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Biomedical subjects

L Matos

Publications and source records attributed to L Matos.

At least 19 recordsLinked to original sources
PubMed1998

[The role of hyper-homocysteinemia in the etiology of some vascular diseases].

About 5% of population have a highly, while other 15% a moderately elevated plasma homocysteine level. Hyperhomocysteinemia may be responsible about 10-20% of coronary artery, 40% of cerebrovascular and 60% of peripheral vascular diseases. There in an inverse relationship between folate, cobalamin and pyridoxine intake or blood level and plasma homocysteine level. In addition, the intake of these three B vitamins can reduce high plasma homocysteine level. Folate-folic acid seems to be the most important in homocysteine reduction due to the compensation of thermolabile methylenetetrahydrofolate reductase insufficiency, however, a milder impact of cobalamin any pyridoxine (mainly following a methionine load test) is also proved. There are possibilities to reduce risk associated with elevated homocysteine: e. g. dietary supplementation or food fortification. In Hungary bread enriched by folic acid, cobalamin and pyriodixine might reduce rate of vascular diseases due to hyperhomocysteinemia.

Cerebrovascular Disorders↗
PubMed1997

[Effect of betaxolol on blood pressure and heart rate in mild to moderate hypertension].

The efficacy and safety of daily 20 mg betaxolol monotherapy was investigated in mild-moderate essential hypertension in a four week long, open label, single blind trial (with a placebo run-in). Twenty one patients of both sexes were enrolled. The systolic blood pressure in the supine position decreased from 158 to 142 mmHg, the diastolic blood pressure from 101 to 89 mmHg. The mean systolic values of the 24 hours ambulatory blood pressure monitoring decreased from 136 to 126 mmHg, the mean diastolic values from 87 to 80 mmHg. All decreases in blood pressure were significant. The reduction of the heart rate (80/min vs 63/min) was also significant. The decrease in blood pressure during daytime was significant, during night it was moderate. The blood pressure- and heart rate reducing effect of betaxolol was detectable however in the second half of the night, before wake-up. No side effect was recorded.

Adult↗
PubMed1996

[Genetic counseling in a case of Takayasu arteritis].

Two cases affected with Takayashu arteritis are presented. The adult probanda born in 1960 after genetic counselling and appropriate prenatal care had a healthy liveborn boy. Her previous six pregnancies were terminated on the basis of forced medical reason. The infant probanda died at the age of 4 months with the features of sudden infant death syndrome (SIDS). Pathohistological examination detected her Takayashu arteritis. It seems to be the youngest published case in the international literature and Takayashu arteritis may be the rare cause of SIDS.

Adult↗
PubMed1995

Cisapride compared with ranitidine in the treatment of functional dyspepsia.

OBJECTIVE: To compare the efficacy of the prokinetic drug cisapride and the antisecretory agent ranitidine in relieving symptoms of functional dyspepsia, as well as their effect on the recurrence of symptoms after the discontinuation of treatment. DESIGN: A randomized double-blind parallel-group trial of cisapride 30 mg daily and ranitidine 300 mg daily given for 2, 4 or 8 weeks, followed by a 4-week drug-free follow-up of the patients with a good or excellent response. Rescue antacid tablets were allowed only if pain was unbearable. PATIENTS: A total of 203 patients (99 cisapride, 104 ranitidine) with symptoms of functional dyspepsia for more than 4 weeks, after the exclusion of organic disease by endoscopy and sonography or radiology. RESULTS: Cisapride and ranitidine improved the symptoms of diffuse epigastric pain, postprandial epigastric fullness, epigastric distension, belching, heartburn, regurgitation, and nausea when compared with baseline. Pain at night and gastric discomfort also greatly improved. Cisapride produced a greater reduction in epigastric pain (P = 0.07) and epigastric distension (P = 0.03) scores than ranitidine. Both drugs were equally effective in reducing the concomitant reflux-like symptoms of heartburn and regurgitation. At week 8, 87% of cisapride patients versus 61% of ranitidine patients had an excellent or good result. The deterioration of symptoms during the follow-up phase was limited in both groups. However, after the withdrawal of medication there was a greater reduction in scores in the cisapride group than in the ranitidine group for diffuse epigastric pain (P = 0.05), epigastric distension (P = 0.002), the cluster of six symptoms of epigastric discomfort (P = 0.05), and the cluster of all nine upper gastrointestinal symptoms (P = 0.06). Adverse events occurred in 15 cisapride patients and 18 ranitidine patients, and two of the ranitidine patients were withdrawn from treatment. CONCLUSIONS: Although cisapride and ranitidine both improved the symptoms of functional dyspepsia, cisapride was superior to ranitidine, particularly on the combined evaluation of the response to treatment and the recurrence of symptoms.

Adult↗
PubMed1995

Reclosure of the open abdomen.

