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Biomedical subjects

L Matturri

Publications and source records attributed to L Matturri.

At least 73 records · Page 4Linked to original sources
PubMed1993

Anastomotic disjunction in long-term patent vascular synthetic grafts in Dacron.

This study follows the recently published paper on the in vivo behaviour of patent Dacron vascular prostheses and focuses in particular on anastomotic disjunction. The question of the evolution of anastomoses was tackled by examining its three basic components: prosthetic tissue, suture thread and arterial wall. The authors' observations were based on material taken from reoperations performed between 7 and 18 years after the first graft. These data enable the authors to affirm that the prosthesis undergoes a general physical and chemical deterioration which varies in intensity according to the type of weaving. On the contrary, in the anastomotic zone this phenomenon is not intense enough to jeopardize the anchorage of the suture thread since the original weft does not show any loss of compactness. In spite of surface morphological deterioration of various intensity, the suture threads maintain satisfactory mechanical properties and structural integrity. The artery wall in the anastomotic zone shows a massive degeneration in terms of its true anatomic structure responsible for the rupture of the suture rima. On the basis of these results the authors conclude that this phenomenon represents the "Achilles' heel" of anastomotic junction.

Aged↗
PubMed1993

[Cardiac block caused by metastasis of lung adenocarcinoma to the bundle of His].

It is well known from autopsy series that metastatic tumors of the heart can be found in 1.5% to 21% of patients with malignancies and the incidence of cardiac metastases is showing a gradual increase in recent years. The most common cause of metastatic heart disease is bronchial carcinoma followed by carcinoma of the breast, pleural mesothelioma, malignant melanoma, leukemia and lymphoma, in decreasing order of frequency. However metastatic cancer to the heart is not commonly diagnosed prior to death. Atrial extension has been reported as a common route of local spread in patients with bronchial carcinoma, but cardiac conduction system invasion is infrequent. The purpose of this report is to describe an unusual case of pulmonary adenocarcinoma that presented with cardiac manifestations mimicking atrioventricular (AV) block. This AV block was corrected by pacemaker. Chest radiography and bidimensional echocardiography didn't visualize important lesions. The cardiac findings at autopsy were remarkable not only for the severity of epicardial, myocardial and endocardial involvement, but for the metastatic implants into the His bundle and for the elective and wide infiltration of bifurcating His bundle. On addition histological examination revealed neoplastic emboli in the myocardial lymphatics. No valvular involvement was noted. Technical annotation: histological examination of the conduction system of the heart has been carried out on serial sections with the technique devised by one of the present authors. Bichromic (hematoxylin-eosin) and trichromic (Heidenhain-azan) stainings have been routinely employed.

Adenocarcinoma↗
PubMed1993

[Biodegradation of dacron vascular prostheses. Physico-chemical, histological, morphometric and ultrastructural study].

The paper deals with study of long-term stability as far as concerns Dacron vascular prostheses in woven and knitted double velour. Among our vascular prostheses case-reports, we evaluated three of them explanted after 11, 12, 20 years; all of the prostheses were patent. Chemical-physical, histopathological and ultrastructural analysis have been carried on in order to evaluate in vivo ageing of the examined prostheses. The results all indicate strong alterations of the original properties related to double velour of knitted prostheses and weak alterations of woven one.

Aged↗
PubMed1992

Long-term histopathologic evaluation of human expanded skin.

Forty-two patients operated on by skin expansion have been contacted after a mean time of 25 months from the last surgery. Two biopsies have been taken from the expanded area of each patient. In 12 patients it has been possible to obtain a similar sampling from the opposite, nonexpanded area of the body. The samples underwent optic microscopy and cell kinetic and DNA content investigations. The epidermal structure of the followed-up skin, compared with the skin of the opposite side of the body, looks normal. The mitotic activity of the epidermal cells has returned to the values of preexpanded skin. The dermis shows a low degree of elastosis and zonal fragmentation of elastic fibers. The hypodermis, where the expander capsule was removed during the last surgery, does not show an accentuated fibrosis.

