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Biomedical subjects

L Lindberg

Publications and source records attributed to L Lindberg.

At least 55 records · Page 3Linked to original sources
PubMed1990

Demonstration of blood-vessellike structures in cartilaginous callus by antilaminin and antiheparin sulfate proteoglycan antibodies.

The vascularization of the callus of experimental nonfixated tibia fractures in rat was investigated with antibodies against two basement-membrane macromolecules, i.e., laminin and the heparin sulfate, low-buoyant-density proteoglycan. The purpose of the investigation was to study the relationship between the appearance of blood vessels and the development of cartilaginous callus. The ages of the callus were three, five, eight, and 11 days after the fracture, that is, from before the cartilage was demonstrable on Day 5 until the enchondral bone formation started on Day 11. The abundant blood vessels in the differentiating granulation tissue, in the periosteal callus, and in the cortical bone itself were stained, as were the endomysia of the surrounding myofibrils. During the whole course, the cartilaginous callus also contained vessellike structures stained by the antibodies. These structures are apparently nonfunctioning vessels. Also, some of the chondrocytes were stained by antilaminin. This study implies that cartilage is not formed as a result of insufficient blood supply, but rather as a natural link in a predetermined course of the migrating mesenchymal cells.

Animals↗
PubMed1988

Effects of calcium antagonists on myogenic and neurogenic control of resistance and capacitance vessels in cat skeletal muscle.

The effects of five different calcium antagonists (diltiazem, felodipine, nifedipine, nimodipine, and verapamil) on cat skeletal muscle resistance and capacitance vessels were studied in a whole organ preparation. These calcium antagonists seemed to have the similar qualitative effects on these vascular functions. Calcium antagonists were found to be potent inhibitors of myogenic vascular reactivity (here defined as the maximal increase in flow resistance evoked by a sudden rise of transmural pressure). Basal vascular tone and vascular tone induced by low frequency stimulation of sympathetic nerves were both less sensitive to these drugs than vascular tone induced by myogenic vascular reactivity. Sympathetically mediated vascular tone at high stimulation frequencies seemed to be least sensitive. Further, resistance vessels were much more sensitive to these drugs than capacitance vessels. Finally, basal tone in the large bore arterioles were more sensitive than in the small bore arterioles, a surprising finding which was interpreted with the aid of computer simulations using a mathematical model of local vascular control in cat skeletal muscle. The model suggested that this difference could be due to a delicate interaction between myogenic vascular reactivity and metabolic vascular control. It is suggested that the inhibition of myogenic vascular reactivity is a factor contributing to the edema formation of calcium antagonists.

Animals↗
PubMed1985

Radiographic loosening after revision with gentamicin-containing cement for deep infection in total hip arthroplasties.

Seventy-two infected total hip arthroplasties were revised with cement containing gentamicin and were followed up with regular radiograms for periods of up to six years. The infection healed in 61 cases and persisted in 11. An analysis of the radiographic changes in regard to the signs of loosening showed that about half of the cases with a healed infection had a minimal demarcation between bone and cement. In about one-third of the patients, a radiolucent zone of up to 2 mm in thickness developed during the first one to two years and then seemed to remain stable. In the other cases, a progressive resorption, indicating true loosening, was observed. All the cases with remaining infection (except one patient who died of heart disease) exhibited progressively increasing resorption zones. Progress, however, was possibly slowed by the effects of the gentamicin cement and the systemic antibiotic treatment.

Aged↗
PubMed1983

Aseptic loosening of hip prostheses. A histologic and enzyme histochemical study.

Twenty-one total hip arthroplasties were revised because of aseptic loosening. The bone and soft tissue membrane bordering the cement in a total of 37 biopsies from the acetabulum and femur were studied histologically and by enzyme histochemistry. The soft tissue membrane was infiltrated with macrophages and had high acid phosphatase activity. Other inflammatory cells were rare or absent. Concomitant bone formation and bone resorption were usually present at the bone-soft tissue border. The bone generally consisted of viable, remodeled lamellar bone. The host bone seemed to have been resorbed by a soft tissue front moving outward from the cement. Reactive new bone formation began at the bone-soft tissue border and appeared to constrain the resorptive process. Articular wear seemed to play no part in initiating the loosening process. The role of bone cement in this respect is obscure, because there were no obvious local signs of cytotoxicity. These observations support the theory of mechanical instability as the primary cause of the tissue reaction.

