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Biomedical subjects

L M Freeman

Publications and source records attributed to L M Freeman.

At least 109 records · Page 6Linked to original sources
PubMed1977

A simple approach to the diagnosis of bronchopleural fistula.

The authors describe a simple, yet reliable technique for confirmation of a bronchopleural fistula. It is based on detection of radioactivity in the pleural space after the washout phase of the 133Xe ventilation study. This method demonstrated the pathological communication while bronchoscopy, bronchography, and methylene blue testing did not.

Bronchial Fistula↗
PubMed1976

The role of radionuclide imaging in disease of the alimentary tract.

The current status of radionuclide imaging studies of the liver, spleen, and pancreas is reviewed. Although current instrumentation and radiopharmaceuticals allow considerably better images than in the past, the overall accuracy of detecting liver metastases remains at 80%. The specificity of detecting hepatic space occupying disease has been enhanced by additional radionuclide studies which reveal the vascular and metabolic properties of the lesion.--The frequency of spleen imaging has increased since 99mTc-labeled colloids have been used. In most instances, it is obtained as a coincidental portion of the liver scintigraphic examination although it has significant primary indications such as in the elucidation of masses in or trauma to the left upper quadrant of the abdomen.--Selenium-75 selenomethionine pancreatic scintigraphy is best performed with serial Anger Camera images. Interfering hepatic activity is best removed by electronic subtraction techniques; if available. Careful attention to patient selection for the procedure is important. The mean true-positive and negative rates are 86% and 20%, respectively.

Humans↗
PubMed1976

Radionuclide venography of the lower extremities and inferior vena cava by continuous injection and moving bed gamma camera technique.

Radionuclide venography has proved to be a tedious procedure because of the need for multiple imaging set-ups with coordinated, repeated injections of radionuclide. The use of a moving bed gamma camera has shortened the procedure. This method enables the entire sapheno-femoral-iliac-caval system to be visualized in continuity on a single film. The moving table top system also adequately imaged the suspected areas of thrombi or endothelial damage on the post-exercise study on a single film.

Humans↗
PubMed1976

Localization of myocardial disorders other than infarction with 99mTc-labeled phosphate agents.

Myocardial studies with 99mTc-labeled phosphate agents were obtained in 20 patients without demonstrable cardiovascular disease, 24 patients with unstable arteriosclerotic heart disease (ASHD) without acute infarction, and six patients with myocardiopathy. The patients without cardiovascular disease showed no localization or tracer; the patients with unstable ASHD and without acute infarction showed nonfocal ill-defined accumulation of tracer; and the patients with myocardiopathy showed diffuse accummulation of tracer throughout the confines of an enlarged cardiac outline. Careful evaluation of both the distribution and intensity of the activity, in conjunction with the clinical picture, allows differentiation among these disease processes. Since ischemic areas around infarcted tissue may show increased activity, the value of this technique for sizing acute myocardial infarction may be limited.

Adult↗
PubMed1975

Pulmonary arteriovenous malformation: scintigraphic demonstration and analysis.

Scintiphotographic demonstration of a pulmonary arteriovenous malformation in an 8-year-old child is presented. Using a data processor, the transit of radiopertechnetate through the lesion as well as various portions of the lung is shown. The "steal" of blood flow from the left lobe is documented.

Arteriovenous Malformations↗
PubMed1975

Multinuclide evaluation of hepatic mass lesions.

Radionuclide imaging with labeled colloids is widely used to evaluate and localize primary and metastatic tumors of the liver. The method is fairly sensitive, but the nonspecificity of focal defects remains a significant limitation. Lesions such as cysts and abscesses appear as space occupying areas that are indistinguishable from neoplastic masses. Utilizing a variety of radiopharmaceuticals, one may obtain additional information concerning such lesions. Hepatic blood flow scintiphotography is performed with the Anger camera following the intravenous injection of a high activity, small volume bolus of 99m-Tc pertechnetate. Vascular lesions such as hepatomas or hemangiomas will show increased activity in the lesion which should easily differentiate them from avascular processes such as abscesses, cirrhotic pseudomasses and most metastatic lesions, all of which remain "cold" on these flow studies. If one does not posses a camera, useful blood pool rectilinear scans of these lesions may be obtained with 131-I or 99m-Tc human serum albumin or ionic 113m-In. Additional information concerning the metabolic activity of focal defects on the colloid study is obtained using 75-Se-selenomethionine or 67-Ga. The former is an indicator of active protein metabolism while the latter attaches to lysozymes of metabolically active cells. With either agent, hepatomas show avid uptake, metastatic lesions show variable uptake, and cysts or chronic pseudotumors of cirrhosis show poor uptake. The two agents differ in abscess detection where 75-Se-selenomethionine uptake is poor while 67-Ga concentration generally is intense. 131-I-Rose Bengal occasionally may prove useful in demonstrating impression by an atypically positioned gallbladder or focal dilatation of the biliary tract as a cause of a defect on the colloid scan. Ultrasound examination may complement the radionuclide studies. It is useful for corroborating the presence of lesions and for evaluating their consistency (cystic vs. solid). The information obtained from this multinuclide approach has made scintigraphy examination of the livermore specific. After the completion of this non-invasive series of studies, one generally may venture an intelligent opinion concerning the etiology of the space occupying disease.

Aneurysm↗