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Biomedical subjects

L Lisá

Publications and source records attributed to L Lisá.

At least 19 recordsLinked to original sources
PubMed1992

[A non-classic form of congenital adrenal hyperplasia].

The authors examined five children with the non-classical form of adrenal hyperplasia. The clinical symptoms of the disease comprise: early congenital pubic hair, small stature, accelerated bone maturation, infertility, in girls hirsutism, acne, menstrual disorders, amenorrhoea, in boys oligospermia, acne. Laboratory examination reveals slightly elevated 17-OH progesterone values during the synactene loading test. It is an autosomal recessively hereditary disease. It is due to an allelic variant of the gene for 21 hydroxylase. The authors revealed a link with antigen B14. Even in the small group examined antigen B14 was present in 40%, although the prevalence in our population is 2.9%.

Adolescent↗
PubMed1992

A case of hyperplasia of the anterior lobe of the pituitary imitating intrasellar expansion.

The authors describe the case of an obese girl with severe hypothyroidism which led to increased TSH secretion and finally to hyperplasia of the anterior lobe of the pituitary diagnosed by magnetic resonance. After substitution treatment with thyroid hormones was started, marked improvement of the general condition, loss of body weight and normalization of laboratory findings and regression of hyperplastic tissue occurred.

Child↗
PubMed1992

[Juvenile granulosa cell tumor with subsequent occurrence of gastrointestinal polyposis, subcutaneous lipomatosis and nodular goiter].

A juvenile tumour from granulosa cells (M-8622/1), 13 x 8 x 6 cm, in the right ovary in a three-month-old girl produced some symptoms of pseudopubertas praecox isosexualis which disappeared after operation. Microscopic examination of the tumour revealed in addition to typical structures a less common differentiation to Sertoli cells. Despite actinotherapy and chemotherapy one and a half years after the onset of the disease X-ray examination revealed metastases in the lungs which were successfully cured by further doses of the above two types of treatment. Between the age of 6 and 15 years the girl developed successively polyposis of the stomach, small and large intestine (M-7564/0), subcutaneous lipomatosis of the trunk and left lower extremity (M-8881/0) and nodular goitre (M-7164/0), predominantly quiescent. In the literature a connection between gonadal stromal ovarian tumours and mesenchymal tumours, intestinal polyposis and disorders of the thyroid gland is described, but in different patients. The authors' observation is unique by the successive incidence of these changes in a single patient surviving 15 years after operation; and thus genetically conditioned associations could be involved.

Adolescent↗
PubMed1991

Comparative response of Pisum sativum nodulated with indigenous soil Rhizobium populations and/or co-inoculated with a Rhizobium leguminosarum strain. I. Acetylene-reducing, dihydrogen- and carbon dioxide-evolving activities.

No significant differences in the acetylene-reducing activity and evolution of H2 and CO2 from nodulated roots of Pisum sativum inoculated with soil Rhizobium populations from two soils with different acidities (Ruzynĕ soil 7.6; Lukavec soil 4.9) were observed. Rhizobium population from Lukavec soil formed nodules, exhibiting a higher H2 evolution. Co-inoculation with the Hup+ strain 128C30 (7 x 10(7) cells per seedling) eliminated, to some extent, the effect of soil populations on physiological activity.

Acetylene↗
PubMed1991

[Growth disorders].

In growth disorders it is important to consider carefully all causes which may lead to growth retardation. Therefore possible factors and diagnostic possibilities are listed. The importance of the prognosis of the affected child is emphasized.

Child↗
PubMed1990

[Abnormal placement of the testes].

The authors defined a uniform classification of abnormal positions of the testes. They recommend also a uniform therapeutic procedure: after the first year of life treatment with human chorionic gonadotropin in one or two curves, if orchiopexy fails.

Cryptorchidism↗
PubMed1990

[Gonadal dysgenesis].

The authors describe six patients, female phenotype with karyotype 45X/46XY. Two girls suffered from pure gonadal dysgenesis, four from mixed gonadal dysgenesis. The authors emphasize the intact axis hypothalamus-pituitary gonads. In the above diagnoses the authors recommend revision and extirpation of the gonads with regard to possible malignant growth in the dysgenetic gonad.

Adolescent↗
PubMed1990

[Osteocalcin].

Explore the source record for details and available documents.

Adolescent↗
PubMed1990

[Use of steroid indicators in monitoring the treatment of congenital adrenal hyperplasia].

The authors divided forty children and adolescents with inborn adrenal hyperplasia caused by a block of 21-hydroxylase of steroids (CAH) according to clinical criteria into adequately and inadequately treated. Substitution treatment with hydrocortisone or hydrocortisone combined with fludrocortisone was administered three times a day in individual doses. In order to find an adequate indicator of the adequacy of therapy, the authors assessed in addition to total urinary 17-oxosteroids also 17 alpha-hydroxyprogesterone, androstenedione and 11 beta-hydroxyandrostenedione in serum. The values of urinary 17-oxosteroids did not correspond to the clinical condition of the children; in younger children three was a high percentage of falsely positive and in older children of falsely negative results. As to serum steroids, the most suitable indicator for monitoring was 17-hydroxyprogesterone. The authors consider its levels above 30 nmol/l as a basis for consideration of raising therapeutic doses, while levels below 2.2 nmol/l signalize possible overdosage of the drug. Concurrently elevated levels of 17-hydroxyprogesterone and androstenedione are found in particularly inadequately treated children. 11 beta-hydroxyandrostenedione is not a useful indicator for monitoring of CAH treatment. In any case it is necessary, when controlling CAH therapy, to select an individual procedure and to evaluate results in the context with the patient's clinical condition.

17-Ketosteroids↗
PubMed1989

[Somatic development in a group of 59 children with congenital adrenal hyperplasia in relation to therapy].

The authors followed up 59 children with congenital adrenal hyperplasia. They compared the somatic development of these children in the group treated with hydrocortisone only and in the group treated with fludrocortisone. They evaluated their growth, bone maturity, sexual maturing. The results of the clinical investigation are in favour of combined therapy.

Adrenal Hyperplasia, Congenital↗
PubMed1989

[Problems in evaluating obesity in childhood].

For screening of obese children and marginal obesities the authors elaborated tables for boys and girls aged 6 to 18 years. The tables are based on height and body weight of the Czechoslovak population examined in 1985.

Adolescent↗