Search PubMed⌕ Search

Biomedical subjects

L M Wolf

Publications and source records attributed to L M Wolf.

At least 73 records · Page 4Linked to original sources
PubMed1978

[Prolonged treatment with acebutolol: surveilance of ocular status (author's transl)].

A very through ocular examination was made in 48 hypertensive patients treated for 18 months with acebutolol in a daily dose of between 400 and 2400 mg. Abnormal symptoms in the form of a prickling sensation were seen in two cases. Microscopic punctate lesions of the conjunctive were seen in 9 subjects, either with the Bengal Pink or fluorescein tests. These very slight microscopic lesions were found in general only in the region of the palpebral slits, a zone normaly exposed to microtrauma, which decreases the value of this finding. The results of a Schirmer test were considered to be abnormal in six patients. These ocular abnormalities were generally mild and it could not be shown conclusively that they were related to treatment with acebutolol. Ocular surveillance, with examinations repeated every six months, indicated the absence of any harmful effect on the eye of prolonged used of acebutolol in the treatment of hypertension.

Acebutolol↗
PubMed1975

[Treatment of arterial hypertension with acebutolol. Double-blind study with placebos].

Acebutolol, a cardioselective beta-blocker, was studied at doses of 600 to 800 mg in a double-blind trial against placebo in 33 patients with essential hypertension. A moderate reduction in the arterial pressure was seen with placebo, but the pressure was greatly reduced by treatment with acebutolol (p less than 0,01). The heart rate was unchanged after placebo and was reduced by about 10 p.cent by acebutolol. Similarly plasma renin activity, in both lying and standing subjects, was not changed by the placebo, but it was greatly reduced by acebutolol. In the 33 patients studied, the arterial pressure returned to normal in 13 cases (39 p.cent), an improvement was obtained in 12 cases (36 p.cent) but in 8 cases (24 p.cent) the hypertension was not modified by acebutolol. The tolerance to acebutolol was excellent in all cases. No relationship was found between the hypotensive effect of acebutolol and the heart rate or its augmentation induced by orthostatism nor with the levels of plasma renin activity.

Acebutolol↗
PubMed1975

[Results of the treatment of essential arterial hypertension following prolonged (24 months administration of acebutolol)].

Acebutolol, a new cardioselective blocking agent, has been used to treat essential hypertension during two years in 56 patients. The initial dosage was 600 mg a day and was sufficient in the majority of patients. We have observed a perfect control of arterial blood pressure in 69 p.cent. In 10 p.cent of our patients arterial blood pressure decreased and the mean decrease was 25 mm Hg. In 21 p.cent there was no effect of the treatment. Tolerance was very good.

Acebutolol↗
PubMed1975

[Fasting with muscular exercise: change in body weight and nitrogen balance].

Amongst a group of 27 obese patients subjected to a 10 day fast (250 cal. with 22 Gms protein), 11 picked at random also followed a muscular exercise programme- the others serving as controls. This physical activity was well accepted and tolerated without problems. Weight loss was similar in both groups but the daily nitrogen balance in those patients performing muscular activity was less negative and tended to become positive more rapidly than in the control group. The loss of active muscle mass by protein catabolism as a result of fating was significantly less in the muscular activity group. This may indicate that muscular activity is useful in aiding adaptation to fasting and may orient weight loss preferentially towards fat mass.

Adipose Tissue↗