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Biomedical subjects

L Magos

Publications and source records attributed to L Magos.

At least 109 records · Page 6Linked to original sources
PubMed1970

The effects of carbon disulphide exposure on brain catecholamines in rats.

1. Rats exposed to 2.0 mg/1. carbon disulphide (CS(2)) in the inspired air for 2 days, 4 h a day, showed a 13% decrease in their brain noradrenaline concentration and a 16% increase in their brain dopamine concentration.2. After exposure for 5 or 10 days there was a further decrease in the concentration of noradrenaline in the brain, but brain dopamine returned to the control level.3. In animals treated intraperitoneally with 2.0 mg/kg reserpine and exposed 2 and 3 days later to 2.0 mg/1. CS(2) for 4 h per day, the brain dopamine concentration showed a 77% increase compared with the unexposed reserpinized animals, but the noradrenaline concentration remained unchanged.4. The dopamine concentrations in the adrenals after 10 days' exposure to 2.0 mg/1. CS(2) were 67% to 100% higher than in the control animals. In reserpinized rats, 2 days' exposure to CS(2) nearly trebled the dopamine content of adrenals.5. Exposure to CS(2) had no effect on the tyrosine concentration in the brain, and there was no change in the brain monoamine oxidase (MAO) activity. Tyrosine in the brain showed a 30 to 96% increase in concentration and MAO activity, using kynuramine as substrate, showed an approximately 5% increase 0.5 to 2 h after the subcutaneous administration of 500 mg/kg sodium diethyldithiocarbamate.6. CS(2) at 10(-2)M or lower concentrations had no inhibitory effect on the brain MAO activity in vitro. Diethyldithiocarbamate inhibited MAO at 10(-2)M, but not at 10(-3)M or lower concentrations.

Adrenal Glands↗
PubMed1969

Combined effect of sodium maleate and some thiol compounds on mercury excretion and redistribution in rats.

1. (+)-Penicillamine in a dose of 193 mumoles/kg given subcutaneously twice a day on the sixth and seventh days after the administration of 100 mug mercury increased the urinary excretion of rats more than the equimolar dose of N-acetyl-(+)-penicillamine but less than 2,3-dimercaptopropanol 48.3 mumoles/kg.2. Sodium maleate in a dose of 156 mumoles/kg given on the sixth and seventh days after the mercury did not influence mercury excretion or redistribution. Sodium maleate in the same dose increased considerably the effect of (+)-penicillamine on the urinary excretion and redistribution of mercury. It increased the effect of N-acetyl-(+)-penicillamine only slightly. There was a tendency to decrease the effect of 2,3-dimercaptopropanol.3. All the complexing agents decreased the kidney content of mercury and increased the liver and blood concentration of mercury. These changes were highest with 2,3-dimercaptopropanol. The combination of sodium maleate with (+)-pencillamine caused higher mercury excretion and lower kidney content but a smaller increase in the liver and blood mercury contents than 2,3-dimercaptopropanol.

Animals↗