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Biomedical subjects

L M Taylor

Publications and source records attributed to L M Taylor.

At least 163 records · Page 9Linked to original sources

Muscle activity during function and its correlation with craniofacial morphology in a sample of subjects with Class II, Division 1 malocclusions.

To evaluate the relationship between craniofacial morphology and jaw muscle activity in a sample of skeletal Class II, Division 1 malocclusions, electromyographic and cephalometric analyses were undertaken in a sample of twenty adolescent children. For each subject, electromyographic activity was recorded from the left anterior temporal, masseter, and orbicularis oris muscles at rest, in maximum intercuspation, and during clenching. In addition, mandibular displacement was measured simultaneously with a kinesiograph, and twenty-seven anatomic points were digitized from a lateral head film. A computer-based system was used to sample the data and to determine correlation coefficients between selected parameters. Five significant correlations were found (at the 99 percent confidence level) for the rest position data. High anterior temporal amplitude was correlated with flat palatal planes and large ramus heights; high masseter amplitude correlated with upright maxillary incisors. Anterior positions of the mandible at rest correlated with flat occlusal planes and small pogonions. In contrast, significant correlation coefficients could not be identified for the maximum intercuspation recordings. However, low orbicularis oris muscle amplitude during clenching was correlated with high lower face height, overerupted mandibular molars, and elongated maxillary incisors. This interdependence of jaw muscle activity and craniofacial morphology in Class II, Division 1 subjects suggests a contribution from the musculature to the development of the dentition.

Cephalometry↗

Treatment of finger ischemia with Bier block reserpine.

Fourteen patients with severe Raynaud symptoms, including four patients with ulceration of the fingers, were treated by regional medical sympathectomy achieved by the tourniquet controlled intravenous injection of reserpine. Nine of the patients had significant objective clinical improvement which, in each patient, correlated with the demonstration of vasospasm on pretreatment studies. The five patients without improvement had advanced organic obstructive arterial disease without vasospasm.

Adult↗

Lower-extremity amputations for ischemia.

During the past eight years, we performed 312 lower-extremity amputations for ischemia. Amputation requiring no prosthesis was achieved in 31% of patients, knee joint preservation in 72%, and overall primary amputation healing in 75%. Amputation mortality was 6%. The use of prior arterial reconstruction, careful wound care, and willingness to accept nonhealing of trial amputations were important factors in obtaining the most distal possible healed amputation. An accurate evaluation of the impact of new methods of selecting amputation level and evaluating amputation results can only be achieved by a report of the total institutional amputation experience, not by reports of a single type of amputation.

Aged↗

Precise diagnosis of aortic anastomotic aneurysm by computed tomographic scan.

False aneurysms that involve aortoprosthetic anastomoses may be difficult to diagnose prior to fatal rupture. We report a case in which a false aneurysm that developed six year after aortofemoral-graft insertion was accurately diagnosed by a computed tomographic (CT) scan after both ultrasonography and angiography had failed to make the diagnosis. The ability of CT scanning to demonstrate anastomotic aneurysms and accurately determine the presence of periaortic hemorrhage is discussed.

Aged↗

Extended profundaplasty. Indications and techniques with results of 46 procedures.

We performed extended profundaplasty 46 times in 36 patients. Twelve procedures were performed for ischemic ulcers, 23 for ischemic rest pain and 10 for short-distance claudication. Fourteen procedures were performed independently, 21 to provide outflow for proximal bypass grafts, and 11 were combined with distal bypass grafts. Four of the 46 procedures failed; the rest have been successful for limb salvage or relief of symptoms at a mean follow-up of 15 months. Technical points emphasized are autogenous patch closure of the entire endarterectomy site and careful attention to end-point detail. The results demonstrate that this procedure provides durable limb revascularization.

Aged↗

Percutaneous angiographic embolization: a procedure of increasing usefulness: review of a decade of experience.

During the past decade percutaneous therapeutic vascular occlusion was performed on 152 occasions in 124 patients. The primary indication for vasoocclusive therapy was acute or recurrent bleeding. Upper gastrointestinal bleeding from arterial sources was controlled in 92 percent of patients and acute variceal bleeding in 83 percent. Renal embolization was performed for palliation of severe pain and hematuria from unresectable renal primary or secondary malignancies, to decrease blood loss and facilitate surgery in operable renal tumors, and for ablation of renal function to control chronic protein loss or severe hypertension. Our encouraging experience convinces us that transcatheter embolization is a useful, safe and effective procedure in selected patients. It seems certain that the technique of therapeutic embolization will be improved, its indications extended and its application become commonplace whenever angiographic skills and facilities exist.

Angiography↗

Finger gangrene caused by small artery occlusive disease.

Available evidence indicates that about one third of all patients presenting with localized finger gangrene developed the condition due to intrinsic occlusions of the small arteries of the hand and fingers caused by one of a variety of systemic diseases. We have treated 35 such patients in the past seven years. A variety of diagnostic tests allowed the establishment of the diagnosis of connective tissue disease in 14 patients, hypersensitivity angiitis in 13 patients, arteriosclerosis in five patients, and myeloid metaplasia, calciphylaxis, and carcinoma in one patient each. Treatment with cold and tobacco avoidance, vasodilators, and local debridement produced good results without amputation in 30 patients. Five patients required partial phalangeal amputation. These results suggest that appropriate diagnostic tests will allow an accurate diagnosis in all patients, and that the natural history is that of spontaneous improvement without major tissue loss. In our experience, surgical sympathectomy plays no role in the treatment of these patients.

Adolescent↗

Characterization of fragment E from fibrinogen and cross-linked fibrin.

Fragment E, a terminal plasmin digestion product of fibrinogen or fibrin, contains portions of the alpha, beta, and gamma chains linked by disulfide bonds. In this study, Fragment E from fibrinogen and fully cross-linked fibrin were purified by gel filtration of the soluble fraction from heated plasmin digests of either fibrinogen or fibrin or by step-wise chromatography of terminal plasmin digests of fibrinogen or cross-linked fibrin on DEAE-cellulose. Fibrinogen Fragment E and fibrin Fragment E migrated as single bands with identical mobilities on sodium dodecyl sulfate-polyacrylamide gel electrophoresis or on polyacrylamide gel electrophoresis at pH 3.2 or pH 8.6. After reduction by beta-mercaptoethanol, the two Fragment E species had very similar patterns on sodium dodecyl sulfate gel electrophoresis; each contained three subunits which had molecular weights ranging from 5,000 to 12,000. Only the subunit polypeptide derived from the gamma chain in either Fragment E contained carbohydrate. The two Fragment E species had identical sedimentation coefficients and identical molecular weights by equilibrium ultracentrifugation. The amino acid compositions were indistinguishable. Partial NH2-terminal sequence analyses of fibrinogen Fragment E and fibrin E were identical, indicating that plasmin had cleaved the NH2-terminal regions of the Aalpha or alpha and Bbeta or beta chains of both Fragment E Species.

Amino Acid Sequence↗