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Biomedical subjects

L Little

Publications and source records attributed to L Little.

33 records · Page 2Linked to original sources
PubMed1982

A study of highly purified mucolipidosis III urinary N-acetyl-beta-D-hexosaminidase B.

Highly purified N-acetyl-beta-D-hexosaminidase B from normal urine and urine of a patient with mucolipidosis III was used to determine whether it has undergone any of the alterations associated with this genetic defect. Examination by sodium dodecyl sulphate/polyacrylamide gel electrophoresis showed that both the enzyme preparations contained protein components with apparent Mr values of 55 000 and 28 000. No differences in the binding and apparent KI (50%) to concanavalin A of the normal and mucolipidosis III enzymes were detected. However, the patient's N-acetyl-beta-D-hexosaminidase B had a slightly greater affinity for the lectin from Ricinus communis than did the normal enzyme. Two-dimensional tryptic peptide maps of the corresponding normal and the patient's N-acetyl-beta-D-hexosaminidase B subunits showed considerable homology. These results indicate that N-acetyl-beta-D-hexosaminidase b does not undergo the significant carbohydrate alterations characteristic of other acid hydrolases in mucolipidosis III.

Concanavalin A↗
PubMed1975

Dietary survey of low-income, rural families in Iowa and North Carolina. I. Research procedures.

Methods used in assessing the dietary intake of selected low-income, rural families are described. The sample consisted of 668 families randomly selected from predetermined locations in Iowa and North Carolina. A 24-hr. recall method supplemented with food models was used in gathering data on family food intake. The nutritional "adequacy" of the family diets was then evaluated according to family composition and the 1968 Recommended Dietary Allowances. The adequacy of individual nutrients was also evaluated by the same criteria. Nutrients studied included: protein, calcium, iron, vitamin A, ascorbic acid, thiamin, and riboflavin. The selection of the method in relation to opinions of previous investigators is discussed.

Ascorbic Acid↗
PubMedDate not supplied

Manual lymph drainage (MLD).

Treatment review is intended to inform and update nurses about treatments relevant to HIV/AIDS. Information presented in this column does not imply endorsement by ANAC. Additionally, the reader is advised that there is a paucity of scientific data to validate the effectiveness of manual lymph drainage.

Drainage↗
PubMedDate not supplied

Critical issues in the care of pregnant women with eating disorders and the impact on their children.

Pregnancy and eating disorders is a subject that has received relatively little attention in the literature. Nevertheless, serious complications have been found in both the mother and the baby during both pregnancy and post partum period. This article alerts practitioners to the physical and psychological risks that imperil pregnant women with histories of recent eating disorders, describes the experiences of three women with eating disorders during pregnancy whose children developed eating difficulties, and suggests some guidelines for the screening and care of women with eating disorders and their babies.

Adult↗
PubMedDate not supplied

The misunderstood child: the child with a nonverbal learning disorder.

ISSUES AND PURPOSE: To introduce nurses to the characteristics of nonverbal learning disorders (NLD) and their psychosocial trajectory in children. Despite the prevalence of learning disorders in children, few nursing professionals are familiar with NLD and their manifestations. CONCLUSIONS: The child with NLD faces unique challenges in the social, academic, visual-spatial, motoric, and emotional spheres. PRACTICE IMPLICATIONS: Nurses can play a vital role in the identification, education, and provision of resources for these children.

Adolescent↗
PubMedDate not supplied

All lines are open.

Explore the source record for details and available documents.

Adolescent↗
PubMedDate not supplied

Plasma lipids, lipoproteins, and mammographic densities.

There is strong evidence that the risk of breast cancer in populations is influenced by environmental factors. Plasma lipids and lipoproteins are known to be under environmental control and to have epidemiological and/or biological characteristics that suggest they may be relevant to breast cancer risk. The purpose of the study described here was to determine whether plasma lipids, lipoproteins, and the urinary excretion of the mutagen malondialdehyde (MDA) are associated with differences in breast cancer risk. We measured plasma lipids, lipoproteins, and urinary MDA in women without breast cancer but with different degrees of density of the breast parenchyma on mammography, a strong risk factor for breast cancer. Mammograms from 273 premenopausal women were digitized to high spatial resolution by a scanning densitometer, and images were analyzed to quantify the extent of density. The percentage of the breast occupied by mammographic densities was found, after controlling for the effects of age and the Quetelet index of obesity, to be significantly associated with plasma levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, apoprotein B, and urinary excretion of MDA. A multivariate model comprised of the Quetelet index of obesity, alcohol consumption, apoprotein B, parity, daily MDA excretion, and the skinfold thickness sum accounted for 36% of the variation in breast density. These results suggest that differences in lipid metabolism are associated with differences in breast cancer risk as defined by mammographic densities. These findings are consistent with several other observations that show a relationship between plasma lipids, lipoproteins, and risk factors for breast cancer.

Adult↗