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Biomedical subjects

L Lareng

Publications and source records attributed to L Lareng.

At least 19 recordsLinked to original sources
PubMed1984

[Mediastinitis caused by odontogenic anaerobic bacteria].

Anaerobic odontogenic mediastinitis appeared to be on the increase. The case described had a favourable outcome. The aetiology and pathology of this disease, the dreadful prognosis of which was a mortality rate of 50%, were discussed. The aggravating factors appeared to be general, these patients presenting a particular predisposition, due to steroids and malnutrition, and anatomical, as the cellulitis spread along cervical fascial planes. The treatment always required was mediastinal surgical drainage by a transcervical approach or by thoracotomy, the association of three antibiotics (a penicillin with an imidazole, an aminoglycoside or a macrolide) and a high energy and nitrogen intake.

Adult↗
PubMed1984

Early cerebral prognosis of anoxic encephalopathy using brain energy metabolism.

Cerebral arteriovenous differences in oxygen content [C(a-v)O2] and glucose content [C(a-v)gluc] were used to predict outcome in 20 patients who remained comatose after resuscitation for cardiopulmonary arrest. Cerebral prognosis was good when C(a-v)O2 values were greater than 1.8 mMol/L and the oxygen glucose index (OGI) was greater than 85%. Our results suggest that cerebral recovery is linked with increased oxidation associated with the beginning of nonglycolytic metabolism.

Adolescent↗
PubMed1984

[Axillary block of the brachial plexus and flunitrazepam premedication in surgery of the upper limb (study of 1,500 cases)].

The authors report their experience of regional block using anaesthesia of the brachial plexus by the axillary approach. 1 500 axillary blocks have been done since 1976. They perfect their technology and report their results. Because of the innocuity of regional block and its simplicity, they use it in seventy per cent of superior limb acute or regular surgery.

Adolescent↗
PubMed1983

[Plasma fibronectin. Role in severe infections and intensive care].

Plasma fibronectin (pFN) levels were measured in 52 patients throughout their stay in an intensive care unit. At the same time a close watch was kept for signs of sepsis. Low pFN levels regularly accompanied--but did not precede--infectious episodes and were also found in patients without septic complications. These findings indicate that a fall in pFN does not constitute a factor of increased susceptibility to infection.

Adult↗
PubMed1983

[Peridural analgesia during labor: comparative study of a fentanyl-marcaine combination and marcaine alone].

A randomised trial was carried out to evaluate the use of a mixture of fentanyl with marcaine in epidural analgesia. Two series of 30 patients each were studied: in the first only marcaine was given for the epidural and in the second marcaine and fentanyl mixed. Stronger and longer analgesia was obtained in the series where fentanyl was added showing that local anaesthetics can be potentiated by opiates. There was no significant difference in the two series as far as the cardiovascular, respiratory and blood gas measurements were concerned, either in the mother or in the fetus.

Anesthesia, Epidural↗
PubMed1983

[Phosgene poisoning].

Phosgene, a combat gaz of the first world war is now very used in industry. Authors report a few observations about acute intoxications in the manufacture of this gaz in Toulouse. They insist about the risks of slow coming out lung oedema when safety instructions are not correctly followed. However better knowledge and observance of these instructions permitted a reduction of these intoxications in number and gravity.

Adult↗
PubMed1983

[Toxic pneumopathy following voluntary ingestion of 1 1/2 liters of gas-oil].

Authors recall an original observation about a twenty years old young girl who ingested one and half litre of gas-oil for suicide. A severe toxic lung disease appeared in the following days. Several weeks will be necessary for complete resorption, but no heavy breathing assistance will be needed. This observation confirmates the very rare cases described in publication.

Adult↗
PubMed1981

[Treatment of severe acute pancreatitis (30 cases). Respective role of surgery, intensive care and artificial nutrition (author's transl)].

The authors report on a retrospective study of 30 severe acute pancreatitis. The severity of the illness is documented by operative statement and evolution of the disease = 50 p. cent of mortality. A first group of 10 patients (1972-1975) was treated by primary intensive care and rapid ablative surgery with 10 deaths. A second group of 20 patients (1976-1980) was treated by primary intensive care, artificial nutrition and secondary surgical drainage. Mortality is significantly lower in the second group (5 deaths). It is concluded that all severe acute pancreatitis should be initially managed by intensive metabolic care and respiratory support if necessary. The only indication for primary surgery is a diagnostic doubt with peritonitis or bowell infarction. The authors emphasize the improvement of the prognosis of severe acute pancreatitis related to hemodynamic and respiratory measures and to a better nutritionnal support. Surgery should be secondary on a well prepared patient. Drainage or sequestrectomy support a lower mortality than ablative surgery.

