Biomedical subjects
Publications and source records attributed to L M Joseph.
Ultrastructural features of the Medlar body, the tissue form of cutaneous chromomycosis, are reported. Striking variability in such features reflects the interaction between fungi and host defense mechanisms.
Explore the source record for details and available documents.
The sensitivity of two strains of rat to the hypertensinogenic action of DOC was studied. Hypertensive cardiovascular disease was evident within 3 weeks of implantation of DOC pellets in sensitized female rats of the Sprague-Dawley and Long-Evans strains. Cardiac and renal hypertrophy due to DOC treatment was evident in both strains of rat. The DOC treatment also resulted in a significant decrease in absolute adrenal weight. These results, which indicate that Long-Evans rats are not resistant to DOC-induced hypertension, contrast with previous reports by others. An explanation of the discrepancy may be the use of free DOC rather than DOC acetate in the present study.