Search PubMed⌕ Search

Biomedical subjects

L Miller

Publications and source records attributed to L Miller.

At least 451 records · Page 25Linked to original sources
PubMed1976

Theatre and community: 'the Tent of Joseph'.

The rationale of community theatre is discussed and its mental health and social goals set forth; these are the mobilisation of creativity through the construction of an original community drama and, impelled by this and its performance, activity for community organisation. An original project in Israel and its first stages of implementation are reported and analysed.

Adolescent↗
PubMed1975

The metabolism of labeled parathyroid hormone. V. Collected biological studies.

Biologically active 125I-labeled parathyroid hormone (125I-PTH) was used in a series of studies in dogs and chickens designed to confirm and augment earlier studies in rats. As in rats, a three exponential equation was required to describe disappearance of 125I-PTH from the blood in the dog. The first two "half-lives" (1.8 and 7 min) accounted for the bulk of the dose. Also as in rats, deposition of apparently intact hormone took place rapidly in kidney, liver and bone in both the dog and the chicken. Degradation occurred very rapidly in all three target organs. Three labeled hormones of different biological activities were compared in the rat. Inactive, oxidized hormone was rejected by the liver but showed markedly increased deposition in kidney and the higher the purity of the hormone the higher was its uptake by liver. Exploration of a wide range of dosages revealed few effects on distribution (smaller deposition in liver and kidney at highest dosages, 65 mug/rat). Fresh sera did not degrade hormone rapidly or extensively. There was no deposition of hormone in intestinal mucosa, marrow, and red cells. Nephrectomy increased deposition in liver and bone. Finally, the perfused liver was capable of extensive degradation of the hormone.

Animals↗
PubMed1975

Compounding of discriminative stimuli correlated with chained and multiple schedules.

In studies of stimulus compounding (1) the stimuli are presented randomly, (2) primary reinforcement is correlated with each stimulus, (3) a specific response is emitted during each stimulus, and (4) the response is necessary to produce the reinforcer. The present experiments assessed the importance of these procedures by (1) presenting light and tone stimuli in fixed order, (2) removing reinforcement (food) during one stimulus, (3) preventing the response (lever pressing) from being emitted, and (4) eliminating the contingency between lever pressing and food. These variables were presented in various combinations within the context of chained and multiple schedules. When the stimuli were combined in the schedule component correlated with each stimulus, the frequency of lever pressing increased in most instances (additive summation). This suggests that the effect of combining stimuli was not closely tied to the specific procedures used in previous experiments. However, presenting the stimuli in a fixed order did have an effect: the level of responding to the compound was generally greatest when the stimuli were combined in the component correlated with the higher frequency of lever pressing to the single stimulus. Additive summation failed to occur consistently when response-independent food was correlated with each stimulus, and when both lever pressing and food were eliminated during one stimulus.

Journal Article↗
PubMed1975

In memoriam.

Explore the source record for details and available documents.

History, 20th Century↗
PubMed1973

Control of 5S RNA synthesis during early development of anucleolate and partial nucleolate mutants of Xenopus laevis.

Ribosomes of all eukaryotes contain a single molecule of 5S, 18S, and 28S RNA. In the frog Xenopus laevis the genes which code for 18S and 28S RNA are located in the nucleolar organizer, but these genes are not linked to the 5S RNA genes. Therefore the synthesis of the three ribosomal RNAs provides a model system for studying interchromosomal aspects of gene regulation. In order to determine if the synthesis of the three ribosomal RNAs are interdependent, the relative rate of 5S RNA synthesis was measured in anucleolate mutants (o/o), which do not synthesize any 18S or 28S RNA, and in partial nucleolate mutants (p(l-1)/o), which synthesize 18S and 28S RNA at 25% of the normal rate. Since the o/o and p(l-1)/o mutants have a complete and partial deletion of 18S and 28S RNA genes respectively, but the normal number of 5S RNA genes, they provide a unique system in which to study the dependence of 5S RNA synthesis on the synthesis of 18S and 28S RNA. Total RNA was extracted from embryos labeled during different stages of development and analyzed by polyacrylamide gel electrophoresis. Quite unexpectedly it was found that 5S RNA synthesis in o/o and p(l-1)/o mutants proceeds at the same rate as it does in normal embryos. Furthermore, 5S RNA synthesis is initiated normally at gastrulation in o/o mutants in the complete absence of 18S and 28S RNA synthesis.

Animals↗