Acute Disease↗
PubMed1981

[Massive blood transfusion in 50 seriously injured patients. Occurrence of pulmonary oedema (author's transl)].

This retrospective study shows correlations between the occurrence of pulmonary and massive blood transfusion in 50 seriously injured patients. They received massive transfusions on an average of 13 titers (minimum 51, maximum 30 l) including from 0 to 7,51 of macromolecular solutions (average 2,43 1). These seriously injured patients were divided into 4 groups: --20 thoracic injured patients with associated abdominal lesions, --15 thoracic injured patients without any abdominal lesions, --4 peripheral traumatism with abdominal lesions, --11 polytraumatic patients (considering only lesions of the limbs). There is a significant difference between seriously injured patients with associated abdominal lesions who were transfused and the other groups studied. Sixteen patients experienced pulmonary edema the diagnosis of which was reinforced on grounds of clinical, biological and radiological evidences. Significant difference (p:minor 0,05) were noted as regard the incidence of pulmonary edema when comparing the volume of fluids administrated to the different groups. New out of 16 patients died, mainly because of refractory hypoxia. When more than 25 liters of fluids are transfused, the prognosis is poor. Though pulmonary edema may be brought about by transfusion, other etiologic possibilities are to be investigated.

Abdominal Injuries↗
PubMed1979

Pharmacokinetics of fazadinium in patients with renal failure.

The serum concentrations of fazadinium and its metabolites were measured in 14 surgical patients with end-stage renal failure and in 11 patients free from kidney disease undergoing abdominal surgery. A two-compartment open model was used in the pharmacokinetic analysis of the data. The elimination half-life (T 1/2 beta) was prolonged by 60% in patients with renal failure (from 85 to 140 min) and corresponded to a 30% decrease of the plasma clearance. The plasma concentration of the metabolites never exceeded 7% of the unchanged fazadinium. These results suggest that the duration of action will be less prolonged for fazadinium than for other non-depolarizing neuromuscular blocking drugs in patients with renal failure. A supplementary biliary pathway appears to be a possible explanation for the rapid elimination of fazadinium, even in patients with renal failure.

Adult↗
PubMed1979

[Sedative measures during surgery on old patients. Result on ocular tension (author's transl)].

An attempt of sedative procedures associated with a locoregional anesthesia was performed on fifty old patients before cataract operation. The blood gases, the blood pressure and the heartrate were measured and the behaviour of the patient just before he awoke was examined to determinate the sedative value. A parallel study revealed a decrease of the intra ocular pressure of 2,5 mm d'Hg due to a slight decrease of the blood pressure and to the effect of the neurolep mixture: the Innovar. This method seems to be very satisfactory in Ophthalmology.

Aged↗
PubMed1978

[Modulator role of prostaglandins (Pg) in adrenergic neurotransmission in carotid sinus].

In Rabbit carotid sinus, the presence of sympathetic nerve endings capable of releasing noradrenaline has been demonstrated. The release of NA in response to sympathetic nerve stimulation was decreased by PgE2 and a precursor of Pg (arachidonic acid) but was strongly increased by an inhibitor of Pg biosynthesis (indomethacin). The experiments carried out demonstrated that freshly synthesized Pg acts in the same way as exogenous Pg and suggested that Pg could have a regulating effect on adrenergic neurotransmission in carotid sinus. The role of this regulating mechanism in the physiology of carotid sinus has been discussed.

Animals↗
PubMed1978

[Hemodynamic effects of dopamine, dobutamine and isoproterenol in chronic respiratory insufficiency].

A study of the effects of dopamine, dobutamine and of isoprenaline was carried out in 20 patients with chronic respiratory insufficiency, 16 of whom had pulmonary arterial hypertension (PAP: 22 mmHg). The following findings emerged: --absence of any significant effect of dobutamine on heart rate,--increase in systolic and mean PAP, after infusion of dobutamine,--increase in systolic and mean PAP, after infusion of dopamine,--decrease in BP after administration of infusion of dobutamine,--decrease in pulmonary arterial resistances under the influence of isoprenaline,--decrease in total systemic resistances after the administration of dobutamine,--increase in ventricular, systolic work after the infusion of dopamine.

Aged↗