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Biomedical subjects

L Michaels

Publications and source records attributed to L Michaels.

At least 109 records · Page 6Linked to original sources
PubMed1985

The microslicing method in the study of temporal bone changes in the perinatal period: an interim report.

The microslicing method was used to study the temporal bones of 49 perinatal deaths in the gross. X ray of the temporal bones was an important part of the investigation. The principle pathological changes were clearly observed. They were: acute otitis media in two cases; an anterior crural deformity of the stapes in four infants and haemorrhage of the apex of the fundus of the internal auditory meatus in 12. Primitive mesenchymal tissue was frequently seen in the infants of younger gestational age, but had largely disappeared by term.

Ear Diseases↗
PubMed1984

A study of whole organ cancerous larynges to determine resectability by conservation surgery.

Sixty-two extirpated whole larynges containing squamous cell carcinoma were examined by a transverse slicing method to determine whether a partial laryngeal resection would have been feasible. The epithelial origin and sites of invasion of each tumor were recorded. The observations suggested that in one third of the specimens conservation laryngeal surgery could have achieved complete removal of the cancer.

Carcinoma, Squamous Cell↗
PubMed1984

Epidermolysis bullosa letalis in the larynx causing acute respiratory failure: a case presentation and review of the literature.

The case history is presented of a 29-month-old boy with the characteristic skin lesions of epidermolysis bullosa letalis, requiring steroid therapy. After an episode of gastrointestinal haemorrhage, probably caused by the steroids, the child experienced progressive stridor and respiratory failure and died 10 days later. The postmortem findings in the larynx were of marked mucosal inflammation and cystic swelling of the serumucinous glands producing severe narrowing of the supraglottic airway. The laryngeal cysts were thus entirely different in nature to the cutaneous bullae.

Child, Preschool↗
PubMed1983

Benign conditions of the temporomandibular joint: a diagnostic dilemma.

The diagnosis of certain benign conditions affecting the condyle in the temporomandibular joint can be difficult. A spectrum of osteomas, condylar hyperplasia and synovial chondromatosis can all present the same clinical and radiological picture, while the histological appearance may be difficult to interpret and are often misleading. Trauma, local infection or surgery may play a part in the development of these pathologies. A case is reported which clearly illustrates the difficulties of diagnosis of these benign conditions.

Aged↗
PubMed1983

Oculo-auriculo-vertebral dysplasia. A temporal bone study of a case of Goldenhar's syndrome.

A case of oculo-auriculo-vertebral dysplasia is presented, with histopathological findings in the temporal bone and eye, and some radiological features. The syndrome consists of anomalies of the first and second branchial arch derivatives associated with ophthalmic and vertebral anomalies. Although clinical features and radiological findings of oculo-auriculo-vertebral dysplasia are documented in the literature, there have been very few reports of the histopathological findings of abnormal temporal bones. These vary from our own findings. The prominent features in our case are: a small middle ear cleft, an absence of ossicles, an aberrant facial nerve, and dysplastic, short lateral and superior semi-circular canals, as well as a narrow internal auditory meatus.

Cochlea↗
PubMed1983

Midline granulomas.

Explore the source record for details and available documents.

Granuloma, Lethal Midline↗
PubMed1983

A new technique for the study of temporal bone pathology.

A new technique for the study of the temporal bone at autopsy is presented in which thin slices of the fixed bone are prepared on a special cutting machine which preserves the configuration of the delicate anatomical structures. Selected areas are then processed for light microscopy. There is thus opportunity for gross examination, only a short period for immersion in acid for decalcification if required, and special histological procedures may also be carried out. The method is quick and technically easier than serial sectioning and storage of the smaller numbers of sections from each case is less of a problem. Temporal bones which have been perfused through the perilymph within 3 h of death may also be cut in the same way in order to allow removal of samples of membranous labyrinth for surface preparation or electron microscopy, avoiding the need for drilling to reach the membranous labyrinth, and being quicker and less damaging.

Histological Techniques↗
PubMed1983

Squamous papillomas of the larynx in adults. A review of 63 cases.

Sixty-three cases of squamous papillomas of the larynx occurring in adults are presented. Twelve cases started as juvenile papillomas and continued into adult life. Twice as many males as females were in the series. The papillomas were always present on the true vocal cords at presentation, although other parts of the larynx were involved to a variable extent. The symptom of hoarseness gave a good indication as to the state of the larynx during treatment. Malignancy did not develop in patients with papillomas which fulfilled the histological criteria. Papillomas are clusters of thin, cylindrical projections of squamous epithelial covered mucosa with second and even third order branching. Biopsies in 5 cases show papillomatosis of respiratory epithelium, a process which is here described in the larynx for the first time. The prognosis as regards recurrence for 20 patients with solitary lesions was good, for 38 patients with multiple lesions reasonable, but for 5 patients with extensive florid lesions was exceptionally poor.

Adolescent↗
PubMed1983

Role of retraction pockets in cholesteatoma formation.

