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Biomedical subjects

L Mathy

Publications and source records attributed to L Mathy.

7 recordsLinked to original sources
PubMed2006

A prospective randomised multicentre study comparing continuous and intermittent treatment with celecoxib in patients with osteoarthritis of the knee or hip.

OBJECTIVE: To compare the effects of continuous and intermittent celecoxib treatment in patients with knee or hip osteoarthritis in flare. METHODS: In this 24-week, prospective, randomised, double-blind, placebo-controlled study, patients were randomly assigned to receive continuous (n = 62) or intermittent (n = 61) treatment with celecoxib 200 mg once daily. The primary efficacy end point was the area under the curve (AUC) of the change in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total scores between baseline and week 24 divided by the time interval. Secondary end points included the percentage of days with intake of the flare drug, the AUC of the change in the WOMAC total scores, the mean change from baseline in the WOMAC scores, and the patient's and physician's global assessment of osteoarthritis. RESULTS: There were no significant differences between patients randomised to continuous or intermittent treatment in the primary end point or most of the secondary end points, although a consistent trend supporting continuous treatment was observed. The percentage of days with intake of the flare drug was significantly lower (p = 0.031) in the group receiving continuous versus intermittent celecoxib. Both treatment regimens were well tolerated. CONCLUSION: The results of this pilot study indicate a potential clinical difference between continuous and intermittent treatment with celecoxib, and may be useful in designing future trials. A larger trial on both efficacy and safety outcomes is required for conclusive evidence in favour of either continuous or intermittent treatment.

Aged↗
PubMed1999

[Primary malignant lymphoma of the spine: clinical aspects and therapeutic advances].

Malignant lymphomas are occasionally encountered in the spine, where they are usually secondary deposits. The authors report the case of a primary non-Hodgkin lymphoma of the L1 vertebra in whom surgical treatment (two operations and double approach) was followed by radiotherapy and chemotherapy. The diagnosis is often made at a late stage, when neurological deficits produced by epidural compression become evident. The surgical treatment is only palliative but has several goals: obtaining a biopsy, improving the neurological symptoms through decompression, stabilizing and "rebuilding" the spinal column; it is performed using posterior, anterior or combined approaches which are discussed. The combined surgical, radiotherapeutic and polychemotherapeutic treatment is associated with a 5-year survival rate of 60-80%. Such a prognosis justifies the risk of surgery which will lead to a stable and lasting reconstruction.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1999

Comparison between clinical evaluation and ultrasonography in detecting hydrarthrosis of the knee.

OBJECTIVE: To assess the validity of the clinical detection of knee hydrarthrosis compared to ultrasonography (US). To assess the differences of results for both clinical and US tests when they are done by independent investigators. To assess the effect of a previous clinical evaluation on the US diagnosis. METHOD: The clinical and US examinations were scored using a 3 point scale. In 50 symptomatic patients, 82 knees underwent clinical and US evaluations by the same physician. Two independent observers clinically and echographically tested 22 other knees (11 patients). Finally, in another series of 20 knees (10 patients), the first investigator performed clinical testing before the US evaluation, while the other did the US with no previous clinical evaluation. RESULTS: Between the clinical and US evaluations, agreement was moderate (kappa = 0.508), but statistically significant (p<0.001). The relationship between the 2 investigators for clinical evaluation was slightly weaker (kappa = 0.446, p = 0.032). Possible (score 1) or definite (score 2) clinical knee hydrarthrosis sensitivity was 79/100% and specificity 25/78%, respectively. In contrast, US studies from 2 independent observers were strongly related (kappa = 0.902) and were not modified by a previous clinical evaluation. CONCLUSION: Clinical knee hydrarthrosis detection is less accurate and reproducible than US detection.

Humans↗
PubMed1989

Prenatal diagnosis of cystic fibrosis.

Cystic fibrosis is the most common autosomal recessive genetic disorder in the Caucasian population (1:2000-1:4000) (Warwick, W. J. (1978) Helv. Paediatr. Acta 33, 117-125). This defect is characterized by chronic obstructive pulmonary disease, pancreatic exocrine insufficiency and abnormally high perspiration electrolytes in most patients (Talamo et al. (1985) In: The metabolic basis of inherited diseases, pp. 1887-1917). The elevated electrolyte level provides the most reliable diagnostic test for cystic fibrosis homozygotes. Although prospects for cystic fibrosis patients have improved, genetically homozygous cystic fibrosis is effectively a lethal disease. Because of the seriousness of the disease, many families with one affected child desire a prenatal diagnosis when a second pregnancy occurs. Despite extensive research, the biochemical basis of cystic fibrosis remains unknown. Secondary effects on microvillar enzymes allow second trimester diagnosis (17-18 weeks of gestation (Brock, D. H. J. (1983) Lancet II, 941-943). First trimester prenatal diagnosis for cystic fibrosis became possible with DNA technology. Application of polymorphic marker loci to problems of prenatal diagnosis and carrier-testing is discussed.

Alkaline Phosphatase↗
PubMed1987

Cystic fibrosis: typing 48 German families with linked DNA probes.

Two hundred and thirty five subjects from 48 German cystic fibrosis (CF) families were typed for restriction fragment length polymorphisms (RFLPs) detected by the probes pmet H, pmet D, and pJ 3.11, known to be tightly linked to the CF gene. Gene and haplotype frequencies suggest a linkage disequilibrium with the CF locus. The analysis of the predictive value of this typing in individual CF families indicates that the combined use of these probes provides a powerful diagnostic system both for carrier detection and prenatal diagnosis. In 33 out of 48 families carriers and non-carriers could be identified, and in 26 of these 33 families prenatal diagnosis could discriminate between affected and unaffected offspring.

Chromosome Mapping↗