Adolescent↗
PubMed1992

[Prognostic implications of the proliferation index (H3-TdR-labeling index) and ploidy in neuroectodermal tumors (astrocytomas and glioblastomas)].

Kinetic cellular methods were used in 53 cases of various sizes of astrocytomas and glioblastomas to obtain reliable prognostic information. Kinetic analysis revealed a wide variation of proliferative activity, with a gradual increase of the mean value from the most differentiated astrocytomas to glioblastomas. DNA content was significantly correlated with the degree of histological differentiation. Chromosomic patterns, which were detected in a few cases, were generally aspecific. The sole recurrent alteration in the karyotype was a small metacentric marker. The comparison of results obtained with the follow-up of patients showed that the labeling index offers a more accurate estimate of the proliferative potential of individual tumours, and thus of the probability of survival, than histological diagnosis and the evaluation of other biological parameters such as ploidy and karyotype.

Adolescent↗
PubMed1992

Recurrent chromosome alterations in transitional cell bladder carcinomas.

A karyotype study was performed in 42 cases of transitional cell bladder carcinoma. The results, confirmed by DNA content evaluation, showed a prevalence of near-diploid modes not related to the histologic grade of differentiation. Nonrandom alterations were represented by monosomy of chromosome 13 and 22, trisomy of chromosome 7 and deletion of chromosomes 6 and 11. These anomalies allow the identification of different sub-groups of tumors, each with its own biological characteristics of aggressiveness. Prognosis was particularly poor in cases with monosomy of chromosomes 13 and 22 but more favourable in poorly differentiated carcinomas with trisomy of chromosome 7.

Carcinoma, Transitional Cell↗
PubMed1992

[Arrhythmogenic Takayasu disease].

The Authors report a case of Takayasu disease in a woman who died at the age of forty-six, in whom the histological examination of the cardio-vascular system revealed giant cells granulomatous arteritis localized in the aortic arch and collateral arteries; endocarditis and granulomatous coronaritis. The bases of arrhythmogenic alterations, in this study, take into account the thrombosis of the conduction system arteriolar vessels and the phlogosis extending to the cardiac plexus.

Adult↗
PubMed1991

[Clinical significance of nuclear DNA content in human gastric tumors. A static cytometry study in 87 cases].

In recent years the abnormal DNA content of cancer cells and the ploidy model have played an important role in biological and medical research aimed at achieving a more accurate diagnostic and prognostic assessment. Static cytometry was studied in histological sections using an image analyser which enabled the DNA content of cancer cells coloured using Feulgen's method, the elective method for nucleic acids, to be evaluated. A high percentage of aneuploidy in human gastric tumours was found to be correlated with a low degree of histological differentiation (G3), with tumoral invasion of the lowest tissue strata and neighbouring lymph nodes, and with a negative prognosis. The practical clinical application of DNA evaluation therefore allows cases which evolve more rapidly since they possess a greater tumoral aggressiveness to be identified (aneuploid tumours).

Adenocarcinoma↗
PubMed1991

Densitometric evaluation of DNA content in colorectal cancer.

The aim of the present study was to provide information on the DNA content in colorectal tumours using densitometric techniques on histological samples and correlating the findings with age, sex, histological grade, stage, presence or absence of lymph-node metastasis and survival time. The distribution of DNA values was significantly related with the histological grade. Dukes' stage and infiltration of the peritumoral lymph-nodes. The distribution of DNA values was not significantly correlated with age and sex. From the data obtained in this study it can be concluded that evaluation of DNA content in colorectal adenocarcinoma can be used as a prognostic test that is complementary to histological investigation. The ploidy can provide information for classifying the degree of malignancy and can also be used to determine which tumours are biologically most aggressive.

Adenocarcinoma↗
PubMed1991

Histopathology of specialized and ordinary myocardium and nerves in chronic Chagas disease, with a morphometric study of inflammation and fibrosis.

