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Biomedical subjects

L Mathieu

Publications and source records attributed to L Mathieu.

At least 37 records · Page 2Linked to original sources
PubMed1988

Significance of solitary spine abnormalities on technetium-99m bone imaging.

Solitary abnormalities located within the spine from 75 bone images with Tc-99m MDP were reviewed. For the sake of convenience, patients were grouped in three classes of age: 15-50, 51-65, and 66-90 years. In 67 cases, the diagnosis was apparent from clinical studies, x-ray examinations, or biopsies. In eight cases, no diagnosis could be made. The maximum percentage of lesion sites were within the lumbar spine (45 cases). Metastatic lesions were the most common solitary abnormalities within the spine (29.3%). Osteoporosis was second (24%) with the maximum percentage in age group 66-99 years (83%) with a greater female predominance (67%).

Adult↗
PubMed1987

Skeletal distribution and biochemical parameters of Paget's disease.

Quantitative bone scans were performed with 99mTc-EHDP in 170 untreated pagetic patients (93 men, 77 women; mean age, 65.4 years). The distribution of 863 pagetic skeletal locations was analyzed. Bone scans demonstrated 8.3% more pagetic sites than roentgenograms. The extent of Paget's disease was evaluated in each patient by a scintigraphic skeletal index. This index correlated with serum alkaline phosphatase (SAP) and urinary hydroxyproline (HyPro) levels, and also with hypocalcemic acute response to calcitonin. The correlation of SAP with an index of activity (extent index adjusted by uptake ratios) was better than with the nonadjusted index. Only 30.6% of pagetic sites were responsible for clinical symptoms. No correlation was found between age and skeletal index of the disease.

Adult↗
PubMed1986

Bone imaging in a case of chronic fluorine intoxication with mineral water.

A patient with chronic fluorine intoxication from mineral water demonstrated an abnormal intense uptake of Tc-99m MDP in the whole spine, the bone metaphyseal regions, and the sternum ("tie sternum"). Results of a bone biopsy revealed an intense osteomalacia and a high fluorine concentration. Bone imaging performed one year after the patient stopped drinking mineral water was normal.

Adult↗
PubMed1985

[Chorioretinopathy caused by migration of caterpillar hairs. Apropos of 2 cases].

Caterpillars cause many ocular lesions by a pathogen agent coming from their coating: the hairs. These can enter into the eye ball and migrate in the ocular tissues; a secondary inflammatory reaction to the foreign body will appear. This reaction is due to the hairs themselves as foreign body, but also partly to their contents: a liquid toxin which contains proteins, lipids and other components. The morphological configuration of the hair favours its migration in the tissues. Among the different lesions observed, chorio retinopathies are not very frequent, but their clinical aspect is quite characteristic and they are easier to recognize when they are associated with intra crystalline caterpillar hairs. Two cases of chorio retinopathies had been recorded. Both had hairs inside the lens and important hyalitis. One had the very characteristic "track-shaped" scars in the eye-fundus. The other had a focal chorio retinitis above the inferior temporal artery and developed a retinal tear. Local and general corticotherapy was applied, but the effect was not adequate. Vitrectomy was performed in the two patients with a good functional result. This seems to prove that vitrectomy may be useful for the important hyalitis secondary to the intra ocular migration of caterpillar hairs.

Adolescent↗
PubMed1981

Correlation of urinary pesticide metabolite excretion with estimated dermal contact in the course of occupational exposure to Guthion.

Exposure to and absorption of Guthion 50 W.P. (azinphos-methyl) were estimated in orchardists from the Okanagan Valley in British Columbia who were involved in mixing, loading, and application with ultra-low volume air blast equipment. Air monitoring and patch techniques were used to estimate exposure, and alkyl phosphate excretion and cholinesterase inhibition were measured to estimate absorption. All workers were issued with standardized cotton shirts, trousers, and long-sleeved coveralls. All wore half-face respirators, gloves, boots, and hats. Eight wore rubberized protective clothing in addition. The indirect method of measuring urinary metabolites appeared to be the most sensitive. All workers had quantifiable levels of alkyl phosphates following exposure, and 24-h urine samples provided a more reliable estimate than first morning voids. A high correlation was observed between 48-h alkyl phosphate excretion and amount of active ingredient sprayed. A fluorescent tracer was added to the tank along with the Guthion. The finding of Guthion on patches beneath the clothing was confirmed by the presence of the tracer on the skin. With the ultralow-volume application used in this study, the rubberized clothing did not appear to be significantly more protective than the heavy coverall. There was no significant depression of either red blood cell or serum cholinesterase activity in any workers.

Air Pollutants, Occupational↗
PubMed1980

[Treatment of Paget's disease of bone with ethane-1 hydroxy-1, 1 diphosphonate at low dosage (author's transl)].

Fifty-one patients with Paget's disease were treated during 6 months with ethane-01 hydroxy-1, 1 diphosphonate (EHDP, etidronate) in doses of 5 mg/kg/day. The drug was most effective in relieving pain, at the same time diminishing the uptake of pagetic lesions on quantitative bone scans and lowering by almost 70% the abnormally high serum alkaline phosphatase levels and 24-hour hydroxyproline urinary levels. Histologically, the resorption surfaces and the number of osteoclasts per mm2 of bone tissue were significantly reduced. On follow-up, the improvement persisted for at least one year after treatment was discontinued. EHDP was well tolerated clinically and biologically, and on histological sections no accumulation of osteoid tissue due to impaired mineralization was seen. EHDP at the 5 mg/kg/day dose appears to be effective in the treatment of Paget's disease.

Adult↗
PubMed1979

Effects of disodium dichloromethylene diphosphonate on Paget's disease of bone.

19 patients with Paget's disease were treated orally for 6 months with disodium dichloromethylene diphosphonate. 1600 mg/day (10 patients) significantly reduced urine hydroxyproline, serum alkaline phosphatase, urine calcium, and the number of pagetic bone osteoclasts. Tetracycline double labelling revealed undisturbed bone mineralisation. There was improvement on quantitative bone-scans and bone pain diminished. There was a transient increase in parathyroid hormone level in 13 of the 19 patients during treatment, which was associated with a high serum 1,25 (OH)2D3. No adverse clinical side-effects have been observed and biochemical remission has persisted for 9 months.

Administration, Oral↗
PubMedDate not supplied

[Cecal volvulus].

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Abdomen, Acute↗