2-Cyclohexen-1-one: toxicology and study of an occupational dermal exposure.
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Biomedical subjects
Publications and source records attributed to L Levin.
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The authors conducted a cross-sectional study to determine the prevalence of chronic noncancer pain or disability in first-degree relatives of patients who had sustained a physically traumatic injury with resultant chronic pain. A control group of general internal medicine patients was also interviewed about existence in their family of chronic pain or of disability, either pain-related or related to nonpainful chronic illness. None of the control patients were themselves experiencing acute or chronic pain. There was no statistically significant difference between the two groups in the prevalence of chronic pain or disability in family members. The study's findings suggest that chronic noncancer pain patients should not be viewed as a uniform group with regard to learned behaviors and/or familial aggregation.
Succinylcholine was injected intraoperatively in 41 strabismus patients with congenital esotropia or intermittent or constant exotropia. Regression analyses were performed to investigate the predictive relationships between the one-, six-, and 26-week postoperative alignment and the intraoperative, succinylcholine-induced ocular position. Ocular position, determined by the interlimbal distance in millimeters, was calculated using a semi-automated, video replay analysis system. Large, statistically significant correlation coefficients were obtained for patients undergoing bimedial recessions of 4.0 to 5.5 mm and bilateral lateral rectus recessions of 5.0 to 7.0 mm. Small correlations were obtained for esotropes undergoing the recession/resection procedure and those with bimedial recessions of 6.0 mm or greater. These data support the theory that the succinylcholine-sensitive subgroup of the extraocular muscle fibers are those whose tonic contracture provide the motor component to ocular alignment. Sample sizes at present are insufficient to suggest clinical use of these data. In future research, these relationships will be tested for their ability to predict postoperative alignment and thereby, improve success rates in strabismus surgery.