ACTH effects on aldosterone production and mitochondrial ultrastructure in adrenal gland cultures.
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Adrenal Glands↗
Biomedical subjects
L Manuelidis
Publications and source records attributed to L Manuelidis.
Studies with electron microscopic autoradiography of thyroxine 125 I in organotypic cultures of the CNS. I. Fixation of thyroxine 125 I.
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Animals↗
Studies with electron microscopic autoradiography of thyroxine 125 I in organotypic cultures of the CNS. II. Sites of cellular localization of thyroxine 125 I.
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Animals↗
An autoradiographic study of the proliferation and differentiation of glial cells in vitro.
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Animals↗
Adrenal gland in tissue culture.
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Adrenal Glands↗
I-125 labelled thyroid hormones in cultured mammalian nerve tissue.
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Animals↗
Scrapie-associated fibrils in Creutzfeldt-Jakob disease.
Scrapie of sheep, and Creutzfeldt-Jakob disease (CJD) of man belong to a group of transmissible encephalopathies which have been successfully transmitted to a variety of hosts. In susceptible hosts, these diseases are characterized by progressive degeneration of the central nervous system leading inevitably to death. The agents responsible for these diseases have not yet been identified, but they exhibit similar physicochemical characteristics. Abnormal fibrils designated 'scrapie associated fibrils' (SAF) have been observed in synaptosomal preparations of scrapie infected brain. They have never been observed in various types of control animals. We report here that SAF are present in CJD brain fractions in the experimentally transmitted disease as well as in a few naturally occurring human cases of CJD. SAF are also present in spleen extracts of animals experimentally infected with scrapie or CJD. This close association of SAF with these two diseases and two different tissues (brain and spleen) known to contain titres of infectivity, suggest that the SAF are: (1) a unique pathological response to the disease or (2) the infectious agent of these diseases.
Animals↗
Suggested links between different types of dementias: Creutzfeldt-Jakob disease, Alzheimer disease, and retroviral CNS infections.
Several lines of investigation identify common features of Creutzfeldt-Jakob disease, Alzheimer disease, and retroviral CNS infections. We discuss salient neuropathological, genetic, transmission, and transformation properties that suggest there may be common pathways in the pathogenesis of dementias. We also briefly present potential retroviral mechanisms that may be implicated in all of these dementias.
Acquired Immunodeficiency Syndrome↗