might be endocrine related.

Adolescent↗
PubMed1976

Population serum urate levels and their correlates. The Sherbrooke regional study.

A natural population has been studied for its serum urate levels and for host factors associated with these levels. Householdhood, ethnicity, drug and alcohol use were found to be negligible behavioral attributes with respect to population serum urate concentrations. Of interest among significant correlates of serum urate are smoking behavior, serum protein, creatinine, calcium and monocyte count. Predominant statistically significant host factors, however, are sex, body weight and age, body weight being linearly related in both sexes and age in females only.

Adult↗
PubMed1976

Use of values for calcium and protein in serum, and of a derived index obtained from a probability population sample.

We measured serum protein and calcium concentrations in 2340 individuals between 10 and 96 years of age from 900 families chosen by probability methods to give a representative population. These values were used to calculate an index, based on a regression analysis of serum protein on calcium, which was then treated as a new variable. Age-sex specific reference values and frequency distributions are presented for this index as well as for protein and calcium calculated by both parametric and nonparametric methods.

Adolescent↗
PubMed1975

Do the right children have necropsies?. Analysis of selected determinants.

An analysis of the frequency of post-mortem examinations was conducted in the paediatric age group. Among the factors found to influence necropsy rates were (i) age at death, the frequency of necropsy decreasing with age; (ii) cause of death, necropsy frequency varying with major diagnostic groups; (iii) investigation conducted before death, necropsy frequency decreasing when the clinical picture was ill-defined; and (iv) place of death, necropsy being less frequent when death occurred outside hospital. These findings imply (a) that necropsy practices may be governed by habit and convenience as well as by desire to complete the clinical picture, and (b) that more equitable balances in such practices should be sought if there is to be improvement in the quality of mortality data.

Age Factors↗