alpha-Glucosidase inhibitors. New complex oligosaccharides of microbial origin.
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Biomedical subjects
Publications and source records attributed to L Müller.
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2393 cases of myocardial infarctions autopsied during the period from 1.1. 1951 until 31. 12. 1969 in our Institute were scored for aneurysm and rupture of the cardiac wall as well as for partietal thrombosis and endocardial fibrosis, and analysed concerning frequency and distribution of sex. Aneurysm of the ventricle walls was present in 23.94 per cent of myocardial infarctions. Most of the aneurysms were found in the posterior wall of the left ventricle. Callous infarctions showed more aneurysms than fresh myocardial lesions. A rupture was present in 31.82 per cent of acute aneurysms and in 4.53 per cent of old aneurysms. Parietal thromboses we found in 13.92 per cent of all infarctions. In 14.21 per cent of all myocardial infarctions endocardial fibroses were present. Parietal thromboses and endocardial fibroses were significantly most frequent in infarctions of the right ventricle.
Completing former examinations the paper deals with the influence of different methods of gastric operation on abdominal vascularization. Typical alterations found by selective coeliac and mesenteric angiography are demonstrated. They include deficiency of arteries, changes in calibre and in the course of the great vessels, alteration of the vascularization of the head of the pancreas. It becomes evident, that the various effects are subject to preoperative anatomical situation and different operative methods.
The autopsy reports of the Pathological Institute Erfurt of the period from 1. 1. 1951 until 31. 12. 1969 were scored for cases of myocardial infarction which were analyed concerning frequency and distribution of age, and sex, resp. The informations were transferred to punched cards and processed with electronic data equipment. In 8.26 per cent of all autopsies (males 10.32 per cent, femals 5.78 per cent) a myocardial infarction was present. During the period of nineteen years a significant increase of the myocardial infarctions was observed. Callous infarcts were more frequent than fresh and relapsing. Most of the infarcts were found in the posterior wall of the left ventricle.
28978 autopsy reports of young (after the 14th year of age) and adult patients autopsied during the period from 1.1 1951 until 31. 12 1969 were scored for atherosclerotic changes of the aorta and the large arteries. The informations were transferred to punched cards and processed with electronic data equipment. The methods of the statistical evaluation are described. 52.96 per cent of the cases revealed an aortic atherosclerosis. 17.96 per cent showed an atherosclerosis of the cerebral arteries, 31.16 per cent of the cases had atherosclerotic changes of the kidneys. All groups of diseases showed an increase during the observation period. No sex differences were detected.
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In order to compare 5 different radioimmunoassays (RIA's) and their results we determined the digoxin concentration in the serum of 186 patients and point out some sources of error. We consider the following points important: 1. There were found varying results in the determination of digoxin concentration in patient's sera using different RIA's. 2. One of the essential reasons for these differences are discrepancies of the RIA standards which belong to each kit. 3. It should be required that the control standard is equal to all RIA's. 4. Each laboratory which carries out digoxin determinations should, in collaboration with the clinic, work out and announce its own guide-line values for the RIA used in regard to the optimal therapeutic range and also to overdoses.
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