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Biomedical subjects

L Martini

Publications and source records attributed to L Martini.

At least 271 records · Page 15Linked to original sources
PubMed1969

Non-steroidal antifertility agents affecting brain mechanisms.

Many non-steroidal agents prevent ovulation by acting on the nervous structures that control the secretion of gonadotrophins. Information on the neuroendocrine factors involved in the process of ovulation in mammals is presented in this paper and is then used as the background for explaining the mode of action of drugs which inhibit ovulation through an effect on the central nervous system. Such drugs are found among the following classes of compounds: CNS depressants, tranquillizers, cholinergic blocking agents, and adrenergic blocking agents. Although it is unlikely that any of the specific agents discussed in this paper will have clinical application, because of associated behavioural effects, the knowledge gained by studying the mode of action of these compounds indicates pathways to follow in the search for new anti-ovulatory drugs.

Acetylcholine↗
PubMed1968

Brain receptors sensitive to indole compounds: function in control of luteinizing hormone secretion.

The placement of melatonin and of 5-hydroxytryptophol in the median eminence of castrated male rats is followed 5 days later by a significant decrease in pituitary stores of luteinizing hormone. Pituitary reserve of this hormone is also depleted after the implantation of melatonin, 5-hydroxytryptophol, and 5-methoxytryptophol in the reticular formation of the midbrain. It is suggested that these indole compounds, which are normally synthesized in the pineal gland, may intervene in the control of the secretion of luteinizing hormone, possibly by acting on specific receptors localized in the median eminence and in the midbrain.

Animals↗