Temporal bones were obtained from 100 routine cases at post mortem who died of causes other than otological. The tympanic membranes were examined under the operating microscope and retraction pockets were seen and photographed in 12 cases. Radiological examination of these 12 mastoid bones showed a sclerotic mastoid in 8 cases. On serial histopathological examination of the temporal bones there was evidence of old or recent chronic otitis media in each case. In 3 cases a sac with a narrow neck leading to the retraction pocket was seen. In 2 cases squamous epithelial 'pearls' in close proximity to the retraction pockets were seen. The significance of these findings in the pathogenesis of retraction pockets and cholesteatoma is discussed.

Cholesteatoma↗
PubMed1982

The human respiratory nasal mucosa in pregnancy. An electron microscopic and histochemical study.

The ultrastructural and histochemical changes in the respiratory nasal mucosa of thirty pregnant females have been studied. Symptoms-free pregnant females, regardless of the duration of pregnancy, showed glandular hyperactivity, increased phagocytic activity, and increased amount of acid mucopolysaccharides in the ground substance. These changes have been suggested to be due to the rise in the levels of female sex hormones during pregnancy. Pregnant females developing nasal symptoms during pregnancy have been proved by electron microscopy and histochemically to be allergic in origin. This allergy, being not due to the hypersensitization of the patient's own sex hormones, may be due to any of the factors previously mentioned.

Adult↗
PubMed1982

The Mondini defect in Turner's syndrome. A temporal bone report.

The histopathology of the right temporal bone of a 47 year old deaf woman with Turner's Syndrome (gonadal dysgenesis) is described. The appearances are of the Mondini deformity, the cochlea consisting of a single basal turn with a bulbous apical dilatation. The organ of Corti was absent. The remainder of the bony labyrinth save for the cochlear aqueduct was normal. The patient's death was due to a cerebral astrocytoma. Previous reports concerning the co-existence of gonadal dysgenesis, congenital deafness and non-gonadal neoplasia are discussed.

Astrocytoma↗
PubMed1982

Congenital abnormalities of the ear in perinatal deaths.

A study of temporal bone history was carried out on 15 cases of perinatal deaths. Specimens included cases of general abortion, abortion due to rubella, still births and postnatal deaths. In one case that survived for 7 years with congenital hearing loss the clinical and audiological findings were available as well as the temporal bone histology. Ten of the cases had abnormal stapes and 5 had a cochlear duct abnormality ranging from absence of one turn to complete distortion of the normal configuration. The possible role of maternal factors in the production of these abnormalities is discussed.

Child, Preschool↗
PubMed1982

Ventriculosaccular carcinoma of the larynx.

A series of 76 cases of laryngeal carcinoma was examined in transverse slices using a motorized slicing machine. Eleven cases of ventriculosaccular carcinoma were detected by this method and the topography and gross appearances of the tumours in the larynges are described. Microscopy of the tumour indicates a keratinizing squamous cell carcinoma the mode of growth of which seems to be by concentric expansion through the whole margin rather than by invading tongues of tumour. In no case was there invasion of laryngeal cartilages or extension to the surgical cut surface of the specimen. The clinical, radiological and biopsy features in 10 of the 11 patients are described. In follow-up studies, which were 12 years or longer in five patients, none had lymph node metastases or recurrences of the laryngeal carcinoma of any sort. The following features may suggest the diagnosis of ventriculosaccular carcinoma before laryngectomy: (1) a ventricular tumour, (2) a supraglottic bulge above it, (3) a paraglottic swelling on CT scan radiology covered by a smooth laryngeal lining and (4) biopsy appearances of a well differentiated 'folded carcinoma'.

Adult↗
PubMed1981

A malignant carcinoid tumour of the supraglottic larynx.

A rare case of carcinoid tumour of the laryngeal surface of the epiglottis in a 49-year-old woman is presented. This is the fourth report of this tumour in the world literature. The clinical features, and the light and electron microscopical appearances are discussed. The literature and the relationship to other carcinoid tumours is reviewed. Based on this and previously reported cases, recommendations are made as to management.

Carcinoid Tumor↗
PubMed1981

The epithelium and chronic inflammatory cells in scleroma. (An electron microscopic study).

The ultrastructure of 15 cases or rhinoscleroma have been studied. The epithelium showed intercellular edema, a reaction to the polysaccharide coat of intact bacilli, passing through defects in the basal lamina and subsequently inviting polymorph migration. The transitional stages between normal and 'reactive' plasma cells to the formation of the Russell body and the Unna cell were demonstrated, thus supporting the theory of an intracellular formation of the Russell bodies.

Adolescent↗
PubMed1981

Unusual leiomyoma of the nose (leiomyoblastoma): report of a case.

Leiomyomas or benign tumours of smooth muscle origin are extremely rare in the nose, due to the paucity of significant masses of smooth muscle in this region. A review of the literature revealed only six cases of leiomyoma (Fu and Perzin, 1975; Kambayashi, 1978; MacCaffrey et al., 1978; Maesaka et al., 1966; Kotaka and Furuya, 1973) previously reported and no case of nasal leiomyoblastoma. This variety of benign smooth muscle tumour has been mostly described in the gastrointestinal tract and uterus (Stout, 1962). In this paper we report a case of an unusual nasal leiomyoma arising from the middle turbinate. We believe it is the first in the literature.

Child, Preschool↗