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Biomedical subjects

L Lin

Publications and source records attributed to L Lin.

437 records · Page 25Linked to original sources
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Bone fractures in children with chronic cholestasis.

The clinical features, biochemical data, roentgenographical bone changes and liver histological studies of four children with fractures related to chronic cholestasis are described. Two of them had Alagille syndrome and the other two, biliary atresia. Only one patient presented with forearm fracture associated with typical radiographic evidence of rickets. The others revealed generalized osteopenia together with fractures in arms, forearms, and wrists respectively. Of these, one with rickets had hypocalcemia and hypophosphatemia; one had decreased parathyroid hormone with mild hypocalcemia and hyperphosphatemia; one had hyperphosphatemia solely. Eucalcemia and euphosphatemia were noted in the remaining patient. Their bone lesions deteriorated in spite of treatment, except for the one with clinical rickets. All the patients succumbed eventually. It was concluded that the real pathogenesis of bone lesions in end-stage liver disease of chronic cholestatic children remains unclear. However, because rickets may intervene, continuing efforts to supply vitamin D and calcium since diagnosis of chronic cholestasis on a long-term basis, to prevent fracture, is still mandatory.

Child, Preschool↗
PubMedDate not supplied

Coefficient of accuracy and concordance correlation coefficient: new statistics for methods comparison.

A new statistic, the Coefficient of Accuracy, C(a), has been developed by Lin for methods comparison. When an old measurement method is compared to a new measurement method or if the same method is compared in two laboratories, the Coefficient of Determination, r2, is typically used to measure the relationship. However, r2 only measures the precision of the relationship. The newly developed statistic, C(a), measures the accuracy of the relationship. When these two statistics are combined together, they form a single statistic for both accuracy and precision called the Concordance Correlation Coefficient, rc.

Algorithms↗
PubMedDate not supplied

Construction of phosphorylatable monoclonal antibody CC49 with a casein kinase II recognition site.

A phosphorylation site for casein kinase II was introduced into chimeric monoclonal antibody CC49 (MAb-chCC49) by site-specific mutation of the coding sequence. The phosphorylation site for the casein kinase II was positioned at the carboxyl terminus of the heavy chain constant region of the MAb-chCC49. The resultant modified MAb-chCC49CKII was expressed in NS0 cells and purified. The MAb-chCC49CKII protein was phosphorylated by casein kinase II with [gamma-32P]ATP to high radiospecific activity. The 32P-labeled MAb-chCC49CKII binds to cells expressing TAG-72 antigens. The introduction of the phosphorylation sites for casein kinase II into monoclonal antibodies (MAb) provides a new reagent for the diagnosis and treatment of cancers. This demonstrates that the casein kinase II recognition site can also be used to introduce phosphorylation sites into proteins.

Amino Acid Sequence↗