Search PubMed⌕ Search

Biomedical subjects

L Lundell

Publications and source records attributed to L Lundell.

At least 163 records · Page 9Linked to original sources
PubMed1983

Determination of fibrin-fibrinogen degradation products in gastric aspirate from patients with upper gastrointestinal haemorrhage.

During a 3-year period, 157 patients with upper gastrointestinal haemorrhage were admitted. In 54 of them gastric blood was made available for study of the level of fibrin-fibrinogen degradation products (FDP) to reveal the prevalence of increased local fibrinolytic activity. In all patients except three, FDP in systemic and gastric blood was identical, at less than or equal to 40 micrograms/ml. Two patients with erosive gastroduodenitis and one with a gastric ulcer had high levels of FDP in blood aspirated from the stomach. The present results would suggest that increased local fibrinolytic activity is very seldom involved in the induction and/or maintenance of upper gastrointestinal haemorrhage.

Blood Transfusion↗
PubMed1983

Infectious complications of the abdomen following gastric operations.

A retrospective study of postoperative abdominal infectious complications has been carried out for 625 consecutive patients operated upon for various gastroduodenal disorders during a ten year period; 14.7 per cent of the patients had a wound infection postoperatively and 6.6 per cent, an intra-abdominal abscess. In two-thirds of the patients with an abscess, a leakage was noted from an anastomosis. The patients who seemed to possess a particular risk of having septic complications postoperatively were those operated upon to control bleeding, patients having a second operation during the same hospital stay, patients operated upon for a recurrent ulcer and those operated upon for cancer. Furthermore, the type of operation performed, the age of the patient and some other patient related and hospital related factors, particularly coexisting hypoproteinemia or hypoalbuminemia, or both, seemed to influence adversely the infectious morbidity. The significance of these postoperative complications is also illustrated by the mortality figures and by the increased hospital stay brought about by these complications.

Abdomen↗
PubMed1983

Does preoperative treatment with cimetidine increase the risk of postoperative infection?

During a 5-year period, 145 patients were operated on for benign peptic ulcer disease. 105 patients did not receive cimetidine in the few weeks just before the operation, while 40 patients used it until the night before the operation. Although differing in size, the groups were comparable with regard to other relevant data. The cimetidine treated patients had more abdominal infectious complications postoperatively but this difference only reached statistical significance when patients who were operated upon for bleeding were excluded. Furthermore, patients on cimetidine suffered from significantly more pulmonary infections than those not having this preoperative drug regimen. These results indicate an unfavourable effect on the postoperative infectious morbidity of having a patient on cimetidine treatment in the weeks immediately preceding operation for peptic ulcer disease.

Adult↗
PubMed1983

Abdominal aortic aneurysm--results of treatment in nonspecialized units.

A retrospective study was made of the management of abdominal aortic aneurysms in eight district general hospitals in Sweden in the period 1971-1980. The numbers of admitted cases rose steadily during these ten years, as did the numbers of operations. Most of the patients had ruptured aneurysm, though there was a manifold rise in the number of operations for asymptomatic aneurysm. The postoperative mortality increased with the level of emergency presented by the aneurysm symptoms, and was about 80% in patients with clinical shock. The results of operative treatment were essentially stable during the study period and they appeared to be similar to those obtained in patients referred to units specializing in vascular surgery. Patient age, preoperative recognition of the diagnosis, concomitance of complicating disease and magnitude of peroperative blood loss seemed to influence the results of surgery. Postoperative deaths tended to occur in the first few days and to be independent of the volume of transfused blood, although severe bleeding was a significant and often fatal postoperative complication.

Aged↗
PubMed1981

Cholangiocarcinoma in a patient with biliary cysts.

A 15-year-old girl with multiple intra- and extrahepatic biliary cysts is presented. At a primary laparotomy a massive dilatation of the choledochal duct was found and a choledochocysto-duodenostomy was made. Initially the patient recovered but 1 1/2 years later a mass reappeared under the right costal arch. At a second laparotomy multiple neoplastic changes were found on the right and left liver lobes. Histologic examination of biopsies from the liver showed the picture of a cholangiocarcinoma.

Adenoma, Bile Duct↗
PubMed1981

Premalignant lesions of the periampullary region. Report of two cases.

Two patients with adenomatous lesions of the periampullary region of the duodenum are presented. In one patient the tumour was located in the most distal part of the common bile duct. The other patient had a tumour originating in the mucosa of the papilla of Vater and extending into the distal part of the common bile duct. The diagnostic and therapeutic problems with these lesions are discussed with respect to their precancerous nature.

Adenoma↗
PubMed1980

Wilkie's syndrome--a rarity?

