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Biomedical subjects

L M Cobb

Publications and source records attributed to L M Cobb.

67 records · Page 4Linked to original sources
PubMed1972

Metastatic spread of human tumour implanted into thymectomized, antithymocyte serum treated hamsters.

The growth and metastatic spread of human tumours in immunosuppressed hamsters is described. A variety of human tumours were transplanted to the flank or the cheek pouch of the hamsters. Immunosuppression was obtained by combined thymectomy and ATS treatment. In the period up to 4 months after implantation, metastases to the lungs were observed with carcinomata of breast, colon, larynx and kidney; also melanoma, rhabdomyosarcoma, fibrosarcoma and teratoma of testis. Fourteen of 20 different tumours implanted metastasized to the lungs. Only 2 tumours, a hypernephroma and a melanoma, became established at the site of implantation; the remainder regressed even though the tumour was proliferating in the lungs.

Adenocarcinoma↗
PubMed1970

Radiation-induced osteosarcoma in the rat as a model for osteosarcoma in man.

A technique is described for the local induction of osteosarcoma in the rat by implanting (32)P-impregnated polyvinyl chloride discs into the distal femoral metaphysis. The incidence of osteosarcomata after 18 months was 28%. A comparison is made of the pathology of the radiation-induced osteosarcoma in the rat and the "spontaneous" osteosarcoma in man. The possible value of the rat osteosarcoma model is discussed.

Animals↗
PubMedDate not supplied

Effects in the rat of inhaling PVC dust at the nuisance dust level (10 mg/m3).

Rats inhaled a paste polymer polyvinyl chloride dust at an aerosol concentration of 10 mg/m3 for 6 hr/day, 5 days/wk for a 15-wk period. A small number of randomly scattered lung lesions were detected at 15 wk; these lesions were also present 15 wk after exposure to polyvinyl chloride had ceased. Few if any biochemical changes were detected at the alveolar surface in lung tissues or other organs of polyvinyl chloride-exposed rats. It is therefore concluded that at "nuisance" dust level this form of polyvinyl chloride polymer exhibits a weak biological reactivity.

Aerosols↗
PubMedDate not supplied

Early postoperative nutritional support using the serosal tunnel jejunostomy.

A silicone rubber serosal tunnel jejunostomy for postoperative nutritional therapy was placed in 38 patients who had major operations. A dilute, chemically defined diet was begun within 48 hours of surgery and an attempt made to advance it slowly to full strength by the fifth day. No catheter-related complications occurred. Intravenous fluid therapy was shortened to less than three days in 11 (29%) patients. Only 17 (45%) patients tolerated full-strength feedings within the protocol time. Three (8%) patients depended on their tube feedings for over 30 days and the need for parenteral nutrition was avoided. Of six septic patients, four had complete intolerance of the diet; two of these developed massive gastric hypersecretion. Serum albumin was a statistically significant indicator of whether a patient could tolerate tube feedings. No patient with an albumin less than 3 g/dl tolerated full-strength feedings and the pded. Of six septic patients, four had complete intolerance of the diet; two of these developed massive gastric hypersecretion. Serum albumin was a statistically significant indicator of whether a patient could tolerate tube feedings. No patient with an albumin less than 3 g/dl tolerated full-strength feedings and the patients with albumin greater than 4 g/dl had no problems. Postoperative feeding utilizing the serosal tunnel jejunostomy is technically safe, but feeding difficulties can be anticipated in those patients who are septic or severely malnourished; these are the patients whose nutritional needs are the greatest. The greatest benefits accrue to those patients who are in need of long-term nutritional support. We recommend routine placement of these catheters in major operations.

Enteral Nutrition↗