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Acquired Immunodeficiency Syndrome↗
Biomedical subjects
L M Walters
Publications and source records attributed to L M Walters.
Purified methoxychlor stimulates the reproductive tract in immature female mice.
Methoxychlor is an estrogenic pesticide currently used as a substitute for DDT. The estrogenic effects of 98% pure methoxychlor or base-washed pure methoxychlor were examined on reproductive organs of immature mice and compared to control and estradiol-treated mice. Within 24 hours of birth, neonatal mice received 14 daily intraperitoneal injections of one of the following chemicals: sesame oil only, 10.0 micrograms of 17-beta estradiol, or 0.05 mg, 0.5 mg, or 1.0 mg of 98% pure methoxychlor, or 1.0 mg base-washed 98% pure methoxychlor. Equal doses (1.0 mg) of 98% pure or base-washed methoxychlor stimulated the reproductive organs of immature females such that the effects closely resembled those seen after estradiol treatments. In comparison to control mice, these pesticide treatments also induced precocious vaginal opening, persistent vaginal cornification, increased reproductive tract weights, and epithelial hypertrophy in both the vagina and uterus. However, only estradiol treatments significantly elevated albumin levels in the uterine fluid of the immature mice while the highest methoxychlor doses significantly increased the uterine cell heights when compared to all other groups.
Albumins↗
Use of recombinant canine granulocyte colony-stimulating factor to decrease myelosuppression associated with the administration of mitoxantrone in the dog.
Ten dogs were given mitoxantrone at a dose of 5 mg/m2 body surface area intravenously. Recombinant canine granulocyte colony-stimulating factor (rcG-CSF) was administered subcutaneously daily for 20 days after an infusion of mitoxantrone in five of these dogs to determine the effect of the hematopoietic growth factor on the duration and severity of myelosuppression. The median neutrophil counts dropped below normal (less than 3,000/uL) for 2 days in the dogs that received rcG-CSF, and for 5 days in the dogs that received only mitoxantrone. Four of five dogs not treated with rcG-CSF and none of those receiving rcG-CSF developed serious neutropenia (less than 1,500/uL). The neutrophil counts were significantly (P less than 0.05) higher in the rcG-CSF treated dogs at all time points except before the administration of the colony-stimulating factor, and the sixth day after the mitoxantrone was administered. These findings demonstrate that rcG-CSF is capable of reducing the duration and severity of mitoxantrone-induced myelosuppression.
Animals↗
Alterations in lipoprotein profiles in dogs with lymphoma.
After a 12-hour fast, blood samples were obtained from 31 dogs with previously untreated lymphoma. Blood samples were also collected from 16 of these dogs after up to 5 treatments with doxorubicin (30 mg/m2 intravenously every 3 weeks). All 16 dogs underwent complete remission. Five dogs were re-evaluated after relapse and after overt signs of cancer cachexia had become clinically apparent. Samples were assayed for 8 quantitative parameters: total cholesterol (T-CH) and total triglyceride (T-TG) concentrations, and the concentration of cholesterol and triglyceride in each of the three major lipoprotein fractions, very-low-density lipoprotein (LDL-CH and LDL-TG), and high-density lipoprotein (HDL-CH and HDL-TG). The results were compared with those from 20 healthy control dogs of similar weight and age before and 3 weeks after being given one dose of doxorubicin (30 mg/m2 intravenously). The administration of doxorubicin to control dogs resulted in a significant (P < .05) decrease in T-CH, LDL-CH, and HDL-CH, as well as a significant increase in VLDL-TG and HDL-TG. When compared with untreated controls, untreated dogs with lymphoma had significantly higher concentrations of VLDL-CH, T-TG, VLDL-TG, LDL-TG, and HDL-TG, and significantly lower concentrations of HDL-CH. HDL-TG and VLDL-TG concentrations from dogs with lymphoma were significantly increased above pretreatment values after relapse and development of overt signs of cancer cachexia.(ABSTRACT TRUNCATED AT 250 WORDS)
Animals↗