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Biomedical subjects

L Montanari

Publications and source records attributed to L Montanari.

At least 73 records · Page 4Linked to original sources
PubMed1985

Antimycotic 2-alkyldithio, 2-aralkyldithio, 2-aryldithiobenzamides.

Some 2-alkyldithio, 2-aralkyldithio, 2-aryldithio benzoic acids, their methyl esters and N-monosubstituted amides were prepared and tested in vitro against Candida albicans and Trichophyton mentagrophytes. Some N-monosubstituted amides displayed activities similar to those of clotrimazole and pyrrolnitrin. Against Candida albicans, N-monosubstituted amides exhibited a generally higher activity than the corresponding N-monosubstituted amides of 2,2'-dicarboxydiphenyldisulfide.

Amides↗
PubMed1984

[Derivatives of 2-thiocyanobenzoic acid with antifungal activity].

A series of amides, esters and thioesters of 2-thiocyanobenzoic acid were synthesised and tested for antifungal activity in vitro and in vivo against various strains of fungus pathological to plants. The phytotoxicity against representative plants was studied in parallel. The substances were prepared by condensation of suitable mercaptobenzamides with cyanogen bromide or of 2-thiocyanobenzoyl chloride with amines, alcohols or mercaptans. This research showed in vitro antifungal activity of some N-monosubstituted amides and in vivo activity of some N-monosubstituted and N,N-disubstituted amides of 2-thiocyanobenzoic acid which have the same protective activity towards P. viticola as Zineb.

Animals↗
PubMed1983

[Release of prostaglandins by spleen cells in the mouse after incubation with thymosin].

The effects of i.p. administration in mice of a rabbit antiserum specific for thymic epithelial cells on T-dependent cellular immune response has been studied. As measure of T-dependent cellular immune response were taken: 1) a delayed type hypersensitivity test based on the swelling of footpad following SRBC injection in immunized mice; 2) a graft-versus-host assay valuated by splenomegaly induced in newborn mice after donors mice spleen cells i.p. injection. Both assays showed a significant reduction of cellular T-dependent immune response. The cinetic of this effect is in accord with ultrastructural changes in mice thymus, following the same treatment, previously observed.

Animals↗
PubMed1983

[Anticryptogamic activity of some aryl esters of N-benzyldithiocarbamic acid].

Some aryl esters of N-benzyldithiocarbamic acid, characterized by the presence on the S-aryl group of hydrophilic or potentially hydrophilic groups were studied for anticryptogamic activity in vitro and in vivo. The substances were prepared by condensation of benzylisothiocyanate with suitable benzenethiols. The results showed the anticryptogamic activity of acylation derivatives of N-monosubstituted thiosalicylamides with the acyl of N-benzylthiocarbamic acid.

Animals↗
PubMed1983

[Aryl esters of N-benzyldithiocarbamic acid with antimycotic activity].

Some aryl esters of N-benzyldithiocarbamic acid [substances (I leads to XVI)], in which S aryl substituents were hydrophylic or potentially hydrophylic groups, were tested for in vitro antifungal activity against the following strains: Candida albicans, Saccharomyces cerevisiae and Trichophyton mentagrophytes. The substances were prepared by condensation of benzylisothiocyanate with suitable benzenethiols. The results, given in Table I, show the marked activity as antifungal agents of the N-benzyldithiocarbamic acid aryl esters studied; the antifungal activity, connected with the N-benzyldithiocarbamic group, is only slightly influenced by the nature of the substituents.

Antifungal Agents↗
PubMed1982

[Benzenedithiol esters with antimycotic activity].

Some diesters of benzen-1,2-dithiol wit aliphatic and aromatic carboxylic acids were prepared and tested for in vitro antifungal activity. The diacetate and dipropionate of benzen-1,3- and 1,4-dithiol were used as comparison compounds. The substances (Table I; substances I leads to X) were obtained by condensation of benzenedithiols with suitable acylating agents. The fungistatic activity of the products was tested in vitro against the following fungal strains: Candida albicans, Candida tropicalis, Saccharomyces cerevisiae and Trichophyton mentagrophytes. The results show that the diester of benzen-1,2-dithiols with alkanoic acids (Table I) have marked antimycotic activity, much greater than that of clotrimazol. The diaroyl esters of benzen-1,2-dithiol and the diesters of benzen-1,3- and 1,4-dithiols are inactive or only slightly active.

Antifungal Agents↗
PubMed1982

A comparison of hysterosalpingography and laparoscopy in the investigation of infertility.

From 1974-1980, 85 patients were investigated with both hysterosalpingography (HSG) and laparoscopy. Discordant diagnosis of adhesions made the largest group of disagreements. The causes of such and other discrepancies are discussed. The Authors conclude that laparoscopy is necessary to establish a conclusive assessment of the tubal factor and must be performed before HSG. The radiologic investigation still has its place to demonstrate lesions of endosalpinx before microsurgery.

Female↗
PubMed1982

[Acaricidal, chemosterilant and insecticidal activity of triazine derivatives].

A large number of 1-aryl-3,3-dialkyl triazenes and 1,2-diphenyl triazenes variously substituted in the 3 position with OH and alkyl groups were prepared and studied for acaricide activity against Panonychus ulmi and chemosterilizing and insecticidal activity against Musca domestica. The results highlighted the marked chemosterilizing activity of 1-(2-methoxyphenyl)-3,3-di-n-propyltriazene and the interesting acaricidal activity of 1-(4-benzoylphenyl)-3,3-dimethyltriazene. The examination of such a large number of compounds for insecticidal activity allowed interesting conclusions to be drawn regarding structure/activity relationships.

Acari↗
PubMed1982

[Antifungal activity of diesters of 2-mercaptobenzene methanethiol].

Some diesters of 2-mercaptobenzenmethanthiol and of 2-(2-nitrophenyl)-1,3-benzodithiyne were prepared and tested for in vitro antifungal activity. The substances [Table I: substances (I leads to VIII)] were obtained by condensation of 2-mercaptobenzenmethanthiol with suitable reagents. The antifungal activity of the products was tested in vitro against the following strains: Candida albicans, Saccharomyces cerevisiae and Trichophyton mentagrophytes. It was found that antimycotic activity is shown by only some of the diesters of 2-mercaptobenzenmethanthiol with acyl alkylthiocarbamic groups (Table I). The diesters with aliphatic, aromatic, alkylcarbamic groups and the 2-(2-nitrophenyl)-1,3-benzodithiyne are inactive or only slightly active.

Antifungal Agents↗
PubMed1981

[Antifungal activity of 3,3'-diindolyl-2,2'-tetrasulfide].

The compound 3,3'-diindolyl-2,2'-tetrasulfide was studied for in vitro and in vivo fungistatic activity against various fungi causing human and plant diseases. The compound showed marked activity in vitro especially against dermatophytes and in the agrarian field against Botrytis cinerea. When the low phytotoxicity of the compound is taken into account, it is concluded that the compound has considerable potential as an anticryptogam.

Animals↗