Search PubMed⌕ Search

Biomedical subjects

L Mandel

Publications and source records attributed to L Mandel.

At least 91 records · Page 5Linked to original sources
PubMed1991

Pneumoparotid: a case report.

Pneumoparotid is an unusual condition resulting from air being forced into the parotid ductal system. When it develops, it is a result of increased intraoral air pressure. Diagnosis is based on the etiologic factor, palpatory evidence of tissue emphysema, the escape of frothy saliva from the involved duct, and the sialographic finding of retained ductal air and ductal infection.

Emphysema↗
PubMed1991

Polycystic parotid disease: a case report.

A case report of a 14-year-old girl, presumed to have PPD, is presented. Those manifestations of this patient's disease that can be added to the classic picture of PPD include a decreased salivary flow rate and a sialochemistry that reflects a mild chronic parotitis. In addition, cysts and sialoliths were demonstrated grossly rather than microscopically.

Adolescent↗
PubMed1991

Parotid enlargement in children seropositive for human immunodeficiency virus: imaging findings.

We investigated the clinical, immunologic, and imaging features of parotid enlargement in 10 children seropositive for human immunodeficiency virus (HIV) who were infected prenatally. In seven patients, sonography revealed many small hypoechoic areas suggestive of lymphoid infiltration. In three older children, large anechoic areas suggesting lymphoepithelial cysts were present. The lesions probably represent generalized lymphoid infiltration akin to pulmonary lymphoid hyperplasia, although only two of our patients had radiologic evidence of pulmonary lymphoid hyperplasia. Four of five of the children with parotid enlargement who had immunologic studies were phenotypically HLA-DR5, an immunophenotype associated with improved immune response, occurring in less than one in four in the normal population. This suggests that painless parotid enlargement may be a good prognostic sign in HIV-seropositive children. Parotid enlargement was found in 10 HIV-positive children from 6 months to 11 years old. All except one were infected prenatally.

Antibodies, Viral↗
PubMed1991

[The gastrointestinal post-irradiation syndrome].

In the recent years, more attention is paid by radiobiologists to both prevention and therapy of a relatively less studied gastrointestinal postirradiation syndrome (GPS). Moreover, the increase in interest in GPS is motivated with the requirement as to obtain the decrease in action of ionizing radiation on the intestinal mucosa at making radiotherapy of abdominal or pelvic region. The GPS occurs consequently to the affected abdominal region or all the organism with ionizing radiation. Its approximal doses from 10 to 100 Gy (gamma) are critical for the survival of intestinal mucosa, especially that of jejunum and ileum. Under the threshold of a single and total dose from 6 to 10 Gy, the intestinal mucosa may usually regenerate, and the survival depends mainly on the preservation or restoration of hemopoietic activity of blood forming tissues. The main pathogenetic GPS factor resides in the afflication of stem cells of mucosal crypts. The intestinal epithelium stops to be fluently replaced after the irradiation. The motion arrests of epithelial cells from crypts to the apex of villi. The elderly cells undergoes degradation, and after several days the denudation of mucosa occurs with possible distortion of deeper layers of intestinal wall. The intestinal microflora is involved in the pathogenesis both directly and indirectly. Amongst the former events is ranged the invasion of distorted mucosa in compromised both local and systemic immunity. Indirectly, the intestinal microflora is GPS associated by stimulating mitotic activity in crypts, therefore more cells are in the radiosensitive phase. In germ-free animals there is a significant decrease in mitotic activity of crypts, and the migration time of epithelial cells from crypts to the apex villi is twice more prolongated, what induces possible restoration of active center after the irradiation. The GPS also results in disorder of metabolic processes which are conditioned with intestinal mucosa. Its typical manifestation resides in the wash-out of mucus, decreased resorption of nutrients and loss of water and minerals into the intestinal lumen. The GPS-related are another disorders of the organism, those of liver and kidney apparently induced due to the intoxication with catabolic products. The microflora has been stated to be involved in GPS by the experiments on germ-free animals. In the absence of microflora, the survival is greater in duration. After a total pigs irradiation with 10-30 Gy, more than two times survival prolongation occurs. The abdominal irradiation with 12 Gy results to the death of only conventional pigs, whereas those germ-free show a survival.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMed1990

Ontogeny of MHC class II antigens in pigs.

Cells constitutively expressing MHC class II antigens have been studied in the course of prenatal development in the Minnesota miniature pig. Frozen sections, cell suspensions and peripheral blood mononuclear cells were examined by using the HL-40 monoclonal antibody cross-reactive with a light chain determinant of the SLA-D molecule (MHC class II porcine antigen). It could be demonstrated that the yolk sac contained cells expressing SLA-D antigens as early as the 24th day, the liver and the spleen on the 39th day of gestation. Splenic cells bearing SLA-D molecules formed periarteriolar structures. Except the spleen, peripheral blood, lymph nodes, bone marrow and intestinal wall were the main sites of SLA-D expression in the perinatal period of the pig.

Animals↗