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Biomedical subjects

L Marshall

Publications and source records attributed to L Marshall.

At least 109 records · Page 6Linked to original sources
PubMed1982

The concentration of 13,14-dihydro-15-keto prostaglandin F2 alpha and prostaglandin E2 in peritoneal fluid of infertile patients with and without endometriosis.

Prostaglandin F2 alpha (PGF2 alpha) metabolite (13,14-dihydro-15-keto PGF2 alpha) and prostaglandin E2 (PGE2) were assayed in the cul-de-sac fluid aspirated from 15 patients with endometriosis, in saline peritoneal washings of 5 patients with unexplained infertility, and in 5 control subjects. The fluid from the cul-de-sac of patients with endometriosis showed wide variations in the concentrations of PGF2 alpha metabolite and PGE2. There was no correlation between the concentration of these prostaglandins (PGs) and the stage of the cycle. Saline peritoneal washings from patients with unexplained infertility had significantly higher concentrations of PGF2 alpha metabolite than the control subjects. The concentration of PGE2 in the saline peritoneal washings was higher in the group with unexplained infertility than in the control group; however, the difference was not significant. The concentration of PGF2 alpha metabolite and PGE2 in the peritoneal saline washings from patients with unexplained infertility were no different from the concentrations of these PGs in the peritoneal fluid (PF) from patients with endometriosis. PG concentration in PF of infertile patients with or without endometriosis is a new variable for evaluation in these patients.

Adolescent↗
PubMed1982

Testosterone : testosterone estradiol binding globulin ratio in evaluating hirsute women.

Testosterone : testosterone estradiol binding globulin (TEBG) ratio is evaluated in 35 hirsute women (age 12 to 38 years), and 14 healthy nonhirsute normal controls (age 21 to 40 years). This is an attempt to emphasize the significance of TEBG in evaluating hirsute women. This is a significant negative linear correlation between the weight of the patients and TEBG concentrations (r = 0.414, P less than 0.05). There is negative linear correlation between TEBG and serum free testosterone concentration that reached significance only in the hirsute nonobese. T:TEBG ratio is significantly high in hirsute women compared to the controls. T:TEBG ratio shows a significant positive linear correlation with free testosterone concentration. In addition, T:TEBG ratio is a direct simple method of evaluating hirsute women. Demulen and Dexamethazone treatment produced a significant fall in T:TEBG ratio in hirsute women.

Adolescent↗
PubMed1981

Auditory processing in aging listeners.

Many aspects of auditory processing in aging listeners are poorly understood. Methodological problems encountered with the aging population, ranging from ear canal collapse to a conservative criterion, have rarely been considered in past research. The relation between pure-tone thresholds and other aspects of auditory functions is unclear. There have been few studies of frequency and temporal analysis in aging listeners. There is disagreement on the effect of age on speech discrimination abilities in various listening conditions, and the cause of speech perception problems in aging listeners has not been adequately investigated. Areas of importance for clinical consideration and auditory research with aging listeners are discussed.

Acoustic Impedance Tests↗
PubMed1981

Ovulatory dysfunction in patients with endometriosis.

The incidence of ovulatory dysfunction (anovulation, oligo-ovulation, and luteal phase defect) in 103 patients with endometriosis and infertility was found to be 27.2%. Ovulatory dysfunction was found to occur at a slightly higher age group than the patients with normal ovulatory pattern (p less than 0.02). Prior use of oral steroidal contraceptives does not increase the incidence of ovulatory dysfunction. In addition, there is no correlation between the duration of infertility, and te incidence of ovulatory dysfunction in this group of patients with endometriosis. This report suggests an association between endometriosis and ovulatory dysfunction in some patients, which adds to the etiology of their infertility. It is also suggested that the diagnosis of endometriosis should be suspected in cases of unexplained infertility, even if the pelvic examination does not have any positive objective findings.

Adolescent↗
PubMed1980

Some characteristics of an early protein (ICP 22) synthesized in cells infected with herpes simplex virus.

In Vero cells incubated at 40 degrees C or treated with azetidine at 37 degrees C, synthesis of a polypeptide ('C') of apparent mol. wt. 66000 was stimulated. It was not phosphorylated and was found in the cytoplasmic fraction of cell lysates. In cells infected with herpes simplex virus type 1 (HSV-1) in the presence of azetidine, synthesis of cellular proteins, including polypeptide C, was suppressed and infected cell polypeptides ICP 4, 0, 22 and 27 (apparent mol. wt. 170000, 120000, 75000 and 60000, respectively) were made. All were phosphorylated and accumulated in the nucleus. Messenger RNA for the same four polypeptides was made in cells infected in the presence of cycloheximide. Thus, ICP 22 is distinct from cellular polypeptide C and is probably a virus-specific alpha polypeptide, although it differs from alpha ICP 4, 0 and 27 in that its rate of synthesis does not decline rapidly when later polypeptides are produced. It is modified after synthesis in at least two steps, the second of which may require a later virus-specific polypeptide. In cells infected with HSV-2 the synthesis of a polypeptide analogous to ICP 22 could not be detected.

