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Biomedical subjects

L M Crawford

Publications and source records attributed to L M Crawford.

At least 19 recordsLinked to original sources
PubMed1995

First DVM degrees.

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Education, Veterinary↗
PubMed1995

Delaney reform.

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Animals↗
PubMed1980

Regulation of animal care and research. The final order on Good Laboratory Practices.

On June 20, 1979, the Food and Drug Administration (FDA) enacted all aspects of its Good Laboratory Practices (GLP) program. The program was instituted to ensure the quality and integrity of the safety data submitted to FDA in support of the approval of regulated products, including human and animal drugs, food additives, biologicals, radiation-emitting products and human medical devices. Moreover, these considerations include all safety data submitted to support applications for research and marketing permits. These steps were taken in response to the appalling circumstances uncovered in a limited series of inspections of laboratories that was performed during 1975. FDA found careless experimentation, improperly trained employees, unreviewed data, omitted data, improper laboratory and animal care procedures and improperly monitored contract studies, including the failure of sponsors to validate the data appearing in the final study reports. The Congress responded to this situation by allocating FDA 600 new positions and .$16 million to remedy the problems that were evident. In their final form, the GLP's represent regulations fine tuned to assure proper safety testing with a minimum of increased cost. It is hoped that these regulations will increase public confidence in FDA decision making and will help to ensure that safe products are approved for marketing.

Laboratories↗
PubMed1977

The role of the thoracic compression reflex in the Heimlich Maneuver.

Using the dog as an experimental model, the relationship of the Thoracic Compression Reflex (TCR) to the Heimlich Maneuver (HM) was examined. TCR was equally effective as lateral chest compression in relieving artificially induced choke. Destruction of the TCR by vagotomy rendered relief of choke by HM ineffectual in 5 of 8 dogs. It was concluded TCR may be a factor in HM, but that mechanical compression of the lungs is also involved.

Airway Obstruction↗
PubMed1977

Hypocalcemic effect of aminoglycoside antibiotics in the dairy cow.

The effect of the parenteral administration of aminoglycoside antibiotics on the blood calcium concentration in dairy cows was investigated. Gentamicin was tested in vitro in blood drawn from cows, dihydrostreptomycin was tested in nonlactating cows and neomycin was tested in postpartum cows. The total and bound calcium fractions were significantly reduced by all three antibiotics. No change occurred in the unbound calcium fractions. Caution is advised in the use of these drugs in postpartum cows, especially those with a history of milk fever.

Aminoglycosides↗