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Biomedical subjects

L Martinez

Publications and source records attributed to L Martinez.

130 records · Page 8Linked to original sources
PubMedDate not supplied

cis-Dichlorodiammineplatinum(II) and DTIC in malignant melanoma.

Twenty-nine patients with advanced malignant melanoma were randomized to receive DTIC at a dose of 200 mg/m2 iv on Days 1-5 and cis-dichlorodiammine-platinum(II) at a dose of 40 mg/m2 iv on Days 1 and 4, repeated every 4 weeks (group A), or the same drugs plus procarbazine at a dose of 75 mg/m2 orally daily on Days 1-8 and vincristine at a dose of 1.4 mg/m2 iv on Day 1 (group B). These drugs were generally well-tolerated, but five of 16 patients in group A and six of 13 patients in group B required dose modification for either hematologic or renal toxicity. There were six objective responses among 16 patients in group A including one complete regression, while there were two objective responses among 13 patients in group B.

Adult↗
PubMedDate not supplied

A comparative study of two third-generation anti-hepatitis C virus ELISAs.

The sensitivity and specificity of two third-generation screening tests for the detection of antibody to hepatitis C virus (anti-HCV) was evaluated in a side-by-side study (Abbott HCV EIA 3.0/Ortho HCV ELISA 3.0). Specimens that were reactive in either ELISA were then retested by the other ELISA, and confirmed by RIBA-3. The screening of 15,540 serum samples from healthy blood donors showed a significantly lower number of reactive cases tested by Ortho (21 out of 8,805, 0.24%), than tested by Abbott (35 out of 6,735, 0.52%). In the side-by-side comparison, we found that significantly (p = 0.005) more Ortho-positive samples were also reactive in Abbott (14/21, 66.6%), than in Abbott followed by Ortho (7/35, 20%). Moreover, the RIBA analysis revealed a significantly (p = 0.014) higher number of RIBA-positive specimens among those reactive in Ortho 10/21 (47.6%), than among those reactive in Abbott 6/35 (17.2%), thus the former provides a greater positive predictive value. However, we did not observed differences in the sensitivity between Abbott and Ortho, because all RIBA-positive samples demonstrated reactivity in both ELISAs.

Blood Donors↗