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Biomedical subjects

L Lumeng

Publications and source records attributed to L Lumeng.

236 records · Page 14Linked to original sources
PubMedDate not supplied

Alcohol preference and voluntary alcohol intakes of inbred rat strains and the National Institutes of Health heterogeneous stock of rats.

The alcohol preference ratios and the daily free-choice ethanol intakes (10% ethanol versus water) of the newly constituted National Institutes of Health (NIH) heterogeneous stock (N/Nih) rats, and of the eight inbred strains from which N/Nih derived, were measured. Among the eight inbred strains, ACI/N, WKY/N, F344/N, BUF/N, BN/Ssn, WN/N, M520/N, and MR/N, the ACI exhibited the lowest preference and intakes and the MR and the M520 the highest. The mean values for the N/Nih animals were intermediate among those of the inbred strains. The range of intake for the N/Nih rats was 0.06-9.5 g/kg of body weight/day, indicating that they should serve as an appropriate foundation in selection studies for alcohol-drinking preference.

Alcohol Drinking↗
PubMedDate not supplied

Effects of ethanol on monoamine and amino acid release from cerebral cortical slices of the alcohol-preferring P line of rats.

The effects of 250 mg/100 ml ethanol on the efflux of 3,4-dihydroxyphenylacetic acid (DOPAC) and the 35 mM K+-stimulated, Ca2+-dependent release of norepinephrine (NE), dopamine (DA), serotonin (5-HT), gamma-aminobutyric acid (GABA), glutamate, and aspartate from cerebral cortical slices of the alcohol-preferring P line of rats and stock Wistar rats were studied. The K+-stimulated, Ca2+-dependent release of GABA for the P rats was 35% lower, while the release of glutamate was almost twice that of the stock animals. The release of the other compounds was similar for the two groups. Addition of 250 mg/100 ml ethanol to the superfusion media did not alter the release of NE, DA, and 5-HT nor the efflux of DOPAC from cortical slices of either group of rats. However, the K+-stimulated, Ca2+-dependent release of GABA, glutamate, and aspartate was significantly enhanced by ethanol for both the P and stock group of rats. These in vitro data do not support a direct action of ethanol on DA, NE, and 5-HT release or on DOPAC efflux, but suggest a direct action on the transmitter release process for GABA, glutamate, and aspartate in the cerebral cortex.

Alcohol Drinking↗