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Biomedical subjects

L Laslett

Publications and source records attributed to L Laslett.

15 recordsLinked to original sources
PubMed1996

Evidence of myocardial injury during prolonged strenuous exercise.

These preliminary data suggest that extremely prolonged intense exercise may induce subclinical myocardial injury. Although questions of assay interference exist, the importance of this finding has prompted planning of a larger study using a methodologically more specific assay.

Biomarkers↗
PubMed1995

Balloon catheter retrieval of dislodged coronary artery stents: a novel technique.

Potential complications of intracoronary stenting include stent dislodgement and embolization. We describe a patient in whom a stent was dislodged from a coronary balloon catheter to the iliac artery. A peripheral angioplasty balloon was used to withdraw the stent into the arterial sheath and thereby remove it from the patient.

Aged↗
PubMed1995

Normal left main coronary artery diameter can be predicted from diameters of its branch vessels.

An uncommon though vexing problem exists when the left main coronary artery appears subjectively to be diffusely stenotic relative to its branch vessels, but the severity of such stenosis cannot be determined because of the lack of a normal reference. To overcome this problem, 20 coronary angiograms demonstrating no evidence of disease were quantitatively analyzed to determine the normal ratio of left main diameter to the sum of the diameters of its immediate branches. For bifurcating left mains, the mean ratio of diameter of left main to sum of diameters of its two immediate branches was 0.65 +/- 0.04; for trifurcating left mains, the mean ratio of diameter of left main to sum of diameters of its three immediate branches was 0.56 +/- 0.02. Thus, it appears feasible and practical to predict the normal diameter of the left main from the measured diameters of its immediate branches.

Arteries↗
PubMed1995

Unique spontaneous coronary artery dissection in an elderly woman.

Spontaneous coronary artery dissection is a rare condition, typically occurring in younger women. A 75-year-old woman with this condition, 17 years older than previously reported, is described, including her unusual presentation with angina rather than infarct. The 112 previously reported cases are summarized and treatment options discussed.

Age of Onset↗
PubMed1995

Predictors of the effect of heparin during cardiac catheterization.

This study was designed to determine if the activated partial thromboplastin time (aPTT) present at the end of a diagnostic cardiac catheterization was correlated with specific patient or procedure characteristics. No relationship between time from heparin bolus and the aPTT was found. Age, weight and body surface area were found to influence the aPTT at catheterization completion (p < 0.05). Patient sex, height, smoking status, hematocrit, and type and volume of contrast used were not correlated with aPTT at the end of catheterization. This suggests possible usefulness of the age and weight of patients to guide the dose of heparin used at cardiac catheterization.

Age Factors↗
PubMed1995

Hypertension. Preoperative assessment and perioperative management.

Hypertension is a frequently encountered abnormality in patients being prepared for surgical procedures. This condition complicates anesthetic and postoperative management, but careful monitoring and treatment allow hypertensive patients to tolerate surgery safely. Particular attention should be directed toward continuing antihypertensive medicine until the time of the surgical procedure or initiating treatment before it, monitoring the blood pressure frequently after the operation, and controlling postoperative hypertension with one of many parenteral agents available. The possibility of the presence of secondary hypertension and cardiovascular complications of hypertension should be considered during the preoperative assessment.

Humans↗
PubMed1988

Aerobic exercise training reduces resting and exertional blood pressure in cardiac patients.

We evaluated the effects of exercise training (ET) on resting and exertional blood pressure in patients with cardiac disease. ET consisted of 20 to 30 minutes of aerobic activity three times weekly for 12 months. The study group comprised 17 males and three females (mean age 58 years, range 40 to 71 years). Blood pressure was evaluated at rest and during exercise after 6 and 12 months ET. A training effect was documented by an increase in functional capacity from 7.5 METs (1 MET = 3.5 mL oxygen consumption/kg/min) pre-ET to 8.8 and 9.2 METs after 6 and 12 months, respectively. The following significant (P less than 0.05) effects occurred on blood pressure in association with ET: resting systolic pressure pre-ET decreased from 131 to 124 mm Hg at 12 months ET; submaximal (50% pre-ET maximum capacity) systolic and diastolic pressures decreased from 150/84 to 142/80 mm Hg (6 months ET) and 144/80 mm Hg (12 months ET); diastolic pressure at maximal exertion fell from 83 to 77 mm Hg (6 months ET) and 78 mm Hg (12 months ET). Systolic blood pressure at maximal exertion was not increased despite significant increases in peak workload achieved at 6 and 12 months ET. Therefore, ET not only enhances functional capacity in cardiac patients but may be associated with a beneficial cardiac effect through attenuation of both rest and exertional blood pressure.

Adult↗
PubMed1987

Exercise training in coronary artery disease.

Physical training using dynamic, nonisometric exercise can increase physical endurance and decrease cardiac work load of submaximal exertion. This is true for people with coronary artery disease and for normal individuals, and it may also be true for those with selected other cardiac diseases. Effective training should involve exercise at between 70 and 85 per cent of predicted maximal heart rate for 15 to 20 minutes or more at least three times a week. An exercise prescription should be written on the basis of individual patient needs and limitations and utilizing an exercise electrocardiogram test. Medically supervised exercise programs allow physical training for patients with heart disease to be conducted safely and efficiently. The effect of training in coronary disease patients is primarily attributable to increased efficiency of peripheral musculature and circulation; how much true cardiac adaptation results is variable. Training improves psychologic outlook, probably reduces selected risk factors for coronary disease, and may improve longevity.

Adrenergic beta-Antagonists↗
PubMed1987

Exercise and sudden death.

Sudden death during exercise is rare, but limited data suggest that vigorous physical activity is associated with an increased risk for this event, particularly in individuals with overt cardiac disease or a high coronary risk profile. The mechanism of exercise-associated sudden death is usually a lethal arrhythmia; however, this may vary depending on the underlying cardiovascular disease. In the great majority of cases, cardiovascular disease is present in persons who die during exercise. In young individuals (less than 35 years old) hypertrophic cardiomyopathy and congenital coronary anomalies are the most common conditions, whereas older victims usually have coronary artery disease. Cardiac disease is typically unrecognized prior to death in young persons; in the older population, most have overt coronary disease or recognizable coronary risk factors. Screening asymptomatic individuals to identify increased risk of a cardiac event during exercise presents major problems in terms of logistics, expense, and accuracy, but careful evaluation, including exercise testing, is mandatory before a program of increased activity in patients with overt cardiac disease. In other cases, the extent of any evaluation must be determined on an individual basis.

Adult↗
PubMed1983

Ventricular ectopy frequency and complexity not altered by exercise training in coronary disease patients.

To assess the effect of exercise training on ventricular ectopy in coronary artery disease patients, 21 patients with coronary disease had 24-hour ambulatory electrocardiograph recordings done at entry into a cardiac rehabilitation program and after 6 months' exercise training. Mean frequency of premature ventricular contractions was not significantly changed, being 9.7 +/- 33.0/h before and 13.2 +/- 94.3/h after training. 9 demonstrated an increased, 9 a decreased, and 3 an unchanged frequency. Lown grade of ventricular ectopy was similarly not consistently changed with training.

Arrhythmias, Cardiac↗