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Biomedical subjects

L Marianowski

Publications and source records attributed to L Marianowski.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

Adenosine receptor antagonism causes inhibition of angiogenic activity of human ovarian cancer cells.

Angiogenesis, new blood vessels development, is an important process involved in ovarian cancer growth and metastasis. Adenosine is a known mediator of angiogenesis in hypoxic tissues. Theobromine, adenosine receptor antagonist, exerts antiangiogenic properties in many types of tumors in Balb/c mice cutaneous angiogenesis assay. The aim of the present study was to evaluate the mechanism of its action. We showed that theobromine inhibits angiogenic activity of ovarian cancer cells as well as CD45 positive lymphocytes isolated from peritoneal ascitic fluid of ovarian cancer patients. Using synthetic adenosine receptor antagonists: 8-phenyl-theophylline and 8-cyclopentyl-1,3 dipropylxantine we established that antiangiogenic properties of theobromine are dependent on its interaction with A2 adenosine receptor. Our observations were confirmed in full suspensions of ascitic cells as well as in isolated cancer cells and CD45 lymphocytes. We postulate that A2 receptor antagonism may diminish angiogenesis induced by hypoxia in different cancer tissues and may find a place in future cancer therapy.

Angiogenesis Inhibitors↗
PubMedDate not supplied

Cornual pregnancy--a case report.

Ectopic pregnancy is a rare phenomenon in mammals. The most common localization is an oviduct, ovary and abdominal cavity. Confirmation of the ectopic pregnancy is always a difficult medical problem. The diagnosis is mainly based on the patient's history and gynecological examination. This paper concerns a case report of cornual pregnancy, diagnosed in the 20th week of pregnancy. The diagnostic difficulties and procedures, surgical management and the patient's and newborn's outcome was described.

Adult↗
PubMedDate not supplied

Diagnosis and treatment of sigmoidal endometriosis--a case report.

Intestinal endometriosis is a rare but clinically significant complication. The most commonly involved sites are the rectosigmoid (up to 73%) and rectovaginal septum (13%). A case of a 53-year-old woman with intestinal endometriosis located in the sigmoid colon is presented with symptoms of pelvic pain and rectal bleeding. The diagnosis was established by means of colonoscopy which was performed 3 times before laparotomy. Bowel resection and pathologic study are necessary to relieve the symptoms and avoid neglecting a malignant tumor or other lesions. The postoperative course was uneventful and the patient was discharged after 13 days.

Colonoscopy↗
PubMedDate not supplied

Role of cytokines in pathogenesis of endometriosis.

Sampson's theory stating that endometrial cells and fragments desquamate during the menstrual period are transported through Fallopian tubes into the peritoneal cavity where they implant, proliferate and develop into endometriotic lesions is generally accepted [1]. Accumulating data suggest that deficient immunity against retrograde endometrium during menstruation may be involved in the pathophysiology of endometriosis. Recent studies in women with endometriosis have demonstrated functional changes in several immunologic components in the peritoneal fluid as well as in sera of those patients. It was shown, for instance, that a wide pattern of cytokines are involved during endometrial cells implantation, proliferation and forming of endometriotic lesions. Those factors play a critical role in decreased immunologic surveillance, recognition and destruction of ectopic endometrial cells and possible facilitation of the implantation of ectopic endometrial tissues. The present review summarises the current knowledge on the role of different cytokines in the pathophysiology of endometriosis.

Ascitic Fluid↗
PubMedDate not supplied

A study of circadian rhythms of estriol secretion in the third trimester of gestation complicated by gestosis and intra-uterine growth retardation (IUGR).

The circadian changes in serum estriol concentration in the case of gestosis (at 30-36 weeks gestation) and intra-uterine growth retardation-IUGR (at 28-36 weeks) were examined. The control group consisted of pregnant patients without placental insufficiency at 26-34 weeks gestation. No circadian rhythms of estriol secretion was found in patients with gestosis and IUGR, whereas such a rhythm was confirmed in normal pregnancies. The evaluation of circadian changes in estriol concentration in the third trimester of gestation may be useful when diagnosing chronic placenta insufficiency.

Circadian Rhythm↗
PubMedDate not supplied

Albumin and packed red blood cells in the treatment of severely isoimmunised pregnancies.

The most effective method of treatment of severe cases of fetal haemolytic disease are intrauterine intravascular transfusions. In some hydroptic cases however, the administration of only packed red blood cells produces unsuccessful results. We found that albumin supplementation paralleled with PRBC injection significantly increases the effectiveness of intravascular treatment.

Albumins↗
PubMedDate not supplied

[Intrauterine blood transfusions in the treatment of severe serologic conflict].

Efficacy of the intraperitoneal and intravenous blood transfusions guided ultrasonographically was evaluated in severe cases of fetal hemolytic disease due to Rh conflict. It was shown, that survival rate of fetuses without generalized edema is two-fold higher in the group treated with intraperitoneal blood transfusions in comparison with the control group. It was found, that the proportion of erythrocytes containing HbA in umbilical blood of newborn is related to the number of intraperitoneal transfusions. One has to underline the failure of such a treatment in features with generalized edema. In such case intravenous blood transfusion is a method of choice.

Blood Transfusion, Intrauterine↗