Acetabulum↗
PubMed1983

Total hip joint arthroplasty with gentamicin-impregnated cement. A clinical study of gentamicin excretion kinetics.

The excretion pharmacokinetics of gentamicin (GM) following total hip joint arthroplasty with GM-impregnated bone cement were studied in ten patients. The patients received 0.5-1.1 g of GM. Twenty-four-hour portions of urine were collected for up to 60 days after operation. GM concentrations in urine were initially 8-25 mg/l, and during the first four days the excretion ranged from 0.7 to 25 mg/day. On the 30th day drug levels in the urine were 0.5-1.0 mg/l, and the excretion was 0.5-1.0 mg/day. The GM excretion-time curve consisted of an initial rapid phase that terminated four to six days after operation, with a half-life of 0.65 days, and a slow phase with a half-life of 7.5-73.0 days (mean, 16 days). From the area under the excretion-time curve and from extrapolation of the registered terminal phase, it was calculated that 5%-18% (mean, 13%) of the GM administered was accounted for. Thus, a major portion of the drug was unaccounted for. Data obtained two years after operation suggested that the half-life of the terminal phase is much longer (greater than 240 days) than that calculated from data obtained during the first two months after operation. It was calculated that the surface area of the cement would be in excess of 150 cm2 and that the volume of an interface tissue layer 1 mm thick would be approximately 15 cm3. Thus, at three weeks, when the daily excretion was approximately 1 mg/24 hours, 67 micrograms/cm3/day of GM would be available for antimicrobial action at a tissue--cement interface 1 mm thick.

Adult↗
PubMed1981

Systemic antibiotics and gentamicin-containing bone cement in the prophylaxis of postoperative infections in total hip arthroplasty.

In a prospective controlled multicenter study, the prophylactic effect of gentamicin-containing bone cement on postoperative infections in total hip arthroplasties was compared with that of systemically given antibiotics; 812 arthroplasties were randomly assigned to an antibiotic and 821 to a gentamicin-cement group. When the patients had been followed for a period of one to two years, 13 deep infections were diagnosed in the antibiotic group and three in the gentamicin-cement group. The difference was statistically significant.

Anti-Bacterial Agents↗
PubMed1980

Differentiated care of hip fracture in the elderly. Mean hospital days and results of rehabilitation.

Two series of elderly patients with hip fracture were compared with regard to hospitalization time and social situation after discharge from hospital. Our series included 131 patients from 1966 with late weight-bearing and 362 patients from 1972--1973, mobilized with early weight-bearing. Approximately two-thirds of the patients came from their own homes and one-third from institutions. The mean hospital stay for patients discharged to their own homes was 7 weeks in 1966 and 3--4 weeks in 1972--1973. This decrease in hospitalization time did not cause any increase in the proportion of patients discharged to institutions. Thus, among patients admitted from their own homes 48 per cent of the survivors returned directly home in 1966, and 62 per cent in 1972--1973. As compared to the prefracture mobility, postoperative mobility at 2 weeks proved to be a better indicator of the patient's chances of returing home. This may be a helpful guide when planning the aftercare of these patients.

Aftercare↗
PubMed1980

Function of fifty-seven septic, revised and healed total hip arthroplasties.

An evaluation of hip function was made 2-5 years postoperatively in 57 patients reoperated using gentamicin-containing bone cement because of deep infection after total hip arthroplasty. Forty patients were completely free from pain and 17 had slight intermittent pain. Fifty-one had normal or nearly normal walking ability. Most patients managed dressing and getting in and out of a bath without help. It is concluded that revision in most case offers a satisfactory solution for the patient and gives a better functional result than simple removal of the prosthesis.

Aged↗
PubMed1979

Rehabilitation after hip fracture in the elderly.

Sixty-eight patients with hip fracture, mean age 79 years, from the city of Lund, were studied with special reference to functional and social rehabilitation at follow-up 1 year later. As compared with patients coming from institutions for permanent care, patients coming from their own homes had a significantly better prognosis in terms of survival, mobility and ability to cope with activities of daily living (ADL). However, patients returning home needed increased domestic help. Patients living with someone returned home sooner than those living alone. Although many of the patients who returned home could walk without support or with a walking-stick, more than one half did not go out shopping. More active measures, e.g. early home visits by a rehabilitation team, might give the patients more self-confidence and independence. Immediate weight-bearing did not appear to impair healing of the hip fracture or increase the risk of necrosis of the femoral head.

Activities of Daily Living↗