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L Lepsanović

Publications and source records attributed to L Lepsanović.

At least 19 recordsLinked to original sources
PubMed1996

[The metabolic syndrome and hyper-Lp(a)-lipoproteinemia in peripheral obliterative atherosclerosis: 2 case reports].

One of the characteristics of peripheral vascular disease in diabetic patients is that it occurs at the time of detection of diabetes mellitus. As one of the possible pathogenic mechanisms, in non-smokers, is the sol-called metabolic syndrome (obesity, disorders in regard to metabolism of lipids and carbohydrates and hypertension). Lipoprotein Lp(a) is the most atherogenic among lipoproteins. While data on coronary arterial disease exist, although contradictory, there is a small number of those which document the same for peripheral vascular occlusive disease in diabetics. Two patients, non-smokers, with characteristic constellation of risk factors, are described as possible models for further epidemiologic examinations.

Arteriosclerosis Obliterans↗
PubMed1995

[Serum lipids in surgical and natural postmenopause].

Values of serum lipids in women of different estrogenic status were analyzed in this paper. A deficit of estrogen was established in groups of surgically induced and natural postmenopausal women, but a relatively preserved production of estrogenic hormones in the group of women with preserved ovaries and group of premenopausal women. Serum triglycerides, the total serum cholesterol and LDL fraction of cholesterol were highest in surgically induced premenopausal women, somewhat lower in natural postmenopausal women, while they were statistically significantly lower in premenopausal women and women with preserved ovaries. Values of HDL cholesterol did not statistically significantly differ in certain groups of women. Index of atherosclerosis (IA) was highest in surgically induced postmenopausal women (3.18), somewhat lower in natural postmenopausal women (2.99) and premenopausal women (2.64), while it was statistically significantly lower in women with preserved ovaries (2.57).

Arteriosclerosis↗
PubMed1994

[Determination of lipoprotein Lp(a) in clinical practice: personal experience].

The paper presents up-to-date knowledge on structure, origin, metabolic ways and physiologic role of lipoprotein Lp(a). Apart from discussing analytic actions, plasmatic distribution and conjunction with atherosclerosis, results of our own investigations which took several years performed in about 5000 patients are being reported as well as directives for rational diagnostic and therapeutic approaches.

Arteriosclerosis↗
PubMed1993

[The role of ultrasonography in the diagnosis of enlarged parathyroid glands].

The ultrasonographic diagnosis of parathyroid glands was introduced by the Japanese in 1975. Only after more perfect machines have been introduced, first of all by advancement of "real-time" technique, this method started being used as a routine. The paper shows results of ultrasonographic investigation in 200 patients separated into two groups. In the first group 100 patients were examined with a clinical suspect of primary hyperparathyroidism from which in 30 the existence of parathyroid gland adenoma was diagnosed. Scintigraphy of parathyroid glands was performed in the smaller group of patients; the comparison of these two methods was done, and in 77.7% cases coincidence was found. In the group of 10 operated patients comparison of the two mentioned methods was carried out, with surgical or pathohistologic findings and the coincidence was complete. In the second group 100 patients were examined belonging to the chronical program of hemodialysis, from which in 24 cases existence of swollen parathyroid glands was found. Comparison of ultrasonographic and scintigraphic findings was also done and the coincidence was 68.75%. At the end, the importance of ultrasonography in the first diagnostic stage of swollen parathyroid glands was pointed out.

Adenoma↗
PubMed1993

Red blood cell deformability in diabetes mellitus: effect of phytomenadione.

