Cardiac rhythm during nocturnal sleep in patients after several years of artificial respiration and hypo- and adynamia.
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Heart Rate↗
Biomedical subjects
L M Popova
Publications and source records attributed to L M Popova.
[Course of apallic syndrome after clinical death during anesthesia].
Anesthesiological errors after clinical death during narcosis for strumectomy are considered. These errors were continuation of surgery after systole, inadequate management of the systemic arterial pressure and cerebral circulation after global ischemia, early switch-off of artificial ventilation of the lungs. All these steps led to prolonged coma, development of the apallic syndrome, and invalidism of the patient.
Adult↗
[Activation of free-radical processes as a factor of ionizing radiation-induced changes in contractile activity of a vascular wall].
The influence of ionizing irradiation (1, 2 and 4 Gy 137Cs) on both the activity of free-radical processes in plasma, formed elements and aorta wall as well as on the character of contractile vascular reactions of isolated rings of thoracic aorta and carotid artery in rabbits has been studied. The experiments were carried out on the 7th day after the whole-body irradiation. The results indicate that simultaneously with the weakening of antioxidant mechanisms both endothelium-dependent and endothelium-independent vascular wall relaxation slightly decreases after 1 Gy exposure. Noradrenaline and KCI-induced contraction is shown to increase. However, these changes are not statistically significant. Irradiation in dose of 2 and 4 Gy considerably decreases endothelium-dependent relaxation. Nitroglycerin-induced relaxation greatly diminishes, KCI- and noradrenaline-induced constriction considerably increases in these conditions. The level of activation of free-radical processes considerably increases too. Thus, already on the 7th day after irradiation significant changes in reactivity of vascular wall are developed. Radiation injures both endothelium and vascular smooth muscle cells. The free-radical processes seem to be the main cause of radiation vascular damage, so there is a pronounced correlation between the changes of vascular contractile properties and the degree of activation of these processes.
Animals↗
[Prolonged artificial ventilation of the lungs in nervous system diseases].
Artificial ventilation of the lungs (AVL) has been carried out for many years in 25 patients with nervous diseases. Spontaneous respiration ceased because of peripheral neuron involvement in malignant myasthenia (5 cases), chronic polyneuropathy (1), paralysis of motor muscles after poliomyelitis (1), amyotrophic lateral sclerosis (11), spinopontocerebellar atrophy (1), and because of the central neuron involvement in 5 patients, 3 of these with the apnea syndrome during sleeping caused by syringobulbomyelia, atrophic process in the cerebellum and stem, and Arnold-Chiari's syndrome, and 2 with an extensive infarction in the pons (deefferentiation or locked-in syndrome). AVL was the longest in patients with paralysis of the motor muscles following acute poliomyelitis (23 years) and with amyotrophic lateral sclerosis (about 14 years). Prolonged AVL is possible in malignant myasthenia, but it may be discontinued during obligatory specific treatment. Specific features of many-year AVL, somatic functions and metabolic disorders associated with it are described.
Adolescent↗
[Respiratory insufficiency in adults with diphtheric polyneuropathy].
Twenty-five adult patients with grave diphtheric polyneuropathy after toxic diphtheria were followed up. Two symptom complexes of neurologic disorders leading to the development of peripheral respiratory failure of different severity were distinguished: 1) predominating glossopharyngeal paralysis and 2) combination of glossopharyngeal paralysis with grave generalized sensorimotor polyneuropathy (with pareses and paralyses of the respiratory muscles). The major quantitative parameters of pulmonary functions associated with various manifestations of respiratory failure are characterized. The significance of information on the type of dysfunction of vocal cords is emphasized. A high efficacy of a complex of respiratory reanimation used in the treatment of patients with peripheral respiratory failure is demonstrated.
Adult↗
[Intensive care in myasthenic and cholinergic crises].
Presents the epidemiology, possible etiology, and pathogenesis of myasthenia, methods of diagnosis of the disease, and clinical picture of critical states. Describes the present-day methods of treating myasthenic and cholinergic crises: programmed plasmapheresis combined with hormone therapy, pulsed therapy with superhigh doses of corticosteroids, and the most novel method for the treatment of autoimmune diseases, intravenous infusions of immunoglobulins. Draws attention to indications for artificial ventilation of the lungs and tracheostomy. Enumerates the drugs which are not recommended for patients with myasthenia. Emphasizes that the use of the whole complex of modern therapeutic methods for the treatment of grave myasthenia helps reduce the mortality to virtually null.
Adolescent↗
[Prognostic significance of neurophysiological parameters in nontraumatic apallic syndrome].
The time course of neurophysiological parameters (EEG, evoked potentials of various modalities, including P300, and polysomnography) was followed up in 10 patients with apallic syndrome (AS) of nontraumatic origin (heart arrest, stroke, neuroinfection, etc.) during the formation of the syndrome and the condition of various severity: incomplete formation of AS eventuating in gross psychoneurological defects and complete formation of AS (a stable vegetative state). A dynamic follow-up of not only EEG of awaken and sleeping patients, but of their evoked potentials, specifically somatosensory and P300, were shown to be significant for assessment of the course of AS and prediction of its outcome.
Adult↗
[Development of neuroresuscitation].
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Airway Obstruction↗
[Respiratory insufficiency in amyotrophic lateral sclerosis and methods of treatment].
Respiratory failure in amyotrophic lateral sclerosis is caused by paralysis and paresis of the respiratory and glossopharyngeolaryngeal muscles obstructing and restricting ventilation of the lungs. Examination of the external respiratory function helps early diagnose the condition. Monitoring of vital capacity of the lungs and respiratory rate is the most informative method. Analyzing the problem of progressive respiratory failure, we cannot neglect its ethical, social, and financial aspects. Informed consent of patients, families, and sponsors to prolonged forced ventilation of the lungs is to be obtained before the condition progresses to critical.
Amyotrophic Lateral Sclerosis↗