BACKGROUND: The open abdomen technique for the treatment of diffuse peritonitis has gained acceptance. Our approach has been to use the zipper technique with daily irrigations. Once the abdominal problem has resolved, the mesh and zipper are removed. Surgeons are reluctant to reoperate on patients with such prior treatment because of the anticipation of a hostile abdomen. Our study is a retrospective review of 12 patients who were treated with the open abdomen technique. At a later date, they underwent elective reoperation. STUDY DESIGN: The charts of 12 patients were reviewed. After initial injury, the patients were in the surgical intensive care unit. Reoperations were performed nine months (mean) after discharge from this facility. The reasons for reoperation were closure of enteric fistula (five patients) and closure of an ostomy (seven patients). The abdominal wall was reconstructed in nine patients. In the other three patients, the abdomen was entered through a lateral incision and the bowel was reanastomosed. RESULTS: All of the patients survived. There were five complications. Two patients had ischemic skin grafts successfully treated by hyperbaric oxygen therapy (HBO). Two patients had ischemic skin flaps that were covering mesh. They responded to HBO with minimal slough of superficial tissue. One patient had a low output fistula that closed after two weeks of total parenteral nutrition. CONCLUSIONS: A history of an open abdomen is not a contraindication to later operation. Bowel continuity can be restored and abdominal wall reconstruction can be performed safely. This can be done as early as three to four months after recovery from the original injury.

Abdomen, Acute↗
PubMed1993

Pharmacokinetic study of bisaramil in man.

Six healthy volunteers received an oral dose of 100 mg and an intravenous dose of 35 mg of bisaramil in a cross over study. Plasma concentrations were measured by HPLC. Bisaramil was eliminated from the plasma with a half life of 8.6 +/- 1.8 h and 9.0 +/- 4.1 h after iv. and oral administration, respectively. The mean total plasma clearance and volume of distribution were found to be 70 +/- 13.1 l/h and 864 +/- 204 l, respectively. The calculated oral bioavailability of bisaramil in tablets amounted to 56 +/- 20%.

Adult↗
PubMed1993

Visual recovery from radiation-induced optic neuropathy. The role of hyperbaric oxygen therapy.

Optic neuropathy resulting in permanent visual loss is an infrequent delayed complication of radiation therapy. Hyperbaric oxygen therapy (HBO) has been used to treat such a complication, but its efficacy is controversial. We report a patient who presented with radiation-induced optic neuropathy 17 months after irradiation for a left maxillary antrum melanoma. HBO fully reversed visual loss in the more recently involved eye, and slightly improved vision in the earlier affected eye.

Female↗
PubMed1986

[Effect of heart diseases on premature labor].

The connection between the different heart diseases and premature births was studied. The incidence of premature births was more frequently in heart cases, while fetal retardation was similar to that of the control with exception of the group of the patients with acquired and operated heart diseases. Perinatal fetal mortality during birth was similar to the normal cases but higher in fetal retardation as in the general population of the pregnant women. In a worse condition of heart function the rates of premature birth, perinatal mortality and fetal retardation are more frequent than in a better circulatory state.--The contradiction found in the literature on this theme may have its cause that the effect of heart diseases affecting premature birth were not considered in its functional severity.

Adolescent↗
PubMed1981

A simple nonparametric procedure: the MAXIMIN test.

The MAXIMIN test is based on the principle that if two samples were drawn from the same population much overlapping of the values of the two groups would occur. However, if the two samples are drawn from two different populations, the values of Group 1 are expected to accumulate at one end of the numerical scale, whereas those of Group 2 will accumulate the other end. The sum of nG1 (the number of values in Group 1 greater than the greatest value in Group 2) and nG2 (the number of values in Group 2 smaller than the smallest value in Group 1) gives the MAXIMIN value (MV). The higher MV is, the smaller is the probability that the two samples contain different values by chance. The MAXIMIN test may provide a simple alternative to the t test as well as to other parametric and some nonparametric procedures for evaluating clinicopharmacological results.

Analysis of Variance↗
PubMed1981

[Congenital heart diseases and pregnancy (author's transl)].

The maternal foetal prognosis was studied on the basis of data which had been recorded from 56 pregnancies or deliveries of 46 women with congenital cardiac defects. Functional changes of circulation, such as hypoxia, pressure and volume overload, and conduction disorders, were assessed, with reference being made to the classification of the American Heart Association (AHA). In that context, the patients were repeatedly examined during pregnancy and followed up further through two years after delivery. --Maternal prognosis in pregnancy and, consequently, oxidation were found to depend on the kind of congenital heart disease. Reference is made to the favourable role played by cardiac surgery in preventing cardiac complications. Premature birth and retarded foetal development have occurred repeatedly, depending on severity of a congenital heart disease. Enzymological-histological tests are likely to suggest that such consequences were primarily attributable to strongly impaired placental energy production on account of inadequate haemodynamic conditions of the mother. --Proper prognostication of pregnancy will depend for high standards on adequate supervision of delivery, prophylactic use of caesarean section, individual assessment of any single case, and efficient teamwork of obstetricians and cardiologists.

Adult↗