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L Montalbetti

Publications and source records attributed to L Montalbetti.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Stage classification of chronic lymphatic leukemia. A retrospective analysis of 263 cases].

We have analyzed 263 consecutive patients with chronic-lymphocytic leukemia. They all have been studied according to five different staging systems respectively proposed by Rai (1975), Binet (1977), Binet again (1981), Baccarini (1982) and Rozman (1984). All these procedures proved to be effective, because they divided our cases in groups with significant differences in survival time. The paper displays features and usefulness of each staging system.

Adult↗
PubMed1990

[Lymphoma of the prostate: case reports and subject review].

Malignant lymphomas involving the prostate are rare whether as primary lymphoma or as secondary to generalized disease. Middle age, histotype prevalently non Hodgkin, intermediate and high grade of malignancy, symptoms of bladder outflow obstruction, diagnosis generally made after histological examination, severe prognosis are the most important features that result from literature review. The evaluation of therapeutic treatments is difficult as most reports do not include a sufficient number of cases. The Authors presenting two cases of lymphoma of the prostate point out the usefulness of radiotherapy since the prostate is usually a bulky seat of disease and suggest the combination with multiple drug chemotherapy for intermediate and high grade of malignancy and in advanced stages. The authors suggest that prognosis depends on histotype rather than on prostatic involvement of disease.

Adult↗
PubMed1987

[Malignant histiocytosis. Clinical contribution and review of the subject].

Malignant histiocytosis (MH) is a rare and severe disease caused by malignant histiocyte degeneration in the sinuses of the reticuloendothelial system. The clinical picture presents fever, wasting, enlargement of the liver and spleen and lymphoadenopathy. Diagnosis is based on histological criteria and it may prove very difficult to differentiate between MH and malignant lymphomas, acute monocytic leukemia and the histiocytoses considered benign. The main features of the disease are described with comments on two personally experienced clinical cases. Emphasis is placed on the leukaemic aspect, the involvement of the CNS, the association, in one case, with sarcoidosis and the poor prognosis.

Adult↗
PubMed1983

[Hypercalcemic syndrome in malignant lymphomas. Review of the literature and clinical contribution].

The appearance of hypercalcemic syndrome during the course of lymphoma is not only an unusual event, but it puts a very difficult diagnostic and therapeutic question too. There are three aetiologic moments: the diffuse osseus metastases, the paraneoplastic syndrome and concomitant primitive hyperparathyroidism. The pathogenesis of these questions has lately stimulated a new kind of research, even if there are still a lot of unknown points. The Authors suggest, as their own contribution, the revision of the literature on this subject and they also suggest an acute hypercalcemic syndrome case brought about a primitive hyperparathyroidism in a patient suffering from Hodgkin's lymphoma.

Adult↗
PubMedDate not supplied

Bone marrow biopsy for the staging of non-Hodgkin's lymphoma: bilateral or unilateral trephine biopsy?

AIM: The occurrence of unilateral involvement in bilateral bone marrow trephine biopsies in non-Hodgkin's lymphomas (NHL) at disease onset (10-20% of cases) has been reported since the early 70s. Therefore, although these studies were based on small series, the use of bilateral bone marrow biopsies has become the rule. However, the clinical value of this procedure has never been clearly established. The aim of the present study was to ascertain the true value of bilateral bone marrow biopsy in the staging of NHL. STUDY DESIGN: We examined 368 cases of NHL (A-H according to the Working Formulation) (WF), without leukemic involvement of the peripheral blood, in order to evaluate: 1) the incidence of unilateral bone marrow involvement; 2) the percentage of patients who, as a result of unilateral bone marrow involvement, changed from stages I-II to stage IV; 3) assessment of response to therapy for patients with both bilateral or unilateral bone marrow involvement. RESULTS: In the A-C NHL groups of WF there was a unilateral bone marrow involvement of 8.8%. Overall, bone marrow involvement induced a change from clinical stages I-II to stage IV in 5.6% of cases, a figure which would correspond to a false negative rate of 2.8%, if unilateral bone marrow biopsy was performed. In the D-F and G, H groups of WF, unilateral involvement was 10.1% and 8.5% respectively; the change in stage from I-II to IV by unilateral bone marrow involvement respectively amounted to 1.4% and 2.8%, which correspond to respective false negative rates of 0.7% and 1.4%. CONCLUSIONS: On the basis of these results and of the present therapeutic strategies, we propose: bilateral bone marrow biopsy for clinical stages I-II of all NHL; no bone marrow biopsy at disease onset for clinical stages III and IV of A to H histologic subtypes of the WF; unilateral bone marrow biopsy (A-C subtypes of the WF) or bilateral (D-H of the WF), after the regression of extramedullary localizations.

Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

[Primary lymphoma of the kidney. Description of a case and brief review of the literature].

Stage IV disseminated non-Hodgkin lymphomas show kidney involvement with frequency; on the contrary, primary kidney lymphoma, as the sole presenting feature, is a very rare disease. Non-Hodgkin histological pattern, atypical symptoms, marked discrepancy between parenchymal involvement and impairment of renal function are the main features of this tumor. A case-report of a primary kidney non-Hodgkin lymphoma will be described; a short review of literature on this subject will be discussed.

