Biomedical subjects
L Leibovici
Publications and source records attributed to L Leibovici.
Non-Hodgkin's lymphoma in the elderly: data at presentation.
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An outbreak of measles among young adults. Clinical and laboratory features in 461 patients.
We report the clinical and laboratory characteristics of measles infection in an unselected group of 461 young adults. Otitis media was diagnosed in 9.8%, sinusitis in 4.1%, pneumonia in 3.7%, and keratitis in 3.3% of the patients. Minor T-wave changes on electrocardiogram were observed in only 0.7% and jaundice in 0.4%. Elevated liver enzymes were found in 51% of the patients. Creatine kinase (CK) MM fraction was high in 44%. Traces of myoglobin were found in the urine of 14% of those with a high CK, and of the 13 patients with the higher CKs, 12 had an abnormal serum aldolase. We emphasize several points of interest in this large and unselected group of young adults. There was 1) possible evidence of rhabdomyolisis in some of our patients; 2) a lower rate of electrocardiogram abnormalities than previously reported; 3) no evident correlation between initial laboratory values and subsequent complications; and 4) lack of a clinical or laboratory difference between patients who had been vaccinated with an attenuated virus during childhood and those who had not.
Growth rate determines activity of porphobilinogen deaminase both in nonmalignant and malignant cell lines.
PBGD activity and growth rate were determined in cultures of rat embryo fibroblasts, nontransformed and MLV/MS transformed fibroblastic cell lines; NIH-3T3 cells, and in a mouse lymphosarcoma cell line [L-929]. The two parameters examined correlate positively (P less than 0.001). The results of this investigation would seem to indicate clearly that porphobilinogen deaminase activity is related to growth. However, these experiments do not rule out the possibility that malignant transformation per se also causes changes in porphobilinogen deaminase activity.
Non-cardiac use of nitroglycerin patches.
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Carcinoma of the prostate presenting as interstitial lung disease.
Two patients were hospitalized because of fever, cough and dyspnea and an interstitial infiltrate of both lungs that was shown to be a lymphangitic spread of prostate carcinoma. The presentation of prostatic carcinoma as interstitial lung disease is rare, and emphasizes the importance of rectal examination and determination of acid phosphatase in the context of interstitial lung disease.
Pseudomonas stutzeri causing late prosthetic valve endocarditis.
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Diagnosis of polymyalgia rheumatica and giant cell arteritis: a note of caution.
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Leukocytoclastic vasculitis in malignant lymphoma. Case report and review of the literature.
A 76-year-old patient presenting with leukocytoclastic vasculitis and later diagnosed as having diffuse immunoblastic lymphoma is presented. The clinical data of patients with leukocytoclastic vasculitis and lymphoproliferative disease reported in the literature are summarized. Other diseases associated with this form of vasculitis and the proposed pathogenesis are briefly discussed.
Urinary tract infections and sexual activity in young women.
A group of 147 young women with symptomatic urinary tract infection (UTI) were compared with a control group of 105 symptom-free young women belonging to the same population. On logistic-regression analysis, sexual activity was the only significant and independent behavioral difference between the groups (87% of women with UTI were sexually active vs 32.7% of the control group). Of the 147 episodes of UTI, only 28.9% occurred within 24 hours of sexual intercourse; of 24 episodes that occurred during follow-up, the percentage that occurred within 24 hours of intercourse was 33.3%. This finding is in discordance with the close temporal association between UTI and sexual intercourse reported in previous studies.
[Urinary tract infection in young women].
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Etiological and clinical characteristics of diarrhea in young adults, with special reference to shigella gastroenteritis.
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Nailfold capillary microscopy in essential mixed cryoglobulinemia: a report of several cases.
Nailfold capillaries were examined in eight patients with essential mixed cryoglobulinemia. Two patients disclosed marked abnormality. These patients had no Raynaud phenomenon. Four patients with Raynaud phenomenon disclosed normal capillary patterns. Thus, microvascular pathology in essential mixed cryoglobulinemia is not related to Raynaud phenomenon.
Changing resistance of uropathogens to antibiotics.
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Characteristics of urinary tract infection caused by coagulase-negative Staphylococcus in a group of young women.
Of 147 young women, aged 17 to 34 years, with signs, symptoms and bacteriological evidence of urinary tract infection (UTI), 23 (15.6%) had an infection caused by coagulase-negative Staphylococcus (coag- neg Staph). All patients with coag- neg Staph UTI were sexually active, in contrast to 84.7% of those with UTI of other causes (one-tailed P = 0.03). The former had a higher rate of vaginal discharge (60.9 vs. 25.8% in the latter group, P = 0.003), but fewer of them used tampons as menstrual protection or oral contraceptives. A high percentage of women with coag- neg Staph UTI had commenced sexual activity recently, as compared with the rest of the group (P = 0.03). In a stepwise logistic regression analysis, the only variables that were significantly associated with coag- neg Staph UTI were vaginal discharge and recent onset of sexual activity.
Single-dose treatment of urinary tract infection in young women: data indicating a high rate of recurrent infection during a short follow-up.
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Causes of diarrheal disease in soldiers stationed in Lebanon and in northern Israel.
A study of acute gastroenteritis in soldiers was carried out during a 1-year period. Causes of diarrhea were compared between 33 soldiers stationed in southern Lebanon and 174 soldiers stationed in northern Israel. Shigella sp. caused 42.4% of diarrheal disease in Lebanon, compared with only 19.0% of cases in Israel. Sh. flexneri was a more common cause of bacillary dysentery in Lebanon than in Israel (71.4 vs. 18.2%, respectively), and caused a more severe illness.
Alcohol-induced changes in urinary aminolevulinic acid and porphyrins: unrelated to liver disease.
Urinary porphyrins and their metabolites aminolevulinic acid (ALA) and porphobilinogen (PBG) were determined in 15 normal volunteers and in 45 alcoholics, subdivided into three groups according to their liver function tests and histology: alcoholics exhibiting no evidence of hepatocellular damage; alcoholics with fatty liver and impaired function of liver enzymes; and alcoholics with proven liver cirrhosis. The dominant trend observed in those alcoholics devoid of any evidence of liver disease was increased ALA, PBG, and uroporphyrin. Coproporphyrinuria was shared by the patients exhibiting liver damage. The data shown enabled us to differentiate between the direct, primary effect of alcohol on the heme biosynthetic pathway and the secondary indirect effect, which is probably related to liver damage that follows alcohol consumption. Evaluation of the results led to the suggestion that urinary ALA could possibly serve as a marker of alcoholism. The specificity and sensitivity of the test were found to be 87% and 80%, respectively.