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Biomedical subjects

L Manzi

Publications and source records attributed to L Manzi.

13 recordsLinked to original sources
PubMed1978

[Notes on respiratory and cardiac pathology in an unpublished letter of Maurizio Bufalini].

An unpublished letter written by Maurizio Bufalini on 8th January 1820 describes a clinical case of considerable gravity characterized by asthma with pleural effusion and "dilatation of the vena cava". On this basis, the state of knowledge of asthma in that period, particularly in relation to heart diseases, is reviewed. Following a careful examination of the letter, the possibility that M. Bufalini may have been a forerunner of the modern concept of cor pulmonale is suggested.

Asthma↗
PubMed1974

Formation of acetoacetate from 3-hydroxy-3-methylglutarate by rat liver and isolation of a mitochondrial coenzyme A-transferase activity involved.

1. Formation of acetoacetate from 3-hydroxy-3-methylglutarate was observed in the perfused rat liver. Production of 3.5mumol of acetoacetate/h per g of tissue was obtained. 2. Formation of acetoacetate was catalysed mainly by the mitochondrial fraction of the homogenized liver, at a rate of 62nmol/h per mg of protein. 3. Experiments with hydroxy-[3-(14)C]methylglutarate demonstrated that the acetoacetate formed was derived mainly from this compound. 4. A mitochondrial transferase activity catalysing the transfer of a CoA molecule from succinyl-CoA (3-carboxypropionyl-CoA) to hydroxymethylglutarate was shown. The K(m) value for hydroxymethylglutarate was 5x10(-3)m.

Acetoacetates↗