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Biomedical subjects

L M Abbey

Publications and source records attributed to L M Abbey.

At least 37 records · Page 2Linked to original sources
PubMed1984

Incidence of second primary breast cancer among patients with a first primary salivary gland tumor.

A survey was conducted through the Virginia Tumor Registry to ascertain whether there was a higher-than-expected rate of second primary breast cancers among women having a first primary tumor (benign or malignant) of the salivary glands. The population included 372 patients (182 men and 190 women) diagnosed between January 1, 1960 and December 31, 1979. Second primary breast cancer occurrence among women in this group was 4.8 times the expected number (P = 0.0102). Ages of those developing a second primary fell between 37 and 79 years. No racial prevalence was observed. The time of diagnosis of the first and second primary tumors was more than 6 years in 75% of the cases. It was concluded that women in our population incurred a fourfold-to-fivefold increased risk of a second primary breast cancer subsequent to the first primary salivary gland tumor. Consideration of this observation should be in the minds of clinicians seeing patients for follow-up.

Adolescent↗
PubMed1984

Prolactin binding in normal human minor salivary gland tissue: an immunohistochemical study.

The breast and salivary gland exhibit some similarities in the biochemical and cellular spheres. There are also some tumors that are common to both organs. The protein hormone prolactin seems to play a role in the health and disease of the mammary gland, and an investigation was launched to see if this hormone exhibited any binding activity in normal human minor salivary gland. With the use of immunohistochemical methods, dose-dependent staining for prolactin binding was demonstrated in the striated and collecting ducts in four of six specimens of normal human minor salivary gland (two males and two females). The hormone concentrations used ranged from 6.25 ng/ml to 500 ng/ml of highly purified rat prolactin. A review of known functions of prolactin in man and other animals is presented, and it was concluded that normal human minor salivary gland tissue possesses binding sites for prolactin, which suggests that prolactin may play a role in the metabolic functioning of the salivary duct cells.

Animals↗
PubMed1984

Focal oral warty dyskeratoma.

A 49-year-old white man developed focal oral warty dyskeratoma, which is a solitary, elevated nodule with a keratotic umbilicated center. The term "focal oral warty dyskeratoma" was suggested to distinguish these lesions from the histologically similar oral lesions found in Darier's disease. This paper reviews previously published reports of the lesion and presents an additional case. The average age of patients was 52.2 years, and a slight male predilection was noted. In almost all cases, the lesion was found in tissue overlying bone, with the maxillary alveolar ridge and palate being the most common locations. When the side of involvement was given, all lesions were noted to be on the left side. No evidence of a viral presence was seen with light or electron microscopic study, but the possibility of chronic irritation, such as tobacco usage, exists as an etiologic agent.

Darier Disease↗
PubMed1980

The clinical and histopathologic features of a series of 464 oral squamous cell papillomas.

A clinical and histopathologic analysis of 464 oral squamous cell papillomas is presented. Data on age, sex, race, location, clinical appearance, duration, recurrence, and clinical diagnosis are reviewed. One hundred seventy-six of the 464 specimens were examined for hyperkeratosis, character and amount of inflammatory infiltrate, and evidence of cellular atypia. The trends seen in this study support claims made by previous authors regarding incidence and inflammatory involvement. The data support a slightly higher occurrence rate in males than in females and in white as opposed to black patients. Papillomas were most abundant on the palatal complex, dorsum and lateral tongue borders, and lower lips, respectively. Confusion of papilloma for fibroma in the clinical diagnosis was less common than expected. Recurrence rate and incidence of multiple papillomas were low. Histologic study revealed a tendency for hyperkeratotic lesions to arise from nonkeratinized oral sites. Cellular atypia was found, but it is still unclear whether these changes are preneoplastic or due to an increased growth rate.

Adolescent↗
PubMed1978

Oral squamous acanthoma. Two additional cases with comments on etiology.

Two new cases of squamous acanthoma are presented, and the their clinical characteristics are compared to the eight cases previously reported. These two additional examples of this lesion are clinically similar to those previously reported. However, one of the two cases exhibits resolution after the removal of sources of trauma, thus lending support to the previously proposed theory of traumatic etiology.

Adult↗
PubMed1978

Preliminary study of changes in blood pressure associated with clenching in normotensive and hypertensive subjects.

This study was undertaken to test the effect of static, empty-mouth clenching on blood pressure levels in normotensive and hypertensive subjects. Blood pressures were measured before, during, and after one minute of empth-mouth static (isometric) clenching in 41 normotensive (group A) and 22 hypertensive subjects (group C). An additional group of 13 normotensive subjects (group B) were examined for elevations in blood pressure before, during, and after 30 seconds of clenching. Subjects in group A showed a clenching-related increase in mean arterial blood pressure of 5.5 mm Hg (P less than .001); in group C, there was an increase of 4.6 mm Hg (P less than .001); and in group B, there was an increase of 3.2 mm Hg (P less than .05). The results emphasize the relationship between isolated dental treatment and systemic health.

Adult↗
PubMed1976

A resurvey of hypertensive patients detected in a dental office screening program.

In order to ascertain the fate of hypertensive patients who were discovered through the Medical College of Virginia School of Dentistry Hypertension Screening Program, a telephone survey was conducted whereby the first 128 patients discovered to be hypertensive through the program were interviewed concerning their current state of care. All 128 patients were at least three months postreferral. Patients were asked whether or not they were still under a physician's care; those responding positively were further questioned regarding medications prescribed, medication consumption, and frequency of physician visits. In all, 109 patients were contacted. The 109 patients consisted of 18 patients treated at the hypertension clinic at Medical College of Virginia and 91 patients being treated by private physicians. Of the 18 clinic patients contacted, 17 (94 percent) were still being treated. Of the patients being treated by private physicians 62 (68.1 percent) were still being followed. Of the 109 patients contacted, 79 (72.5 percent) were still under care and 30 (27.5 percent) were no longer under care. Of the patients still under care 56 (71 percent) had been prescribed medicine and only two had discontinued medication. Forty-one patients saw their physician more frequently than every three months; 21 saw their physician every three to four months and 17 saw their physician semiannually or annually. Of the delinquent hypertensives in this study, 72 percent were still under care at the time of survey and of the previously undetected hypertensives 73 percent were still under care. It is concluded that there is still a significant drop-out-rate among hypertensives after refereral and that some void exists in the follow-up of hypertensives. The suggestion is made that the dentist may be able to assist in follow-up and possibly reduce the drop-out-rate.

Dentists↗
PubMed1976

Hypertension screening among dental patients.

Between January 1974 and March 1975, blood pressures were taken on all 2,222 dental patients admitted for treatment at the Virginia Commonwealth University, Medical College of Virginia School of Dentistry. According to the criteria of an elevated diastolic blood pressure (above 95 mm Hg) at three successive readings not less than five days apart, 131 patients were referred to physicians as suspected hypertensives. One hundred and thirteen patients were deemed hypertensive by their physician. A positive family history of hypertension was noted for 54% of the 113 undetected hypertensives. Of the 113 hypertensives, 6% visited their dentist yearly but did not visit their physician during the same time. On this basis we conclude that about 6% of dental patients can be expected to be referred to physicians as a result of high blood pressure screening in a dentist's office.

Adult↗
PubMed1976

A dental school hypertension screening program.

This paper has described a hypertension screening program at the Medical College of Virginia School of Dentistry. The program, which has been in operation for over two years, incorporates referral to a physician and a system of repeated follow-ups. The results indicate that the program has been successful in that 134 of a total of 141 patients with suspected hypertension have been successfully referred.

Blood Pressure↗