Presented here is a modification of a previously developed, computed, semiautomated system for quantifying the amount of CSF and tissue on brain CT scans. The technique automatically strips skull from brain and applies a two-dimensional high-pass filter to reduce spectral-shift artifact. The resultant images are presented along with the raw images, section by section, on a screen for fluid-tissue differentiation by a human scorer. This is accomplished by adjusting a one-bit display of the filtered image until a satisfactory separation threshold is found. Data can be summed within or across sections to provide measures of CSF volume in specific regions of interest such as the ventricles and sulci. A major advantage is the improved accuracy of sulcal measurement. This method has been applied to scans of 57 community volunteers, 20-84 years old. High correlations have been established between rankings performed by an experienced clinician and automated rankings (r = 0.88 with rankings based on ventricular size, and r = 0.83 with rankings based on sulcal size). Furthermore, significant correlations were found between computed measures of ventricular size and age and between sulcal widening and age.

Adult↗

PubMedDate not supplied

Pseudocyst of spinal cord on metrizamide ct.

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Cysts↗

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CT in brain density determination.

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Brain↗

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Changes on computed cranial tomography with aging: intracranial fluid volume.

A semiautomated computer analysis was developed to estimate fluid volumes in each hemicranium from computed tomography scans. The method was used to estimate total ventricular and sulcal fluid in 123 normal subjects aged 23-88 years. A wide range of normal values was found. The trend was for the estimated ventricular and sulcal fluid volumes to remain relatively constant until age 60 and then to increase at an increasing rate thereafter. Ventricular enlargement occurred in the absence of sulcal enlargement and vice versa. The estimate of the volume of the ventricles was related to skull size. When this was taken into account, the size of the ventricles showed no sex difference. The cranial cavity was larger in men than in women, and, in both genders, the left hemicranium and the left ventricle were larger on the average than their right counterparts. The limitations of computed cranial tomography as a quantitative tool are discussed in detail.

Adult↗