Animals↗
PubMed1980

Vitamin D metabolism during recovery from severe osteitis fibrosa cystica of primary hyperparathyroidism.

Serum concentrations of 1,25-dihydroxyvitamin D [1,25-(OH)2D] and immunoreactive parathyroid hormone were measured before and for 7 months after the removal of a 15-g parathyroid adenoma from a 44-yr-old woman with primary hyperparathyroidism and severe osteitis fibrosa cystica. Despite the fall in parathyroid hormone levels from preoperative levels of 20 to 1--2 ng/ml after surgery (normal, up to 1.2 ng/ml), serum 1,25-(OH)2D concentrations remained markedly elevated (156 pg/ml) preoperatively; 124 pg/ml 17 weeks postoperative), approaching the normal range (18--56 pg/ml) only after 5 months (65 pg/ml). Hypocalcemia and hypophosphatemia persisted despite oral 1,25-(OH)2D3 (1 and 2 micrograms/day) and large doses of (oral and iv) calcium gluconate (up to 30 g/day). Healing of the skeletal lesions, reversal of the myopathy, and return of 1,25-(OH)2D circulating levels to normal corresponded to the time when serum phosphate became normal. The stimulus for the persistently elevated serum 1,25-(OH)2D levels may have been hypocalcemia per se, low serum phosphate, or an unidentified signal that paralleled serum phosphate, as serum PTH levels remained in the upper normal range throughout the recovery period.

Adenoma↗
PubMed1980

Loudness growth of musically complex stimuli.

Young adults (N = 11) with musical training, and with previous practice in the use of direct magnitude estimation of loudness for pure tones, judged the loudness of 3 orchestral excerpts each lasting 15-25 sec, varied in 5 -db steps over a 35 -db range. Excerpt I was relatively constant in both pitch and loudness; Excerpt II varied in loudness but did not change greatly in pitch; and Excerpt III changed both in pitch and loudness. The slopes of power functions for loudness judgments as a function of SPL fell within the usual range for pure-tone and for white-noise stimuli, as did indexes of determination; but both measures differed significantly from those in the literature for continuous speech. Apparently the acoustic variability in speech is an insufficient explanation for the difference between speech and non-speech stimuli in these areas, a finding which points to the contribution of non-acoustic parameters, such as semantic meaning, in loudness judgments for speech.

Acoustic Stimulation↗
PubMed1978

Characteristics of calcification in tumors of the pineal gland.

Thirty-two cases of proved pineal tumor were analyzed. Calcification was seen in 75%. The size, character, and position of the calcification were useful indicators of abnormality on plain-film evaluation. Fray's cranioangle method was more sensitive than Oon's method in determining abnormal position of the calcified pineal tumor on the lateral skull film. Most calcifications were displaced postero-inferiorly or inferiorly, which can be explained by obstructive hydrocephalus or direct tumor expansion.

Adolescent↗
PubMed1975

Anticipatory middle-ear reflex activity from noisy toys.

Middle-ear reflex activity was measured in 14 listeners in response to visual and acoustic exposure to each of seven noisy toys (such as a cap gun, party horn, cow bell, and so forth). Anticipatory middle-ear reflex (AMER) activity was a common occurrence. Normal middle-ear reflex generally occurred after the sound exposure. AMERs generally occurred in the two seconds prior to sound exposure but as early as 10 seconds before sound exposure. Loudness ratings and exposure SPLs were obtained. The presence of acoustically evoked middle-ear (ME) reflex activity and AMERs to the toys was generally unrelated to SPL or reflex threshold. Many reflex responses occurred in response to exposure SPLs below reflex threshold and with low anticipated loudness rating.

Auditory Perception↗
PubMed1973

Purification and properties of dihydrofolate reductase from cultured mammalian cells.

Dihydrofolate reductase was purified quickly and simply from small quantities of cultured mammalian cells by affinity chromatography. On gel electrophoresis of the purified enzyme, multiple bands of activity resulted from enzyme-buffer interaction at low but not high buffer concentration. A Ferguson plot (Ferguson, 1964) showed that this heterogeneity was due to a charge difference with no alteration in the size of the enzyme. Stimulation of enzyme activity by KCl, urea and p-hydroxymercuribenzoate, and inhibition by methotrexate and trimethoprim, showed only minor differences between the various enzymes.

Cell Line↗