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Biomedical subjects

L M Silverstone

Publications and source records attributed to L M Silverstone.

At least 37 records · Page 2Linked to original sources
PubMed1983

In vitro caries-like lesion formation in F-containing tooth enamel.

In vitro caries-like lesion formation in F-containing tooth enamel (shark) showed a lower depth of penetration compared to that in human enamel (42 vs. 100%). After longer periods of exposure, the depth of penetration in shark enamel is only 33% relative to that in human enamel. The extent of dissolution in acetate buffer for powdered human enamel and for synthetic F-free calcium-carbonated-apatites was greater than for powdered shark enamel and for synthetic F-containing apatites. These results suggest that the cariostatic action of fluoride may be explained in terms of a combination of two effects: (a) the stabilizing effect against acid dissolution (caries) when fluoride is incorporated in the tooth mineral (apatite), and (b) a greater degree of remineralization (repair) in the presence of F solution.

Animals↗
PubMed1982

The effect of fluoride in the remineralization of enamel caries and caries-like lesions in vitro.

Remineralization occurs naturally during the formation of a carious lesion in human dental enamel and is seen in the form of two of the four classical histological zones of the lesion. Exposure of small lesions to a synthetic calcifying in vitro results in a significant increase in remineralization of the lesion. The degree of remineralization achieved depends upon the presence of fluoride ions in the calcifying fluid and its degree of supersaturation. It appears that only low levels of fluoride are required to trigger the mechanism of remineralization; raising the fluoride level further does not result in a greater degree of remineralization. The calcium ion concentration of the calcifying fluid is critical with respect to determining which components are supersaturated and which in turn determines the degree of remineralization achieved. With levels of 3.0 mM calcium only the superficial region of the lesion is remineralized whereas with a calcium concentration of 1.0 mM, remineralization occurs in depth. It is hoped that studies on remineralization phenomena will provide further insight into the mechanisms of caries formation and be the basis for a more powerful and effective form of caries prevention.

Calcium↗