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Biomedical subjects

L Lemaître

Publications and source records attributed to L Lemaître.

15 recordsLinked to original sources

[Cricoid chondronecrosis after prolonged endotracheal intubation].

Subglottic area injuries after prolonged endotracheal intubation are relatively frequent but cricoid cartilage necrosis is rare, with uncertain prognosis. Endoscopic findings are evocative even when clinical signs are not. When suspected, CT scan is required. The CT appearance is not specific, but the diagnosis can be strongly suggested in cases of fragmentation and collapse of the cricoid cartilage. We report two cases of cricoid chondronecrosis.

Adult↗

[Imaging of upper urinary tract tumors].

Urothelial tumors of the upper urinary tract are mainly represented by transitional cell carcinomas. They are usually multifocal, synchronous or metachronous. Patients most often present with hematuria. Histological staging is according to the degree of cellular anaplasia (grade) as well as to the degree of wall invasion (stage). Accurate and differential diagnosis are by excretory urography (EU) and/or by computed tomography (CT) associated with EU. EU and endoscopic investigations assess tumoral extension. The most appropriate treatment is radical nephroureterectomy with a cuff of bladder. Early and high recurrence is common; therefore a regular follow-up is required and depends on the initial treatment and the tumoral aggressiveness. This follow-up is performed by imaging, endoscopic and cytologic investigations.

Aftercare↗

[Imaging of testicular tumors].

Testicular cancer is the most common malignancy in young men and its incidence is increasing. The overall rate of cure can exceed 90% when management is optimal. Ultrasonography for diagnosis and thoraco-abdominal CT for staging are the optimal imaging modalities. In this paper we analyze technical parameters as well as findings and the strategy of examinations in testicular neoplasm.

Adult↗

[Basic sonographic interpretation].

Basic sonographic semiology includes the dots and lines that are the basic constituants of ultrasound images and the different structures that are the sonographic representation of the different tissues (fluid, fat, calcifications and stones, air, parenchyma). Knowledge of these basic interpretative skills is mandatory to the clinical practice of sonography and allows understanding of the different sonographic manifestations of pathologic processes and identification of artifacts and pitfalls.

Child↗

[Upper urinary tract MRI].

New MRI modalities today available allow exploration of many kidney diseases. Main developments have been made in the diagnosis of small tumors and tumoral extension of huge masses. The other important way of application is MR urography which perfectly show the dilated urinary tract in few seconds. Their potential application are for renal insufficiency, allergic reaction to iodine contrast media and in cases of contra indication to ionised radiations. It is a complementary sequence to assess the urinary tract in pelvic exploration. The evaluation of kidney function will be possible in the near future.

Contraindications↗

[Primary large cell neuroendocrine carcinoma of the kidney: morphologic and immunohistochemical features of two cases].

Primary neuroendocrine carcinomas of the kidney are infrequent. The large cell neuroendocrine carcinoma is a subtype with an aggressive course and a worse prognosis. We report two cases, a 35-year-old man and a 75-year-old woman who died within 6 and 5-months after surgery despite radical nephrectomy and chemotherapy. Histological and immunohistochemical features are presented.

Adult↗

[Granulocytic sarcoma. Apropos of a case].

The authors report a case of orbital granulocytic sarcoma complicating a case of acute myeloblastic leukaemia, which was investigated by CT and MRI. CT revealed a moderately contrast-enhanced orbital mass. The MR signal intensity was identical to that of grey matter on T1-weighted sequences and identical to that of white matter on T2-weighted sequences.

Humans↗

[Value of x-ray computed tomography in assessing the extent of invasive lympho-epithelial thymoma in the adult. Therapeutic implications].

This study concerns 12 patients who were in hospital for the work-up and treatment of an invasive lympho-epithelial thymoma. The extent of the disease was studied by systemic computed tomographic (CT) scanning of the thorax and abdomen. Three patients out of nine examined presented initially with asymptomatic renal metastasis. Three patients were treated straight away by poly-chemotherapy; the nine others benefitted either from radiotherapy alone (four cases) or from radiotherapy associated with surgery (4 cases) or an isolated surgical exploration (1 case). CT examination was carried out in 11 patients 3 months after the beginning of treatment and 7 times clinically latent metastasis were rediscovered (renal, adrenal, hepatic, thyroid, cerebral and osseous). These 11 patients benefitted secondarily from polychemotherapy. The results confirm the gravity of the condition: only three patients are living and in complete remission with a follow up of 24 to 48 months. The frequency of latent metastasis, detected by CT scanning, during the course of a malignant thymoma justifies the systematic performance of this examination in the work up of the disease extent and therapeutic surveillance in these patients, and leads one to reconsider the place of chemotherapy in the therapeutic strategy of these tumours.

Adrenal Cortex Neoplasms↗

[Ultrasonic diagnosis of periventricular leukomalacia in premature infants].

The ultrasonographic study through the fontanelle of 192 children below 33 weeks of age and surviving after the neonatal period led to the diagnosis of leukomalacia by identifying anechogenic cavities in the periventricular area in 7 cases. Clinical pictures were not characteristic. Important electro-encephalographic changes were constantly found, even before the occurrence of sonographic signs. Although non specific they are still suggestive when associated hemorrhage is not present. With these criteria, diagnosis seems to be correlated with severe neurologic prognosis. Its interest and chronology warrant the extension of the ultrasonographic supervision of severely immature infants up to the end of the second month.

Brain Ischemia↗

[Risk of bone disease as a result of fluoride intake in chronic renal insufficiency].

Four cases of osteosclerosis were observed in patients with renal failure. All subjects presented with moderate reduction in renal function which had been stabilized for several years. Osteosclerosis appeared progressively but was clinically symptomatic in only one patient. Fluoride intoxication was ascertained on the basis of X-ray examination and bone biopsy. In addition, the source of fluoride intoxication was easily recognized as the drinking water (2 to 3 1/day), "Vichy Saint Yorre" commercial mineral water (fluoride concentration 9 mg/l) in 3 cases, and tap water in the fourth case. These observations emphasize the risk of high chronic fluoride intake in patients with renal failure, even with mild reduction of glomerular filtration rate.

Adult↗

[Cerebral abscesses disclosing pulmonary angioma. Rendu-Osler disease].

A 50-year old male patient presented with two successive cerebral abscesses over a 9-month period. Rendu-Osler-Weber disease was diagnosed on the basis of recurrent epistaxis and telangiectasis of the mucosae and skin. In addition, many members of the patient's family had a history of epistaxis and one had a cerebral angioma of unusual location. Our patient's chest was normal on physical and radiological examination, but pulmonary angiography disclosed a small angioma. Removal of the angioma prevented further cerebral infections. The prevalence of pulmonary arterio-venous fistulae in Rendu-Osler-Weber disease and their clinical manifestations (especially in the central nervous system) are reviewed, together with the value of family studies and the therapeutic approach.

Brain Abscess↗

[Treatment of type II familial hypercholesterolemia by portacaval anastomosis].

Termino-lateral porto-caval anastomosis seems at present to be the most effective treatment for severe familial hypercholesterolaemia. The mechanism by which it acts has not been determined and its long term results are not known. One success and one failure confirm the immediate action of anastomosis in a condition with a fatal prognosis.

Adolescent↗