Six cases are reported of vascular compression of the duodenum giving rise to duodenal and gastric dilatation, a condition which may be more common than generally recognized. The pathophysiology, difficulties of diagnosis and treatment are also discussed. Recognition of this disease is essential otherwise it may be fatal.

Adolescent↗
PubMed1980

Androgen metabolism in rat anterior pituitary cells in culture.

The metabolism in vitro of 4 androgens, namely testosterone, androstenedione, 5 alpha-dihydrotestosterone and 3 alpha-androstanediol has been studied in male and female rat anterior pituitary cells in primary culture. When testosterone was used as precursor, androstenedione, 5 alpha-dihydrotestosterone and 3 alpha-androstanediol were the main metabolites whereas androstendione was mainly converted into testosterone, 5 alpha-androstanedione, 5 alpha-dihydrotestosterone and androsterone. Studies on the metabolism of 5 alpha-dihydrotestosterone and 3 alpha-androstanediol showed that these compounds were easily interconverted and were also significantly metabolized to 5 alpha-androstanedione and androsterone. No aromatized compounds could be detected suggesting that androgen action in the pituitary cell occurs directly via the androgen receptor rather than through prior conversion into estrogens.

Androgens↗
PubMed1980

Osteogenic sarcoma of the breast. Report of a case.

The clinical, mammographical, cytological and histological features of a mammary osteogenic sarcoma are reported. The tumor, which was removed by only local excision, had suddenly appeared in the same breast from which previously an intraductal papilloma had been removed. Nearly three years after the operation there is no indication of recurrence.

Aged↗
PubMed1980

Clinical and laboratory findings in patients subjected to laparotomy for suspected acute appendicitis.

In a retrospective study, clinical and laboratory findings in 454 patients subjected to laparotomy for suspected acute appendicitis were evaluated. A normal appendix was found in 25% of the total series and was twice as common in female as in male patients. Perforated appendicitis was present in 8% of the series, most commonly in the youngest (less than 5 years) and the oldest (greater than 40 years) age groups. The incidence of severe appendicitis increased with the duration of the preoperative abdominal symptoms. Of the patients with a 'laboratory profile' including fever and leukocytosis, 44% had gangrenous or perferated appendicitis. Of those who additionally had elevated ESR (greater than 20 mm), 62% showed a gangernous or perforated appendicitis. The overall incidence of wound infection was 13.9%. Wound infection was closely related to the state of the appendix. The results thus indicated that patient's age, duration of abdominal symptoms and the 'laboratory profile' are important parameters for assessment of clinically suspected acute appendicitis.

Acute Disease↗
PubMed1980

Gastrocolic fistula: a rare complication of benign gastric ulcer.

Gastrocolic fistula secondary to a benign gastric ulcer is an extreme rarity. We recently treated a 81-year-old female with an en-bloc resection of the fistula tract combined with truncal vagotomi and pyloroplasty. The symptoms typical of a gastrocolic fistula, the diagnostic procedures and treatment are discussed.

Aged↗
PubMed1979

Skeletal scintigraphy in the inital assessment of women with breast cancer.

The results of 99mTc bone scanning have been retrospectively analyzed on 467 women admitted with a newly diagnosed breast cancer. The outcome of skeletal scintigraphy has been studied with reference to various prognostic variables. 9.8% of the women exhibited a positive scintigram. We could not find any influence of the tumour position on the frequency of positive bone scans. Age in relation to the menopause affected the rate of positive scans in that about three times as many positive scans were recorded in post menopausal women than in those who had not reached the menopause. Clinical staging according to the TNM system as well as the histological status of the axillary nodes correlated well with the rate of scintigrams that indicated a disseminated cancer disease. The tumour size, as measured in the operation specimen, strongly affected the frequency of positive and suspicious scans in accord with the prognostic significance of this parameter. The role of skeletal scintigraphy for an adequate staging of breast cancer patients is discussed.

Adult↗
PubMed1977

The value of thermography and the determination of fibrin-fibrinogen degradation products in the diagnosis of deep venous thrombosis.

Fifty-one patients with leg symptoms indicating deep venous thrombosis (DVT) were investigated concomitantly with thermography and phlebography. Altogether 26 legs with phlebographically proven DVT exhibited a thermographic picture typical of DVT. So, however, did 3 out of 25 legs with no DVT. A 94 percent agreement was found between phlebography and thermography when applied to legs with suspect DVT. The serum levels of fibrin-fibrinogen degradation products (FDP) were assayed in 58 patients attending hospital for suspect DVT. These patients were free from other diseases known to be followed by raised FDP levels. With borderline significance, the DVT group had higher FDP values. The usefulness of this laboratory test in the diagnosis of DVT is, however, questioned.

Adult↗