Dispensing with the renal diet for dialysis patients.
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Humans↗
Biomedical subjects
L McCann
Publications and source records attributed to L McCann.
Prevention of Unwanted Pregnancy.
These two studies explored the cognitive decision-making process which differentiate effective contraceptors form the ineffective contraceptors (Study 1), and applied these findings to the development and testing of educational and cognitive interventions aimed at a group of sexually active young women at risk of becoming pregnant (Study 2). The results identified factors related to unnecessary contraceptive risk-taking. The interventions changed attitudes and knowledge about contraception in the college population in general and increased effective contraception in the at-risk population of women who were initially using either ineffective methods of birth control or no methods at all.
Contraception↗
The antecedents and prevention of unwanted pregnancy.
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Adolescent↗
Oxidative phosphorylation in Escherichia coli K12. An uncoupled mutant with altered membrane structure.
1. A new mutant strain (AN228) of Escherichia coli K12, unable to couple phosphorylation to electron transport, has been isolated. The mutant allele (unc-405), in strain AN228, was found to map near the uncA and uncB genes at about minute 74 on the E. coli genome. 2. A transductant strain (AN285) carrying the unc-405 allele is similar to the uncA and uncB mutants described previously in that it is unable to grow on succinate, gives a low aerobic yield on limiting concentrations of glucose, has a normal rate of electron transport, is unable to couple phosphorylation to electron transport, and lacks ATP-dependent transhydrogenase activity. 3. Strain AN285 (unc-405) is similar to an uncA mutant, but different from an uncB mutant, in that it is unable to grow anaerobically in a glucose-mineral-salts medium, and membrane preparations do not have Mg(2+)-stimulated adenosine triphosphatase activity. 4. Strain AN285 (unc-405) does not form an aggregate analogous to the membrane-bound Mg(2+)-stimulated adenosine triphosphatase aggregate found in normal cells. In this respect it differs from strain AN249 (uncA(-)), which forms an inactive membrane-bound Mg(2+)-stimulated adenosine triphosphatase aggregate.
Adenosine Triphosphatases↗
Reconstitution of oxidative phosphorylation and the adenosine triphosphate-dependent transhydrogenase activity by a combination of membrane fractions from unCA- and uncB- mutant strains of Escherichia coli K12.
1. Membrane preparations from both uncA(-) and uncB(-) mutant strains of Escherichia coli K12, in which electron transport is uncoupled from phosphorylation, were fractionated by washing with a low-ionic-strength buffer. The fractionation gave a ;5mm-Tris wash' and a ;membrane residue' from each strain. This technique, applied to membranes from normal cells, separates the Mg(2+),Ca(2+)-stimulated adenosine triphosphatase activity from the membrane-bound electron-transport chain and the non-energy-linked transhydrogenase activity. 2. Reconstitution of both oxidative phosphorylation and the ATP-dependent transhydrogenase activity was obtained by a combination of the ;membrane residue' from strain AN249 (uncA(-)) with the ;5mm-Tris wash' from strain AN283 (uncB(-)). 3. Valinomycin plus NH(4) (+) inhibited oxidative phosphorylation both in membranes from a normal strain of E. coli and in the reconstituted membrane system derived from the mutant strains. 4. The electron-transport-dependent transhydrogenase activity was located in the membrane residue and was de-repressed in both the mutant strains. 5. The spatial and functional relationships between the proteins specified by the uncA and uncB genes and the transhydrogenase protein are discussed.
Adenosine Triphosphatases↗
Grateful Med: getting started.
When a local medical library is not available, it is often necessary for physicians to discover alternate ways to receive medical information. Rural physicians, particularly, can make use of a computer program called Grateful Med that provides access to the same literature available to physicians in large cities. This program permits the user to perform database searches on the National Library of Medicine database (MEDLINE), corresponding to the primary index to medical literature, Index Medicus. In this article, we give the procedure for procuring a National Library of Medicine password and for making efficient use of the Grateful Med program.
Computer User Training↗
A primer for users of medical bibliographic databases.
A database is electronic information. Perhaps one of the most important information sources in medicine is that which is accessed electronically through a database named MEDLINE, the core medical literature published since 1966. MEDLINE is sold by three major vendors (BRS, Dialog, and the National Library of Medicine) to information experts and to medical experts. Information experts (librarians) and medical experts (physicians) can access MEDLINE by two different methods. This article discusses both and emphasizes use by the medical practitioner. An annotated guide to database vendors is provided, and guidelines are offered that will assist the physician in selecting equipment and assessing services.
MEDLARS↗