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Biomedical subjects

L Molinengo

Publications and source records attributed to L Molinengo.

70 records · Page 4Linked to original sources
PubMedDate not supplied

Effect of diisopropylfluorophosphate and atropine or mecamylamine on acetylcholine levels in the central nervous system of the rat.

The effect on acetylcholine levels caused by diisopropylfluorophosphate, either alone or in combination with atropine or mecamylamine, has been studied in the olfactory brain, medulla pons and cortex of the rat. At sublethal doses (0.25 and 0.5 mg/kg), diisopropylfluorophosphate reduced the acetylcholine levels. This effect was completely antagonized by atropine in the medulla pons and by mecamylamine in the medulla pons, olfactory brain and partly in the cortex. These observations suggest that the reduction of acetylcholine levels at low doses of diisopropylfluorophosphate is mediated by a muscarinic system in the medulla pons and by a nicotinic system in the medulla pons, the olfactory brain and also, in part, in the cortex.

Acetylcholine↗
PubMedDate not supplied

Action of diisopropylfluorophosphate and of diacetylmonoxime on acetylcholine levels and on cholinesterase activity in the central nervous system.

The modification of the acetylcholinesterase (AChE) activity and of the acetylcholine (ACh) levels caused by diisopropylfluorophosphate (DFP) alone and in association with 300 mg/kg of diacetylmonoxime (DAM) have been studied in the olfactory brain, in the cortex and in the medulla-pons of the rat. DFP caused a reduction of the levels of ACh at 0.25 and 0.5 mg/kg. An increase of the levels of ACh was observed at 4.0 mg/kg of DFP only in the olfactory brain and in the cortex. A dose-dependent reduction of the AChE activity was observed after DFP. DAM reactivated the AChE activity to the levels of the controls after 0.25 and 0.5 mg/kg of DFP. In this experimental situation, the ACh levels returned to the control levels after 0.25 mg/kg of DFP and, in the medulla-pons, also after 0.5 mg/kg of DFP. DAM caused a partial recovery of the AChE activity but no modification of the ACh levels at 1.0, 2.0 and 4.0 mg/kg of DFP.

Acetylcholine↗