Chagas disease, in the chronic phase, is known to be characterized by cardiac failure, and/or arrhythmias. To assess the involvement of the conduction system and of the working myocardium, morphometric and immunohistochemistry studies have been carried out on 4 autoptic hearts of chronic chagasic myocardiopathy. The characterization of interstitial infiltrates was performed by lymphocyte immunophenotyping with immunocytochemical techniques. These infiltrates were more prominent in the working myocardium and in the left branch of the His bundle. The infiltrates consisted of about 50% of macrophages and 50% of T-lymphocytes. Mast cells would not play a role in the chronic stages of the disease. Eosinophils were present in no more than the 5% of the inflammation. The fibrosis, especially of the conducting system seems to be facilitated by an impaired lymphatic outflow, whereas the evidence of neuroganglionic involvement was variable.

Cardiomegaly↗
PubMed1991

Cell kinetics and DNA content (ploidy) of human skin under expansion.

One question which still remains unanswered concerning expansion of human skin is whether expansion simply stretches the skin or whether it induces a real neo-production of epithelium. To evaluate the proliferative activity of the human skin before and after expansion, we performed an autoradiographic study and a densitometric analysis on sections of skin biopsy from 11 patients. The results of the cellular kinetic study showed that expansion induces an increase in the epidermal proliferative activity. On the contrary, the densitometric analysis did not show a parallel increase of the proliferating cells after expansion. This discrepancy is discussed in terms of the modified morphology of the tissue. The proliferative activity of skin in the back region increases more than in that of the neck. Preliminary results have shown that the proliferative activity increases with time of expansion in days. The presence of a low percentage of cells with altered DNA content indicates, at least over the short term, the absence of dysplastic processes in expanded skins.

Adolescent↗
PubMed1991

[Syndrome of multiple cholesterol embolism after parenteral streptokinase therapy of acute myocardial infarct: description of an autopsy case].

Syndrome caused by multiple cholesterol embolism can be seen as a complication in patients affected by acute myocardial infarction, treated with streptokinase thrombolytic therapy. Fragments of atheromatous plaques may embolize and occlude arterial vessels in different organs. Only the histological examination can give a reliable diagnosis, because symptomatology changes according to different localization of the emboli. An emblem case of this pathology observed by the Authors is described in this article.

Cholesterol↗
PubMed1991

[Atheromatous material mobilization syndrome after thrombolytic therapy with streptokinase in acute myocardial infarct].

Streptokinase fibrinolysis is a widely accepted and applied therapy in acute myocardial infarction with good clinical and ECG results. Nevertheless this therapy is not devoid of complications that sometimes can be very serious. In this paper the Authors report the case of a patient 52 years old who has been treated with streptokinase for an acute myocardial infarction with good ECG results but that about eight hours later showed an important cholesterol embolization syndrome with visceral and lower extremity lesions. The patient died about 36 hours later. The Authors emphasize the necessity to exclude aortic aneurysm before using thrombolytic agents and to evaluate carefully the possibility to abstain from this procedure in the presence of certain aneurysmal lesions.

Cholesterol↗
PubMed1990

[Are synthetic prostheses really inert?].

Five cases of long-term complications of a homogeneous series of 78 aorto-iliac-femoral by-passes in knitted Dacron velour observed between 1976 and 1988 are reported. The cases were aneurysm of a prosthetic branch and pseudoaneurysms of aortic and femoral anastomoses. The paper concerns not so much the presentation of the causes, recognised by most Authors, that might have determined the ongoing pathology as the observation of a histologic situation not previously described: namely the presence of macrophages which attack Dacron fibres and fragment them.

Aged↗
PubMed1989

Cytogenetic analysis in 28 radically operated non-small-cell lung cancer: preliminary considerations.

Twenty-eight radically operated non-small-cell lung cancer patients were analyzed with regard to chromosomal assessment and DNA content: in 13 cases, different quantitative/qualitative chromosome alterations were found. In particular, in 12 cases marker chromosomes and cytogenetic abnormalities in euploid cells were demonstrated. The prognostic value of these findings will be aim of further studies.

Aneuploidy↗