Biomedical subjects

L Moore

Publications and source records attributed to L Moore.

274 records · Page 16Linked to original sources

PubMedDate not supplied

Investigation of rocking as a postoperative intervention to promote gastrointestinal motility.

Debilitating gas pain is a common sequel for patients who have undergone abdominal surgery. Resulting from impaired motility induced by the mechanical and psychological stresses of surgery, as well as the effects of anaesthetic and analgesic agents, accumulated gas in the bowel often leads to longer and more unpleasant hospital stays. In this article, the authors describe ongoing research aimed at mediating gas effects in women post-hysterectomy. Using rocking as a moderator of the surgical stress response, the study hypothesizes a more rapid resumption of GI motility with decreased gaseous distention and associated pain, and less emotional distress for patients who follow a regimen of rocking in addition to ambulation. A sample of 34 patients is being studied, and data are being collected during a preadmission process and 5 postoperative days.

Adolescent↗

PubMedDate not supplied

PTCA, thrombolysis or atherectomy: rational treatment of recently occluded saphenous vein grafts.

Recently occluded saphenous vein grafts (SVG) contain abundant thrombus. Distal embolization and myocardial infarction often occur when recanalization of such SVG is attempted. In 80 patients with occluded SVG, we employed transcatheter devices to lyse, compress or extract thrombus. Primary treatment for these SVG was performed in the following manner; PTCA 29, intragraft urokinase 12, TEC atherectomy 39. Following urokinase or atherectomy, adjunctive PTCA was performed to diminish the residual stenosis. All patients had class III or IV angina. Clinically, SVG occlusions were 3 days to 3 months old. TIMI flow was grade 0, and occlusion length was greater than 6 cm for all SVG. Each strategy resulted in a similar procedure success rate. However, when used as a primary treatment, TEC may be associated with lower rates of distal embolization and myocardial infarction.

Angioplasty, Balloon, Coronary↗

PubMedDate not supplied

Hepatocellular carcinoma following neonatal hepatitis.

Hepatocellular carcinoma is an uncommon malignancy in young children associated with a variety of congenital and acquired conditions. It has been generally held that idiopathic neonatal hepatitis is not an antecedent of hepatocellular neoplasia in childhood. We report a 28-month-old girl in whom a diagnosis of neonatal giant cell hepatitis was confirmed by liver biopsy at 4 months of age who was followed up with serial liver biopsies. Hepatitis B and C virus infection and metabolic abnormalities had been excluded by appropriate testing. There was no history of parenteral nutrition. The morphologic criteria for a diagnosis of cirrhosis were satisfied in a liver biopsy undertaken at 23 months of age. At 28 months a laparotomy was performed because of continuing jaundice and the development of an abdominal mass. Biopsy of the mass revealed a hepatocellular carcinoma. Ploidy studies showed an aneuploid tumor and a hyperdiploid karyotype was confirmed by chromosomal analysis. This case demonstrates by sequential biopsy the progression from neonatal hepatitis to cirrhosis and hepatocellular carcinoma in a young child.

Biopsy, Needle↗

PubMedDate not supplied

Skeletal abnormalities in Meckel syndrome.

Meckel syndrome is an autosomal recessive condition with a wide phenotypic variation. The most consistent features are cystic kidneys and intrahepatic bile duct anomalies, frequently accompanied by central nervous system (CNS) malformations and polydactyly. Approximately one sixth of all cases also show skeletal anomalies. We present two cases, siblings born to a consanguineous couple, in whom there was a striking curvature and shortening of the long bones in addition to cystic kidneys, CNS abnormalities, and polydactyly. Histological examination of the long bones in the second affected sibling showed mid-diaphysial ectopic cartilaginous growth plates differentiating the long bone changes from other skeletal dysplasias with similar radiological features.

Bile Ducts, Intrahepatic↗