Decreased deformability of red blood cells (RBC) in diabetes mellitus (DM) is considered to be linked to microcirculatory complications in this condition. As we found that phytomenadione increased RBC deformability in experimental animals, the question was raised, whether phytomenadione had the same effect on the RBC of diabetic patients. The study was performed in 10 patients with insulin-dependent diabetes mellitus, where the erythrocyte deformability was impaired. Patients received 10 mg/day phytomenadione i.m. for five days. Deformability was measured with policarbonate membranes (Nucleopore) with pore diameter 5 microns, under gravity. The results were expressed as the ratio (r) between the flow of 1.5 ml (r1) and 2 ml (r2) of RBC suspension and 1.5 ml of buffer. Phytomenadione increased the erythrocyte deformability in patients with diabetes mellitus, lowering the value r1 from 3.54 +/- 0.84 to 2.32 +/- 0.61 (p 0.02) and r2 from 7.80 +/- 2.41 to 4.65 +/- 1.07 (p 0.01). The values after treatment reached the range of healthy controls (r1 3.11 +/- 0.98, r2 6.52 +/- 3.04). The whole blood viscosity was significantly lowered after phytomenadione (5.28 +/- 0.58 mPas before, 4.64 +/- 0.74 mPas after, p < 0.02) with unchanged plasma viscosity, but significantly lowered internal viscosity of erythrocytes.

Adenosine Triphosphate↗
PubMed1992

[Hypophyseal pseudomacroadenoma in primary hypothyroidism--2 case reports].

Primary hypothyroidism is often accompanied with hyperprolactinemia and if the untreated disease persists longer hypophyseal adenoma consisting of thyreotropic cells might develop. On the other hand, although rarely, simultaneous occurrence of primary hypothyroidism and hypophyseal prolactin adenoma might be encountered. If substitutional therapy, after the establishment of euthyroid status, does not eliminate clinical signs of hyperprolactinemia and normalize prolactin levels, a decision can be made in favor of hyperprolactinemia within primary hypothyroidism. In that case possible tumor changes in the hypophysis will show regressive tendency towards final disappearance. However if clinical signs and hyperprolactinemia persist after the establishment of euthyroid status, especially if accompanied with compressive signs this should be regarded as a coincidence of primary hypothyroidism and hypophyseal prolactin tumor. We report two female patients with primary hypothyroidism and hypophyseal pseudomacroadenoma.

Adult↗
PubMed1992

[Psychological characteristics of obese persons with special reference to periods of modified fasting].

It is well known fact that the results of modified fasting can be improved if the basic therapeutic method is combined with psychotherapeutic procedures. We have analyzed the data taken by a poll from 55 extremely obese women treated by modified fasting regimen. The results absolutely justify the above mentioned remark that radical reduction cures may cause critical moments most frequently recognized in hunger crisis when patients feel a need for conversion with medical staff. With no doubt, any help from a qualified person might be perfectly beneficial. Besides, obese persons are more inclined to depressive moods which may aggravate during these cures. In order to maintain the achieved result for a longer period of time if not for good, a continuous team work which include psychotherapeutic measures is of special significance. On the highest level it would be smart to establish an association of treated obese people, which would be a link between a patient and a professional.

Adult↗
PubMed1992

[The metabolic X syndrome--4 case reports].

The study reviews current knowledge about metabolic X syndrome characterized by android obesity, arterial hypertension, insulin resistance with hyperinsulinemia and disturbed carbohydrate tolerance, a decrease of HDL cholesterol and an increase of the triglyceride rich VLDL particle level. The study describes 4 female patients having been diagnosed for this syndrome. Only an ontime and vigorous reduction of overweight, along with intensified physical activity can prevent later development of serious complications, first of all, in cardiovascular system.

Adult↗
PubMed1991

[The importance of intact parathyroid hormone determination in the evaluation of parathyroid gland function].

The study investigates the importance of determining the intact parathormone in the evaluation of parathyroid gland function in different conditions of change in their function and the alteration of parathormone metabolism: primary and secondary hyperparathyroidism, hypoparathyroidism and hyperthyroidism. The role and place of intact parathormone determination in routine diagnostic schemes of calcium homeostasis disorders was reviewed by the simultaneous determination of the indicators of calcium and bone metabolism and other calcium homeostasis hormone regulators, as well as the C- and N-terminal parathormone fragments and by establishing their mutual links with the values of the intact parathormone.

Humans↗
PubMed1990

[Case report of pheochromocytoma with an atypical localization].