Aged↗
PubMedDate not supplied

Electronic pupillometry for investigating pupil reactivity to different exteroceptive stimuli: applications and limits.

Iris neuromuscular junction represents a site of reciprocal interactions of sympathetic and parasympathetic innervation and can be considered a useful tool to investigate both systems in physiological and pathological conditions. In this study 35 healthy subjects of different ages were examined by an infrared TV pupillometer to assess darkness and light adaptation, as well as pupillary response to light and to exteroceptive stimulation (RIII reflex). A progressive impairment of pupil adaptability to light stimuli with aging was also observed, while a significant correlation was found between the intensity of electrical stimulation of the sural nerve and the percent increase in pupil diameter. The evaluation of pupil responsiveness is considered for its possible applications in various neurological disorders.

Adaptation, Physiological↗
PubMedDate not supplied

A cooperative study of epirubicin with cyclophosphamide, vincristine and prednisone (CEOP) in non-Hodgkin's lymphoma.

BACKGROUND: The purpose of our cooperative trial was to investigate whether epirubicin (EPI) at 90 mg/m2 in a CHOP-like combination (called CEOP) could increase complete response (CR) and survival rates in non-Hodgkin lymphoma (NHL) patients while maintaining a tolerable degree of toxicity. METHODS: Between September 1986 and July 1992, 218 patients from 12 Centers in Lombardy entered this study. The inclusion criteria were: a histological diagnosis of intermediate or diffuse large cell (DLC) NHL and no previous radio-chemotherapy. The patients in stages IA and IIA (both intermediate and DLC) received four CEOP courses followed by local/regional radiotherapy; those with intermediate NHL in stages IB, IIB, III A and B and IV A and B received six CEOP courses and, if they achieved CR, three further courses as consolidation. RESULTS: Among the 160 evaluable patients, CR was observed in 90% of the subjects with DLC-NHL (stages IA and IIA) and in 59% of those with intermediate-grade NHL (all clinical stages). If the clinical stages are considered separately, the CR rates were 92% for stages IA, IIA and 53% for stages IB, IIB, III A and B, IV A and B. Relapses occurred in 20% of the patients treated with four CEOP courses plus radiotherapy and in 31% of those who received nine CEOP courses because of the advanced stage of their disease. As of May 1994, the median follow-up was 42 months. If all of the patients are considered together, the 7-year overall survival (OS) probability was 64% and the 7-year disease-free survival (DFS) probability 67%. In comparison with stages III/IV, the patients in stages I-II had better DFS (7-year chance 77% vs 56%, p < 0.03). Hematological toxicity was acceptable, and a delay in the administration of CEOP chemotherapy was required in only three patients. No life-threatening infections were recorded. CONCLUSIONS: Our cooperative study of the use of the CEOP combination in NHL patients shows that response rates and the length of DFS are equal to the best results obtained with CHOP and more intensive programs, although further confirmation must be provided by means of a longer follow-up and a more careful analysis of prognostic factors according to the recently proposed international index. In our experience, an EPI dose of 90 mg/m2 has negligible toxicity (particularly on bone marrow), even in elderly patients. These findings are interesting since it is well known that myelotoxicity is the principal limiting factor for the majority of anthracycline-containing regimens used in the treatment of potentially curable NHL.

Adult↗
PubMedDate not supplied

Melatonin and cortisol circadian secretion during ethanol withdrawal in chronic alcoholics.

Changes in central neurotransmission and in hypothalamo-pituitary function occur in both ethanol (ETOH) intake and withdrawal. Melatonin (MLT) secretion is regulated by the noradrenergic system, which is activated upon ETOH withdrawal. Experimental evidence exist that pineal gland may have a role in ETOH intake and preference in rats. Twenty-four hour urinary excretion of MLT was found to be increased during ETOH intake in chronic alcoholics. In this study we have determined 24h plasma levels of MLT and cortisol in 8 chronic alcoholic males hospitalized for a detoxication program and in 8 healthy controls. The study was performed just after admission, on the first day of ETOH withdrawal and after 14 days of controlled abstinence. Circadian periodicity has been evaluated by the cosinor method. The initial determinations corresponded to the acute withdrawal phase. Twenty-four hour plasma MLT mean levels on acute withdrawal were higher than after 14 days abstinence and than those found in controls. Large interindividual differences prevented the detection of statistical significance. The cosinor analysis disclosed the loss of circadian periodicity in the acute withdrawal. Significant 24h periodicity was restored after 14 days abstinence. Cortisol levels were significantly higher than those found on day 14 and in healthy controls. Twenty-four hour periodicity was maintained in both alcoholics series. A delay in cortisol acrophase occurred in acute withdrawal. The effects of Corticotropin Releasing Hormone infusion on cortisol secretion were significantly enhanced in the acute withdrawal phase in comparison with those occurring when patients were retested and with healthy controls.

Adult↗