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Biomedical subjects

L Molle

Publications and source records attributed to L Molle.

At least 19 recordsLinked to original sources
PubMed1987

Selenium status in relation to clinical variables and corticosteroid treatment in rheumatoid arthritis.

Plasma selenium levels, erythrocyte selenium levels and activity of the selenoenzyme glutathione peroxidase in erythrocytes were determined in patients with rheumatoid arthritis (RA) and acute inflammatory arthritis. Results were compared with those from age and sex matched controls. These variables were not statistically different from controls in patients with inflammatory arthritis and in patients with RA not treated with corticosteroids. No correlation was found in RA between plasma selenium biological variables of inflammation and most clinical indices of disease severity. Therefore, acute or chronic inflammation was not the main factor that accounted for low plasma selenium levels in RA. Corticosteroid treatment, particularly at high doses (20-60 mg prednisolone/day), was significantly related to the depressed plasma selenium levels of some patients with RA. The mechanisms underlying this modification remain poorly understood.

Acute Disease↗
PubMed1985

Selenium deficiency.

Selenium is undoubtedly an essential trace element: its involvement in GPx structure, the presence of deleterious effects of selenium deficiency in animals, and the recognition of deficiency states in man attest to its importance. However, if the consequences of selenium deficiency in man are now widely recognized, the mechanisms underlying these conditions are poorly understood. The definition of the exact role of selenium in human homeostasis has been hampered by the lack of a sensitive parameter, usable in routine investigation, to assess selenium status. Measurements of plasma and urinary levels, although useful in clinical practice, are inadequate indicators. The only true evidence of selenium deficiency lies in a positive response to selenium therapy. Deficiency states have been demonstrated for inhabitants of regions where selenium supply is limited, in protein-energy malnutrition, and in patients maintained on total parenteral nutrition without selenium supplementation. The benefit of selenium supplementation, together with other antioxidant drugs, in non-deficient subjects is still a matter of debate; its protective effect in neoplastic, cardiovascular and neurological degenerative diseases is not yet proven.

Animals↗
PubMed1978

Binding study of benzamides to serum albumins by fluorescence probe technique.

The interaction between human and bovine serum albumins (HSA and BSA) were studied with two derivatives of benzamide, metoclopramide (Primpéran) and sultopride (Barnétil). It was possible to evaluate association constants (K ass.) characterising this interaction by fluorescence probe technique inspite of the very low binding tendency, which can be correlated to pharmacokinetic properties of these drugs.

Animals↗
PubMed1975

[Drug abuse].

Explore the source record for details and available documents.

Drug Therapy↗
PubMedDate not supplied

Useful sample handlings for reversed phase high performance liquid chromatography in emergency toxicology.

Some physicochemical treatments of biological samples, before being injected into a liquid chromatograph, are discussed. The advantages of dilution, liquid and solid extraction are compared referring mainly to unpublished results. Assays of antiepileptic drugs, caffeine, theophylline, tricyclic antidepressants, valproic acid, and meprobamate are used to demonstrate the importance of sample handlings in toxicological analyses in which reversed phase high performance liquid chromatographies are applied.

Anticonvulsants↗