One of the endocrine causes of arterial hypertension is pheochromocytoma, usually located in the adrenal gland medulla. Extra-adrenal tumor locations are seldom encountered, and this can considerably complicate the diagnostic procedure. If a distinct clinical manifestation exists, supported by the finding of elevated catecholamine values, it is essential to persistently and carefully search for the place of their increased production. Such an attitude is completely justified in regard to the knowledge that this endocrinologically conditioned hypertension can be permanently and successfully solved with a surgical procedure. A case of pheochromocytoma has been presented with an atypical mediastinal location, prolonged and complicated diagnostic procedure, which has been successfully solved by surgery.

Adult↗
PubMed1990

[The significance of the determination of apoproteins in the diagnosis of lipoprotein metabolism disorders].

The study, in the first place, describes the basic physical, chemical and biological characteristics of the most important apoprotein classes and their role in the metabolism of certain lipoprotein fractions. Special regard is given to the significance of determining particular apoproteins in the serum and in some lipoprotein fractions for the detection of particular disorders in lipoprotein metabolism.

Apoproteins↗
PubMed1990

[Drug therapy of obesity--results of treatment with dexfenfluramine].

The paper presents the results of treatment in 22 obese persons with hypoenergetical nutrition of 4200 kJ with the simultaneous application of dexfenfluoramine in the daily dose of 30 mg in the course of three months. During this period of time an average weight loss of 7.5 kg was achieved, and a loss of 10 kg and more in one third of the patients. The controlled laboratory parameters did not show any significant deviations, and side effects in the form of mouth dryness and diarrhea were rare, and of a lighter intensity so that they did not demand the stop of therapy. When correctly indicated, dexfenfluoramine presents a valuable supplement in the therapeutic arsenal for obesity treatment, because thanks to its anorexigenic effect it eases the conducting of hypoenergetical nutrition and improves the treatment effect of this pathological condition.

Adult↗
PubMed1989

[Significance of highly sensitive (immunoradiometry assay) TSH in the evaluation of hypothalamo-hypophyseal-thyroid axis function].

A diagnostic value of immunoradiometric TSH assay in the evaluation of the function of hypothalamo-hypophyseal-thyroid axis was investigated in this paper. Normal values of basal TSH and TSH response during TRH test were determined by the use of ROC analysis. It was found out that there was a highly significant correlation between basal TSH and the responses during TRH test and that the diagnostic value of basal TSH in the evaluation of function of thyroid axis was almost identical to the diagnostic value of responses during TRH test. This finding pointed to the fact that basal TSH determination could replace the application of TRH test in diagnostic of thyroid axis disturbances. Comparing diagnostic value of basal TSH with other tests which served for the confirmation of thyroid axis disturbances, this test proved to be dominant, the most specific and the most sensitive in respect to other applied tests and could be regarded as the first step in diagnostic scheme of thyroid disturbances.

Humans↗
PubMed1989

[Lipid peroxides and their importance in an organism].

The paper reviews recently obtained data on the origin and role of lipid peroxides and their secondary decomposed products in the organism. Polyunsaturated fatty acids are the basic substrate of lipid peroxidation caused either by the insufficiency of the defense mechanisms or by their influx exceeding the requirements of the organism. The increased formation of lipid peroxides is associated with a number of disorders, specially with the onset of atherosclerosis. Mechanisms which help lipid peroxides to influence the process of atheroma plaque formation with special regard to the role of oxidized LDL particles are discussed.

Animals↗
PubMed1989

[Multicenter study of the therapeutic efficiency of glycvidone (Beglynor)].

Results of the multicentric investigation of therapeutic efficacy of glycvidon were presented in this paper. The investigation was performed in 15 centres and comprised 768 patients with type 2 diabetes mellitus. A considerable improvement in metabolic regulation was attained which led to the reduction in glycemia level on an empty stomach and after the meal, to the reduction or elimination of glycosuria and to the significant decrease in glycolized hemoglobin. A parallel improvement in serum lipid levels was also registered. Tolerance of glycvidon was good and hypoglycemic incidents were very rare and as a rule of mild degree.

Adult↗